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Oral Delivery of Insulin

Oral Delivery of Insulin PDF Author: T.A. Sonia
Publisher: Elsevier
ISBN: 1908818689
Category : Medical
Languages : en
Pages : 361

Book Description
Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. - Presents an overview of Diabetes Mellitus - Includes a discussion of various strategies and techniques adopted for oral delivery of insulin - Presents an update of research in the field

Oral Delivery of Insulin

Oral Delivery of Insulin PDF Author: T.A. Sonia
Publisher: Elsevier
ISBN: 1908818689
Category : Medical
Languages : en
Pages : 361

Book Description
Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. - Presents an overview of Diabetes Mellitus - Includes a discussion of various strategies and techniques adopted for oral delivery of insulin - Presents an update of research in the field

Oral Delivery of Insulin

Oral Delivery of Insulin PDF Author: T.A. Sonia
Publisher: Woodhead Publishing
ISBN: 0443302731
Category : Medical
Languages : en
Pages : 0

Book Description
"Oral delivery of Insulin, 2nd Ed." is a complete reference on non-invasive insulin delivery systems, focusing on the prospect of oral delivery of peptides. The chapters in the revised edition present a comprehensive evaluation of the insulin therapy approaches with emphasis on insulin delivery strategies and current advances in engineered insulin delivery systems such as nano/microcarriers, and hydrogels. Including two new chapters, the contents were substantially updated. The first chapter provides an overview of diabetes mellitus, the second chapters covers the technological innovations in the treatment of diabetes, including pancreatic islet cell transplantation, stem cell therapy, ß-cells regeneration and gene therapy incretin therapy, statin therapy, metabolic surgery, and precision medicine approaches. Chapter three covers artificial intelligence and machine learning approaches to manage diabetes, including regulatory aspects. Chapter four explores a wide range of non-invasive and alternative routes of insulin administration. Chapter five covers the challenges and strategies in oral insulin delivery. Chapter six covers the experimental techniques used to develop oral insulin carriers. The next chapter is focused on the use of polymeric nano and microparticles for insulin delivery. Chapter eight focus on the use of lipids and inorganic nanoparticles in insulin delivery. The final chapter provide an overview of current clinical trials on insulin delivery and future perspectives in the area. "Oral delivery of Insulin, 2nd Ed." provides an updated and comprehensive overview of the current developments in non-invasive insulin delivery strategies. Pharmaceutical scientists will benefit from the broad coverage. Biomedical engineers can better understand combination approaches to develop new devices. Clinicians can benefit from this information to develop a clear understanding about the research carried out worldwide in the field of oral delivery of insulin including those in the clinical phase.• Covers AI/ML-based tools and devices in the diabetes management• Explores noninvasive routes of insulin delivery and techniques /approaches for maximizing the bioavailability• Discusses different delivery systems and approaches intended to increase the oral bioavailability of insulin

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems PDF Author: Emmanuel Opara
Publisher: CRC Press
ISBN: 0429584652
Category : Medical
Languages : en
Pages : 369

Book Description
This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.

Advanced Biopolymeric Systems for Drug Delivery

Advanced Biopolymeric Systems for Drug Delivery PDF Author: Amit Kumar Nayak
Publisher: Springer Nature
ISBN: 3030469239
Category : Technology & Engineering
Languages : en
Pages : 390

Book Description
This book discusses the recent innovations in the development of various advanced biopolymeric systems, including gels, in situ gels, hydrogels, interpenetrating polymer networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers, stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric micelles, dendrimers, liposomes and scaffolds. It also examines their applications in drug delivery.

Hypoglycemia in Diabetes

Hypoglycemia in Diabetes PDF Author: Philip Cryer
Publisher: American Diabetes Association
ISBN: 1580406491
Category : Medical
Languages : en
Pages : 194

Book Description
Intended for diabetes researchers and medical professionals who work closely with patients with diabetes, this newly updated and expanded edition provides new perspectives and direct insight into the causes and consequences of this serious medical condition from one of the foremost experts in the field. Using the latest scientific and medical developments and trends, readers will learn how to identify, prevent, and treat this challenging phenomenon within the parameters of the diabetes care regimen.

Nanoscience in Medicine Vol. 1

Nanoscience in Medicine Vol. 1 PDF Author: Hemant Kumar Daima
Publisher: Springer Nature
ISBN: 303029207X
Category : Medical
Languages : en
Pages : 503

Book Description
This book takes a systematic approach to address the gaps relating to nanomedicine and bring together fragmented knowledge on the advances on nanomaterials and their biomedical applicability. In particular, it demonstrates an exclusive compilation of state of the art research with a focus on fundamental concepts, current trends, limitations, and future directions of nanomedicine.

Drug Discovery and Evaluation: Methods in Clinical Pharmacology

Drug Discovery and Evaluation: Methods in Clinical Pharmacology PDF Author: H.Gerhard Vogel
Publisher: Springer Science & Business Media
ISBN: 3540898905
Category : Medical
Languages : en
Pages : 576

Book Description
Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".

Industrial Applications of Microemulsions

Industrial Applications of Microemulsions PDF Author: Conxita Solans
Publisher: CRC Press
ISBN: 9780824797959
Category : Science
Languages : en
Pages : 424

Book Description
"Fills a void in the literature by presenting the basic concepts of microemulsions, essential to understanding their industrial significance, and comprehensive descriptions of the most useful commerical applications. Discusses important issues related to enzymatic reactions and nanoparticle formation. Charts the enormous advances that have occurred in the field over the past decade."

Bioadhesive Drug Delivery Systems

Bioadhesive Drug Delivery Systems PDF Author: Edith Mathiowitz
Publisher: CRC Press
ISBN: 9781420001341
Category : Medical
Languages : en
Pages : 702

Book Description
This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs. Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport! Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles describes vaginal, nasal, buccal, ocular, and transdermal drug delivery reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts explores issues of product development, clinical testing, and production and more! Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; physical, surface, and colloid chemists; biologists; and upper-level undergraduate and graduate students in these disciplines.

CMBEBIH 2019

CMBEBIH 2019 PDF Author: Almir Badnjevic
Publisher: Springer
ISBN: 3030179710
Category : Technology & Engineering
Languages : en
Pages : 731

Book Description
This volume gathers the proceedings of the International Conference on Medical and Biological Engineering, which was held from 16 to 18 May 2019 in Banja Luka, Bosnia and Herzegovina. Focusing on the goal to ‘Share the Vision’, it highlights the latest findings, innovative solutions and emerging challenges in the field of Biomedical Engineering. The book covers a wide range of topics, including: biomedical signal processing, medical physics, biomedical imaging and radiation protection, biosensors and bioinstrumentation, bio-micro/nano technologies, biomaterials, biomechanics, robotics and minimally invasive surgery, and cardiovascular, respiratory and endocrine systems engineering. Further topics include bioinformatics and computational biology, clinical engineering and health technology assessment, health informatics, e-health and telemedicine, artificial intelligence and machine learning in healthcare, as well as pharmaceutical and genetic engineering. Given its scope, the book provides academic researchers, clinical researchers and professionals alike with a timely reference guide to measures for improving the quality of life and healthcare.