Pituitary Adenylate Cyclase-Activating Polypeptide PDF Download

Author: Hubert Vaudry
Publisher: Springer Science & Business Media
ISBN: 9781402073069
Category : Medical
Languages : en
Pages : 432

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Book Description
Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

Author: Thomas Stretch Dowse
Publisher:
ISBN:
Category : Neurasthenia
Languages : en
Pages : 84

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Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309072859
Category : Medical
Languages : en
Pages : 457

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Book Description
Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.

Author: Robert Vink
Publisher: University of Adelaide Press
ISBN: 0987073052
Category : Medical
Languages : en
Pages : 354

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Book Description
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Author: Leslie A. Pray
Publisher:
ISBN: 9780309297493
Category : Health & Fitness
Languages : en
Pages : 0

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Book Description
Caffeine in Food and Dietary Supplements is the summary of a workshop convened by the Institute of Medicine in August 2013 to review the available science on safe levels of caffeine consumption in foods, beverages, and dietary supplements and to identify data gaps. Scientists with expertise in food safety, nutrition, pharmacology, psychology, toxicology, and related disciplines; medical professionals with pediatric and adult patient experience in cardiology, neurology, and psychiatry; public health professionals; food industry representatives; regulatory experts; and consumer advocates discussed the safety of caffeine in food and dietary supplements, including, but not limited to, caffeinated beverage products, and identified data gaps. Caffeine, a central nervous stimulant, is arguably the most frequently ingested pharmacologically active substance in the world. Occurring naturally in more than 60 plants, including coffee beans, tea leaves, cola nuts and cocoa pods, caffeine has been part of innumerable cultures for centuries. But the caffeine-in-food landscape is changing. There are an array of new caffeine-containing energy products, from waffles to sunflower seeds, jelly beans to syrup, even bottled water, entering the marketplace. Years of scientific research have shown that moderate consumption by healthy adults of products containing naturally-occurring caffeine is not associated with adverse health effects. The changing caffeine landscape raises concerns about safety and whether any of these new products might be targeting populations not normally associated with caffeine consumption, namely children and adolescents, and whether caffeine poses a greater health risk to those populations than it does for healthy adults. This report delineates vulnerable populations who may be at risk from caffeine exposure; describes caffeine exposure and risk of cardiovascular and other health effects on vulnerable populations, including additive effects with other ingredients and effects related to pre-existing conditions; explores safe caffeine exposure levels for general and vulnerable populations; and identifies data gaps on caffeine stimulant effects.

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309316928
Category : Medical
Languages : en
Pages : 251

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Book Description
Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are serious, debilitating conditions that affect millions of people in the United States and around the world. ME/CFS can cause significant impairment and disability. Despite substantial efforts by researchers to better understand ME/CFS, there is no known cause or effective treatment. Diagnosing the disease remains a challenge, and patients often struggle with their illness for years before an identification is made. Some health care providers have been skeptical about the serious physiological - rather than psychological - nature of the illness. Once diagnosed, patients often complain of receiving hostility from their health care provider as well as being subjected to treatment strategies that exacerbate their symptoms. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome proposes new diagnostic clinical criteria for ME/CFS and a new term for the illness - systemic exertion intolerance disease(SEID). According to this report, the term myalgic encephalomyelitis does not accurately describe this illness, and the term chronic fatigue syndrome can result in trivialization and stigmatization for patients afflicted with this illness. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome stresses that SEID is a medical - not a psychiatric or psychological - illness. This report lists the major symptoms of SEID and recommends a diagnostic process.One of the report's most important conclusions is that a thorough history, physical examination, and targeted work-up are necessary and often sufficient for diagnosis. The new criteria will allow a large percentage of undiagnosed patients to receive an accurate diagnosis and appropriate care. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome will be a valuable resource to promote the prompt diagnosis of patients with this complex, multisystem, and often devastating disorder; enhance public understanding; and provide a firm foundation for future improvements in diagnosis and treatment.

Author: Y. Watanabe
Publisher: Springer Science & Business Media
ISBN: 9784431734642
Category : Medical
Languages : ja
Pages : 596

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Book Description
To provide a forum for discussion, the International Conference on Fatigue Science was organized, the first being held in 2002 in Sandhamn, Sweden, and the second in 2005 in Karuizawa, Japan. Subsequently it was decided that the papers presented at the two conferences should be collected. The result is an authoritative guide to recent progress in the molecular and neural mechanisms of fatigue and in the development of the ways to prevent and overcome fatigue and chronic fatigue.

Author: Thomas Stretch Dowse
Publisher:
ISBN:
Category : Influenza
Languages : en
Pages : 154

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Book Description

Author: Andy Abril
Publisher: Mayo Clinic Press
ISBN: 1893005496
Category : Health & Fitness
Languages : en
Pages : 274

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Book Description
Called the “invisible disease,” fibromyalgia is estimated to impact more than 10 million Americans. And yet, so much is still misunderstood about this chronic disorder. Mayo Clinic Guide to Fibromyalgia is an invaluable resource for understanding fibromyalgia and its debilitating symptoms. Those living with fibromyalgia know it is an invasive disorder, one that can cause overwhelming fatigue, joint stiffness, sleep problems, migraines, digestive problems, and troubles with memory and concentration, a symptom so common it is often referred to as “fibrofog.” While it's believed that humans have suffered from fibromyalgia for hundreds, even thousands, of years, a delay in medical research means many people living with fibromyalgia are still in the dark, confused by their symptoms and what causes the painful disorder. By drawing upon decades of advanced research in studying and treating fibromyalgia, Mayo Clinic Guide to Fibromyalgia combines anecdotes from real cases with expertise from Mayo Clinic’s rheumatology and chronic pain experts to provide an all-encompassing guide for understanding one of the most common chronic illnesses affecting Americans today. This book also offers reasonable, proven strategies—like worksheets to help readers craft a personalized daily plan—for managing common fibromyalgia symptoms, while serving as a comforting guide for those who may feel alone in their journey with fibromyalgia. This book breaks down what fibromyalgia is—and isn’t—in 4 separate sections: · Section 1 introduces fibromyalgia, the history and modern discoveries of fibromyalgia research, as well as common myths and misconceptions associated with the condition · Section 2 outlines the different treatment options available to those who suffer from fibromyalgia, including prescription medications, therapies, and forms of integrative medicine · Section 3 offers helpful tips for managing—and improving—chronic pain through diet, exercise, sleep, and stress management · Finally, Section 4 explains how to find guidance and support from your family, friends, and physicians to help you live a life unhindered by fibromyalgia If you’re struggling to advance past your painful fibromyalgia symptoms, get the book Publisher’s Weekly described as “the first [book] a newly diagnosed patient should consult.”

Author: Robert Hockey
Publisher: Cambridge University Press
ISBN: 1107244234
Category : Psychology
Languages : en
Pages : 289

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Book Description
Fatigue can have a major impact on an individual's performance and well-being, yet is poorly understood, even within the scientific community. There is no developed theory of its origins or functions, and different types of fatigue (mental, physical, sleepiness) are routinely confused. The widespread interpretation of fatigue as a negative consequence of work may be true only for externally imposed goals; meaningful or self-initiated work is rarely tiring and often invigorating. In the first book dedicated to the systematic treatment of fatigue for over sixty years, Robert Hockey examines its many aspects - social history, neuroscience, energetics, exercise physiology, sleep and clinical implications - and develops a new motivational control theory, in which fatigue is treated as an emotion having a fundamental adaptive role in the management of goals. He then uses this new perspective to explore the role of fatigue in relation to individual motivation, working life and well-being.