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Author: Li Jiang Publisher: ISBN: Category : Languages : en Pages : 113
Book Description
During my PhD studies I have worked on developing a number of optofluidics-based technologies with a primary emphasis on creating systems that maintain a relatively simple design and infrastructure while achieving a high level of functionality in their ability to perform complex tasks. Generally speaking my projects fall into two categories: programmable matter and global health. Programmable matter is the concept of creating a substance that can be reprogrammed and reconfigured to perform different tasks when the need arises. I developed an assembly technique that utilizes laser heating to create bubbles in a microfluidic environment, which are then used to connect microscale components. By granting the user control over placement of these "bubble latches," arbitrary structures can be formed and reconfigured in situ. My other projects have revolved around developing mobile microfluidic technologies, particularly for global health applications. This is driven by the fact that for all the significant advancements in lab-on-a-chip (LOC) technologies, consumer level uptake of such devices has been limited. This is primarily due to the need for a large number of external components (power source, computer, pump, etc.) to support the microfluidic chip, thus confining most technologies to lab settings. In my work I addressed some of the major overarching limitations of current LOC systems by exploiting the ubiquity of solar energy and smartphone technology to enable new microfluidic-based diagnostics. For example, by using an external light source such as sunlight, I demonstrated the ability to control flow in a microfluidic device without the need for powered pumps or valves. I have also invented a smartphoneassisted solar thermal method to perform polymerase chain reaction, a biochemical technique for amplifying nucleic acids. These novel technologies provide a means to perform complex diagnostics while dramatically reducing the reliance on external power and infrastructure. Such innovations could in the coming years help transform the healthcare landscape, particularly in the developing world.
Author: Li Jiang Publisher: ISBN: Category : Languages : en Pages : 113
Book Description
During my PhD studies I have worked on developing a number of optofluidics-based technologies with a primary emphasis on creating systems that maintain a relatively simple design and infrastructure while achieving a high level of functionality in their ability to perform complex tasks. Generally speaking my projects fall into two categories: programmable matter and global health. Programmable matter is the concept of creating a substance that can be reprogrammed and reconfigured to perform different tasks when the need arises. I developed an assembly technique that utilizes laser heating to create bubbles in a microfluidic environment, which are then used to connect microscale components. By granting the user control over placement of these "bubble latches," arbitrary structures can be formed and reconfigured in situ. My other projects have revolved around developing mobile microfluidic technologies, particularly for global health applications. This is driven by the fact that for all the significant advancements in lab-on-a-chip (LOC) technologies, consumer level uptake of such devices has been limited. This is primarily due to the need for a large number of external components (power source, computer, pump, etc.) to support the microfluidic chip, thus confining most technologies to lab settings. In my work I addressed some of the major overarching limitations of current LOC systems by exploiting the ubiquity of solar energy and smartphone technology to enable new microfluidic-based diagnostics. For example, by using an external light source such as sunlight, I demonstrated the ability to control flow in a microfluidic device without the need for powered pumps or valves. I have also invented a smartphoneassisted solar thermal method to perform polymerase chain reaction, a biochemical technique for amplifying nucleic acids. These novel technologies provide a means to perform complex diagnostics while dramatically reducing the reliance on external power and infrastructure. Such innovations could in the coming years help transform the healthcare landscape, particularly in the developing world.
Author: Tuhin Subhra Santra Publisher: MDPI ISBN: 3036506284 Category : Science Languages : en Pages : 254
Book Description
Cells are the most fundamental building block of all living organisms. The investigation of any type of disease mechanism and its progression still remains challenging due to cellular heterogeneity characteristics and physiological state of cells in a given population. The bulk measurement of millions of cells together can provide some general information on cells, but it cannot evolve the cellular heterogeneity and molecular dynamics in a certain cell population. Compared to this bulk or the average measurement of a large number of cells together, single-cell analysis can provide detailed information on each cell, which could assist in developing an understanding of the specific biological context of cells, such as tumor progression or issues around stem cells. Single-cell omics can provide valuable information about functional mutation and a copy number of variations of cells. Information from single-cell investigations can help to produce a better understanding of intracellular interactions and environmental responses of cellular organelles, which can be beneficial for therapeutics development and diagnostics purposes. This Special Issue is inviting articles related to single-cell analysis and its advantages, limitations, and future prospects regarding health benefits.
Author: Nam-Trung Nguyen Publisher: William Andrew ISBN: 1437735215 Category : Science Languages : en Pages : 369
Book Description
The ability to mix minute quantities of fluids is critical in a range of recent and emerging techniques in engineering, chemistry and life sciences, with applications as diverse as inkjet printing, pharmaceutical manufacturing, specialty and hazardous chemical manufacturing, DNA analysis and disease diagnosis. The multidisciplinary nature of this field – intersecting engineering, physics, chemistry, biology, microtechnology and biotechnology – means that the community of engineers and scientists now engaged in developing microfluidic devices has entered the field from a variety of different backgrounds. Micromixers is uniquely comprehensive, in that it deals not only with the problems that are directly related to fluidics as a discipline (aspects such as mass transport, molecular diffusion, electrokinetic phenomena, flow instabilities, etc.) but also with the practical issues of fabricating micomixers and building them into microsystems and lab-on-chip assemblies.With practical applications to the design of systems vital in modern communications, medicine and industry this book has already established itself as a key reference in an emerging and important field. The 2e includes coverage of a broader range of fabrication techniques, additional examples of fully realized devices for each type of micromixer and a substantially extended section on industrial applications, including recent and emerging applications. Introduces the design and applications of micromixers for a broad audience across chemical engineering, electronics and the life sciences, and applications as diverse as lab-on-a-chip, ink jet printing, pharmaceutical manufacturing and DNA analysis Helps engineers and scientists to unlock the potential of micromixers by explaining both the scientific (microfluidics) aspects and the engineering involved in building and using successful microscale systems and devices with micromixers The author's applied approach combines experience-based discussion of the challenges and pitfalls of using micromixers, with proposals for how to overcome them
Author: Guillaume Baffou Publisher: Cambridge University Press ISBN: 1108307868 Category : Science Languages : en Pages : 310
Book Description
Plasmonics is an important branch of optics concerned with the interaction of metals with light. Under appropriate illumination, metal nanoparticles can exhibit enhanced light absorption, becoming nanosources of heat that can be precisely controlled. This book provides an overview of the exciting new field of thermoplasmonics and a detailed discussion of its theoretical underpinning in nanophotonics. This topic has developed rapidly in the last decade, and is now a highly-active area of research due to countless applications in nanoengineering and nanomedicine. These important applications include photothermal cancer therapy, drug and gene delivery, nanochemistry and photothermal imaging. This timely and self-contained text is suited to all researchers and graduate students working in plasmonics, nano-optics and thermal-induced processes at the nanoscale.
