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Author: Publisher: BoD – Books on Demand ISBN: 1837693129 Category : Medical Languages : en Pages : 130
Book Description
As a member of the protein family known as neurotrophins, brain-derived neurotrophic factor (BDNF) plays a crucial role in supporting healthy brain function, which includes synaptic plasticity, cellular differentiation, learning, and the survival of nerve cells. Neuronal plasticity refers to the nervous system’s ability to adapt and respond to environmental conditions, involving various structural and functional mechanisms that can lead to changes in neural circuits, the formation of new synapses, and the generation of fresh neurons. BDNF has emerged as a significant regulator of neuronal plasticity. It is worth noting that the pathophysiological processes underlying central nervous system disorders and neuropsychiatric conditions such as depression, anxiety, autism, and schizophrenia, as well as neurodegenerative diseases like Parkinson’s and Alzheimer’s, are influenced by BDNF. Due to its robust neuroprotective properties and recently discovered anti-inflammatory and anti-apoptotic characteristics, BDNF has long been considered a potential candidate for preventing neurodegeneration. In the context of autism spectrum disorder, BDNF holds great promise as a central focus for therapeutic efforts. Its significance extends to the field of spinal cord injury, where it assumes a multifaceted role in the intricate pathophysiological processes at play. BDNF functions as a catalyst for the growth of axons, a crucial step in the restoration of the nervous system following damage. In the context of sepsis, research into the potential of BDNF’s anti-inflammatory properties to mitigate organ damage is quite noteworthy. Additionally, current findings suggest that combining exercise with vitamin D may offer a promising approach to increase BDNF levels and improve brain health. This book presents comprehensive information on BDNF and its role in promoting neuroprotection. The chapters offer insights into recent developments, molecular principles, and innovative therapeutic approaches for neurodegenerative disorders and brain health.
Author: Publisher: BoD – Books on Demand ISBN: 1837693129 Category : Medical Languages : en Pages : 130
Book Description
As a member of the protein family known as neurotrophins, brain-derived neurotrophic factor (BDNF) plays a crucial role in supporting healthy brain function, which includes synaptic plasticity, cellular differentiation, learning, and the survival of nerve cells. Neuronal plasticity refers to the nervous system’s ability to adapt and respond to environmental conditions, involving various structural and functional mechanisms that can lead to changes in neural circuits, the formation of new synapses, and the generation of fresh neurons. BDNF has emerged as a significant regulator of neuronal plasticity. It is worth noting that the pathophysiological processes underlying central nervous system disorders and neuropsychiatric conditions such as depression, anxiety, autism, and schizophrenia, as well as neurodegenerative diseases like Parkinson’s and Alzheimer’s, are influenced by BDNF. Due to its robust neuroprotective properties and recently discovered anti-inflammatory and anti-apoptotic characteristics, BDNF has long been considered a potential candidate for preventing neurodegeneration. In the context of autism spectrum disorder, BDNF holds great promise as a central focus for therapeutic efforts. Its significance extends to the field of spinal cord injury, where it assumes a multifaceted role in the intricate pathophysiological processes at play. BDNF functions as a catalyst for the growth of axons, a crucial step in the restoration of the nervous system following damage. In the context of sepsis, research into the potential of BDNF’s anti-inflammatory properties to mitigate organ damage is quite noteworthy. Additionally, current findings suggest that combining exercise with vitamin D may offer a promising approach to increase BDNF levels and improve brain health. This book presents comprehensive information on BDNF and its role in promoting neuroprotection. The chapters offer insights into recent developments, molecular principles, and innovative therapeutic approaches for neurodegenerative disorders and brain health.
Author: Publisher: Academic Press ISBN: 0128201908 Category : Medical Languages : en Pages : 404
Book Description
The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
Author: Colin R Martin Publisher: Academic Press ISBN: 0128158557 Category : Medical Languages : en Pages : 912
Book Description
Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1 consolidates different fields of dementia into a single book, covering a range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. With an impact on millions globally, and billions of research dollars being invested in dementia research, this book will stimulate research in the area and inform researchers. - Offers comprehensive coverage of a broad range of topics related to dementia - Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a "one-stop" source for everything you need to know about dementia
Author: Gary R. Lewin Publisher: Springer Science & Business Media ISBN: 3642451063 Category : Medical Languages : en Pages : 514
Book Description
This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.
