Author: Ylva NilssonPublisher:
ISBN: 9789155434632
Category : Compounds, Unsaturated
Languages : en
Pages : 54
Book Description
Palladium-catalyzed Nucleophilic Addition to and Substitution of Unsaturated Hydrocarbons
Author: Ylva NilssonPublisher:
ISBN: 9789155434632
Category : Compounds, Unsaturated
Languages : en
Pages : 54
Book Description
Palladium Catalyzed Oxidation of Hydrocarbons
Author: P. HenryPublisher: Springer Science & Business Media
ISBN: 940099446X
Category : Science
Languages : en
Pages : 449
Book Description
The field of organometallic chemistry has emerged over the last twenty-five years or so to become one of the most important areas of chemistry, and there are no signs of abatement in the intense current interest in the subject, particularly in terms of its proven and potential application in catalytic reactions involving hydrocarbons. The development of the organometallic/ catalysis area has resulted in no small way from many contributions from researchers investigating palladium systems. Even to the well-initiated, there seems a bewildering and diverse variety of organic reactions that are promoted by palladium(II) salts and complexes. Such homogeneous reactions include oxidative and nonoxidative coupling of substrates such as olefins, dienes, acetylenes, and aromatics; and various isomerization, disproportionation, hydrogenation, dehydrogenation, car bonylation and decarbonylation reactions, as well as reactions involving formation of bonds between carbon and halogen, nitrogen, sulfur, and silicon. The books by Peter M. Maitlis - The Organic Chemistry of Palladium, Volumes I, II, Academic Press, 1971 - serve to classify and identify the wide variety of reactions, and access to the vast literature is available through these volumes and more recent reviews, including those of J. Tsuji [Accounts Chem. Res. , 6, 8 (1973); Adv. in Organometal. , 17, 141 (1979)], R. F. Heck [Adv. in Catat. , 26, 323 (1977)], and ones by Henry [Accounts Chem. Res. , 6, 16 (1973); Adv. in Organometal. , 13, 363 (1975)]. F. R. Hartley's book - The Chemistry of Platinum and Palladium, App!. Sci. Pub!.
New Palladium-Catalysed Intramolecular Coupling Reactions
Author: Francesco MarianiPublisher:
ISBN:
Category :
Languages : en
Pages : 200
Book Description
Although sygma-aryl and sygma-vinylpalladium(II) complexes are commonly used as electrophiles in C--C bond forming reactions, recent research has demonstrated that the same palladium intermediates can also react with carbon-heteroatom multiple bonds in a nucleophilic manner. Continuing with the interest of our group on the palladium-catalysed intramolecular coupling of aryl halides whit carbonyl compounds, we have expanded our previous findings to substrates containing other carbon-heteroatom multiple bonds. In this context, the first objective of the PhD Thesis has been the study of the dual nature of the sygma-arylpalladium(II) species in aldehyde containing compounds. Thus, after some preliminary studies on the ambiphilic character of the sygma-arylpalladium(II) intermediates involved in the palladium-catalysed intramolecular reactions of (2-iodoanilino)-aldehydes, we have described an efficient new methodology for the synthesis of dibenzo[b, e]azepin-11-ones based on the intramolecular acylation of aryl iodides with aldehydes. Continuing whit our interest in these nucleophilic addition processes, we have developed an efficient methodology for the preparation of a small library of tetrahydroisoquinolin-4-ols based on the palladium-catalysed intramolecular nucleophilic addition of a-(2-iodobenzylamino)- aldehydes. Finally, we have expanded the influence of the heteroatom (nitrogen, oxygen, and sulphur) on the course of the palladium-catalysed intramolecular reactions of aryl iodides and aldehydes having heteroatom--containing tethers. Through an extensive experimental-computational (DFT) study we have concluded that the nature of the heteroatom in the tether is not decisive for the outcome of these reactions. Continuing our research for methodologies that help us to increase the synthetic potential of organopalladium chemistry, we decide to investigate the feasibility of the palladium-catalysed intramolecular coupling of aryl halides and diazoderivatives as a methodology for the synthesis of nitrogen heterocycles. So, the second objective was the study of the Pd-catalysed intramolecular coupling of aryl halides with N-tosylhydrazones and sygma-diazoesters in nitrogen containing substrates. We have found that palladium can be used to catalyse the C(sp3)-H insertion of metal carbenoids derived from sygma-diazoesters to form pyrrolidines through intramolecular assembly of C(sp3)-C(sp3) bonds. This reaction is the first example of palladium-catalyzed C(sp3)-C(sp3) bond assembly starting from diazocarbonyl compounds. The coupling reaction can be catalyzed by both Pd(0) and Pd(II), is regioselective, and shows a broad functional group tolerance.