Author: D. Pooja Publisher: Springer Nature ISBN: 981150671X Category : Technology & Engineering Languages : en Pages : 319
Book Description
This book discusses the sensitivity, selectivity, and response times of different sensor materials and their potential application in the design of portable sensor systems for monitoring water pollutants and remediation systems. Beginning with an overview on water pollutants and analytical methods for their detection, the book then moves on to describing the advances in sensor materials research, and the scope for their use in different types of sensors. The book lays emphasis on techniques such as colorimetric, fluorescence, electrochemical, and biological sensing of conventional and emerging pollutants. This book will serve as a handy guide for students, researchers, and professional engineers working in the field of sensor systems for monitoring water pollutants to address various challenges.
Author: Koji Sugioka Publisher: Springer ISBN: 3642105238 Category : Science Languages : en Pages : 353
Book Description
Miniaturization and high precision are rapidly becoming a requirement for many industrial processes and products. As a result, there is greater interest in the use of laser microfabrication technology to achieve these goals. This book composed of 16 chapters covers all the topics of laser precision processing from fundamental aspects to industrial applications to both inorganic and biological materials. It reviews the sate of the art of research and technological development in the area of laser processing.
Author: Andrew Adamatzky Publisher: Springer Science & Business Media ISBN: 9781852335403 Category : Computers Languages : en Pages : 588
Book Description
Collision-Based Computing presents a unique overview of computation with mobile self-localized patterns in non-linear media, including computation in optical media, mathematical models of massively parallel computers, and molecular systems. It covers such diverse subjects as conservative computation in billiard ball models and its cellular-automaton analogues, implementation of computing devices in lattice gases, Conway's Game of Life and discrete excitable media, theory of particle machines, computation with solitons, logic of ballistic computing, phenomenology of computation, and self-replicating universal computers. Collision-Based Computing will be of interest to researchers working on relevant topics in Computing Science, Mathematical Physics and Engineering. It will also be useful background reading for postgraduate courses such as Optical Computing, Nature-Inspired Computing, Artificial Intelligence, Smart Engineering Systems, Complex and Adaptive Systems, Parallel Computation, Applied Mathematics and Computational Physics.
Author: Publisher: ISBN: 9783038421948 Category : Single cell proteins Languages : en Pages : 0
Book Description
Annotation Cells play significant roles in our day to day life. However, the interactions of cells, the cellular responses of organelles to molecules, and their intracellular behaviour, are still not fully understood. To better understand the physiological interactions among molecules, organelles, and cells, the ensemble measurement of (on average, millions of) cells cannot provide detailed information. However, for example, research concerning the differentiation behaviors of stem cells or the metastatic processes of tumour initiation requires detailed information. Understanding genomic sequence information at a single cell level can promote an understanding of how individual parts of a cell are integrated in time and space to form dynamic cellular processes. The relationship between cellular heterogeneity and signaling pathway regulation may result in an understanding of disease states that can potentially drive therapeutic interventions. Thus single cell analysis (SCA) has been emerging as a powerful method of investigating exciting new insights into genomics, fluxomics, proteomics, and systems biology.
Author: Kewal K. Jain Publisher: Humana Press ISBN: 1493969668 Category : Technology & Engineering Languages : en Pages : 661
Book Description
Nanomedicine is defined as the application of nanobiotechnology in clinical medicine, which is currently being used to research the pathomechanism of disease, refine molecular diagnostics, and aid in the discovery, development, and delivery of drugs. In The Handbook of Nanomedicine, Third Edition, Prof. Kewal K. Jain updates, reorganizes, and replaces information in the comprehensive second edition in order to capture the most recent advances in this dynamic field. Important components of nanomedicine such as drug delivery via nanobiotechnology and nanopharmaceuticals as well as nanooncology, where the greatest number of advances are occurring, are covered extensively. As this text is aimed at nonmedical scientists, pharmaceutical personnel, as well as physicians, descriptions of the technology involved and other medical terminology are kept as clear and simple as possible. In depth and cutting-edge, The Handbook of Nanomedicine, Third Edition informs its readers of the ever-growing field of nanomedicine, destined to play a significant role in the future of healthcare.
Author: Li Jiang
Author: Li Jiang
Author: Tuhin Subhra Santra
Author: Nam-Trung Nguyen
Author: Guillaume Baffou
Author: D. Pooja
Author: Koji Sugioka
Author: Andrew Adamatzky
Author: 
Author: Kewal K. Jain
Author: Charles A. Belsterling