Partial-volume Correction for High-resolution Positron Emission Tomography Using Cortical Surface Information PDF Download
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Author: Thomas Funck Publisher: ISBN: Category : Languages : en Pages :
Book Description
" Images from high resolution brain positron emission tomography (PET) scanners (CTI/Siemens HRRT) can measure differences in neuroreceptor concentrations in the gray matter that are related to cytoarchitectonic differences. However, the loss of resolution due to the PET imaging process results in partial-volume effects (PVE) that obscure the true radiotracer distribution. Although several partial-volume correction algorithms exist, these frequently require severely limiting assumptions. We developed a new iterative deconvolution algorithm for the partial-volume correction of PET images that aims to overcome the limitations of previous methods. The proposed method does so using two innovative techniques. One is the incorporation anatomic information from a cortical gray matter surface representation, extracted from magnetic resonance imaging (MRI). The second is the use of anatomically constrained smoothing to attenuate noise in the image. This method was validated using simulated and clinical data. The results show that our method consistently recovers accurate radiotracer concentrations on simulated data sets and produces similar, though slightly overestimated, results on the real clinical data when compared to the gold-standard partial-volume correction method. " --
Author: Thomas Funck Publisher: ISBN: Category : Languages : en Pages :
Book Description
" Images from high resolution brain positron emission tomography (PET) scanners (CTI/Siemens HRRT) can measure differences in neuroreceptor concentrations in the gray matter that are related to cytoarchitectonic differences. However, the loss of resolution due to the PET imaging process results in partial-volume effects (PVE) that obscure the true radiotracer distribution. Although several partial-volume correction algorithms exist, these frequently require severely limiting assumptions. We developed a new iterative deconvolution algorithm for the partial-volume correction of PET images that aims to overcome the limitations of previous methods. The proposed method does so using two innovative techniques. One is the incorporation anatomic information from a cortical gray matter surface representation, extracted from magnetic resonance imaging (MRI). The second is the use of anatomically constrained smoothing to attenuate noise in the image. This method was validated using simulated and clinical data. The results show that our method consistently recovers accurate radiotracer concentrations on simulated data sets and produces similar, though slightly overestimated, results on the real clinical data when compared to the gold-standard partial-volume correction method. " --
Author: Richard E. Carson Publisher: Elsevier ISBN: 0080540112 Category : Science Languages : en Pages : 535
Book Description
This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain. Authored by international authorities in PET Provides the latest up-to-date techniques and applications Covers all fundamental disciplines of PET in one volume A comprehensive resource for students, clinicians, and new PET researchers
Author: Elson L. So Publisher: Cambridge University Press ISBN: 110703423X Category : Medical Languages : en Pages : 259
Book Description
This book critically appraises the role and value of specific diagnostic and treatment techniques for drug-resistant, MRI-negative epilepsy. The authors present the evidence and share their expertise on the diagnostic options and surgical approaches that make epilepsy surgery possible and worthwhile in this complex and challenging condition.
Author: Andreas Maier Publisher: Springer ISBN: 3319965204 Category : Computers Languages : en Pages : 263
Book Description
This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.
Author: Thomas Wagner Publisher: Springer ISBN: 3319904124 Category : Medical Languages : en Pages : 112
Book Description
This pocket book provides clinicians with the necessary information to understand the role of FDG PET/CT in infection and inflammation. It will help both in making appropriate imaging requests with adequate clinical information and in interpreting the report. The coverage encompasses a wide range of topics, including the role of PET/CT in pyrexia of unknown origin, vasculitis, autoimmune diseases, prosthetic joint infections, osteomyelitis and diabetic foot, immunodeficiency disease, and vascular graft surgery. The book will be a very useful guide to a great test that can provide significant assistance in patient management. It is published within the Springer series Clinicians’ Guides to Radionuclide Hybrid Imaging, in which leading professionals succinctly explain the importance of nuclear medicine in the diagnosis and management of oncological and non-oncological conditions.
Author: Magdy M. Khalil Publisher: Springer ISBN: 3319400703 Category : Medical Languages : en Pages : 621
Book Description
This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.
Author: Andrea Bernasconi Publisher: Cambridge University Press ISBN: 1107108357 Category : Medical Languages : en Pages : 263
Book Description
Assembles world-class expertise on clinical and molecular imaging-derived biomarkers, presenting neuroimaging in epilepsy in a broad neuroscientific context.
Author: Christian P. Muller Publisher: Academic Press ISBN: 0080878172 Category : Science Languages : en Pages : 849
Book Description
Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft. The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour. This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise. The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders. The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community Of great value not only for researchers and experts, but also for students and clinicians as a background reference
Author: Thomas Funck
Author: Thomas Funck
Author: Shailendra Hemun Segobin
Author: Richard E. Carson
Author: Elson L. So
Author: Andreas Maier
Author: Thomas Wagner
Author: Magdy M. Khalil
Author: Andrea Bernasconi
Author: Christian P. Muller
Author: M. E. J. Young