Palladium Catalyzed Nucleophilic Addition Reactions of Allylic Phosphonates and Their Application to the Preparation of Natural Products
Author: Bingli YanAddition Reactions with Unsaturated Hydrocarbons
Author: Ruimao HuaPublisher: John Wiley & Sons
ISBN: 352780482X
Category : Science
Languages : en
Pages : 452
Book Description
Addition Reactions with Unsaturated Hydrocarbons Provides comprehensive coverage of the atom-economic approach to functionalized molecules using unsaturated hydrocarbons as starting materials Unsaturated hydrocarbons have emerged as an important class of fundamental starting materials in organic synthesis. Synthetic methodologies incorporating unsaturated hydrocarbons continue to expand due to their numerous applications in the synthesis of a vast array of chemicals. Addition Reactions with Unsaturated Hydrocarbons presents an up-to-date overview of modern methods that utilize reactions of unsaturated hydrocarbons as building blocks of organic synthesis, covering the conceptual and practical knowledge required for designing atom-efficient reactions to synthesize functionalized molecules. This authoritative volume discusses homo-dimerization and cross-dimerization of alkynes and/or alkenes, synthesis of carbonyl compounds from the hydration of alkynes, cycloadditions of alkynes and alkenes for the synthesis of carbocycles and heterocycles, double functionalization of alkynes and alkenes by addition reactions of element-element bonds, and more. Summarizes the most recent developments in the reactions of unsaturated hydrocarbons Features more than 600 schemes describing typical reactions starting from unsaturated hydrocarbons Covers topics such as alkynylated reactions, addition and cycloaddition reactions of alkynes and alkenes, and carbonylation of alkynes and alkenes with carbon monoxide Includes examples of synthesis procedures of natural products involving alkyne transformation With comprehensive coverage of important reactions of unsaturated hydrocarbons, Addition Reactions with Unsaturated Hydrocarbons is a valuable resource for organic chemists, pharmaceutical chemists, and biochemists in both academia and industry as well as an excellent reference text for graduate students in relevant areas of chemistry.
Palladium-Catalyzed Nucleophilic Substitution of Alcohols
Author: Handbook of Organopalladium Chemistry for Organic Synthesis
Author: Ei-ichi NegishiPublisher: John Wiley & Sons
ISBN: 0471473812
Category : Science
Languages : en
Pages : 1657
Book Description
Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.
Handbook of Organopalladium Chemistry for Organic Synthesis
Author: Ei-ichi NegishiPublisher: Wiley-Interscience
ISBN: 0471473812
Category : Science
Languages : en
Pages : 3424
Book Description
Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.
Recent Advances in Copper- and Palladium-catalyzed Carbon-heteroatom and Carbon-carbon Bond-formation
Author: Ryan Alan AltmanPublisher:
ISBN:
Category :
Languages : en
Pages : 752
Book Description
Metal-catalyzed nucleophilic substitution reactions of aryl halides have become one of the most valuable and useful classes of reactions developed in the last 30 years. Foremost among these processes are the classes of palladium- and copper-catalyzed reactions, which employ heteroatom-based nucleophiles. Herein, newly designed catalyst systems are presented for the palladium- and/or copper-catalyzed nucleophilic substitution reactions of aryl halides with a variety of nucleophiles, including (benz)imidazoles, oxindoles, 2-, 3- and 4-hydroxypyridines, anilines, and aliphatic, benzylic, allylic and propargylic alcohols. In many cases, catalyst optimization and ligand structure are discussed and evaluated. Where applicable, the palladiumand copper-based catalyst systems are contrasted to demonstrate the complementary relationships between the employment of these two metals. Chapter One Chapter Two Chapter Three Chapter Four Chapter Five. Palladium- and Copper-catalyzed Reactions of Imidazoles and Benzimidazoles with Aryl Halides. Orthogonal Selectivity in Copper- and Palladium-catalyzed Reactions of Aryl Halides with Oxindoles. Copper-catalyzed Reactions of Hydroxypyridines and Related Compounds with Aryl Halides. Pyrrole-2-carboxylic Acid as a Ligand for the Copper-catalyzed Reactions of Primary Anilines with Aryl Halides. An Improved Copper-based Catalyst System for the Reactions of Aryl Halides with Aliphatic Alcohols.
Author: Fatima Khan