Author: Bae Hwan Lee Publisher: Mdpi AG ISBN: 9783036519944 Category : Science Languages : en Pages : 408
Book Description
Dear Colleagues, The brain is vulnerable to injury. Following injury in the brain, apoptosis or necrosis may occur easily, leading to various functional disabilities. Neuronal death is associated with a number of neurological disorders including hypoxic ischemia, epileptic seizures, and neurodegenerative diseases. The brain subjected to injury is regarded to be responsible for the alterations in neurotransmission processes, resulting in functional changes. Oxidative stress produced by reactive oxygen species has been shown to be related to the death of neurons in traumatic injury, stroke, and neurodegenerative diseases. Therefore, scavenging or decreasing free radicals may be crucial for preventing neural tissues from harmful adversities in the brain. Neurotrophic factors, bioactive compounds, dietary nutrients, or cell engineering may ameliorate the pathological processes related to neuronal death or neurodegeneration and appear beneficial for improving neuroprotection. As a result of neuronal death or neuroprotection, the brain undergoes activity-dependent long-lasting changes in synaptic transmission, which is also known as functional plasticity. Neuroprotection implying the rescue from neuronal death is now becoming one of global health concerns. This Special Issue attempts to explore the recent advances in neuroprotection related to the brain. This Special Issue welcomes original research or review papers demonstrating the mechanisms of neuroprotection against brain injury using in vivo or in vitro models of animals as well as in clinical settings. The issues in a paper should be supported by sufficient data or evidence. Prof. Bae Hwan Lee Guest Editor
Author: Dilip Ghosh Publisher: Academic Press ISBN: 0128206101 Category : Technology & Engineering Languages : en Pages : 478
Book Description
Nutraceuticals in Brain Health and Beyond focuses on a variety of health disorders where intervention with nutritional supplements prove valuable, such as Alzheimer's, Parkinson's, autism, and attention-deficit disorder in children. In addition, Nutraceuticals in Brain Health and Beyond addresses "herb-nutra psychiatry" which is a field of research focused on developing a comprehensive, cohesive, and scientifically rigorous evidence base to shift conceptual thinking around the role of diet and nutrition in mental health.Intended for nutrition researchers, nutritionists, dieticians, regulatory bodies, health professionals, and students studying related fields, Nutraceuticals in Brain Health and Beyond will be a useful reference in understanding the links between nutrition and brain health. - Addresses nutritional psychiatry and cognitive health at all stages of the lifespan - Contains extensive coverage of vitamins, minerals, botanicals, and other nutrients - Offers novel insight into cognitive dysfunctions including depression and other neurodegenerative disorders - Explores the role of genomics and epigenetics, including discussion of the gut–brain axis
Author: Katherine A. Fitzgerald Publisher: Elsevier ISBN: 0080530206 Category : Medical Languages : en Pages : 526
Book Description
Completely revised and expanded, this second edition of The Cytokine FactsBook is the most up-to-date reference manual available for all current well-characterized interleukins, cytokines, and their receptors. An additional 52 cytokines are included, doubling the number of entries from the previous edition. The key properties of each cytokine are described and presented in a very accessible format with diagrams for each of the receptors. The Cytokine FactsBook includes free online access to the regularly updated Cytokine Webfacts. Cytokine Webfacts is a web-based comprehensive compendium of facts about cytokines and their receptors that includes a variety of data representations, such as text, signal pathway diagrams and 3D images. This exciting resource is integrated into other databases via hypertext links to provide a unique network, and contains a web-enabled version of RasMol for viewing structures.
Author: Publisher: Academic Press ISBN: 0123739616 Category : Medical Languages : en Pages : 1853
Book Description
As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research
Author: Jeffrey Noebels Publisher: OUP USA ISBN: 0199746540 Category : Medical Languages : en Pages : 1258
Book Description
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
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Author: Colin R Martin
Author: Cynthia Wetmore
Author: Gary R. Lewin
Author: Bae Hwan Lee
Author: Dilip Ghosh
Author: Katherine A. Fitzgerald
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Author: Jeffrey Noebels