OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 441: Hershberger Bioassay in Rats A Short-term Screening Assay for (Anti)Androgenic Properties PDF Download
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Author: OECD Publisher: OECD Publishing ISBN: 9264076336 Category : Languages : en Pages : 20
Book Description
The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the ...
Author: OECD Publisher: OECD Publishing ISBN: 9264076336 Category : Languages : en Pages : 20
Book Description
The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the ...
Author: OECD Publisher: OECD Publishing ISBN: 9264122648 Category : Languages : en Pages : 27
Book Description
This Test Guideline describes an in vitro screen for chemical effects on steroidogenesis, specifically the production of 17ß-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma cell line, used for the assay, expresses genes that ...
Author: OECD Publisher: OECD Publishing ISBN: 9264067418 Category : Languages : en Pages : 21
Book Description
The Uterotrophic Bioassay is an in vivo short-term screening test. It is based on the increase in uterine weight or uterotrophic response. The Uterotrophic Bioassay relies for its sensitivity on an animal test system in which the ...
Author: OECD Publisher: OECD Publishing ISBN: 9264185372 Category : Languages : en Pages : 25
Book Description
This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...
Author: OECD Publisher: OECD Publishing ISBN: 9264070729 Category : Languages : en Pages : 9
Book Description
This method provides information on health hazard likely to arise from short-term exposure to test substance. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been ...
Author: OECD Publisher: OECD Publishing ISBN: 9264071024 Category : Languages : en Pages : 15
Book Description
This Test Guideline has been designed to obtain the information necessary to confirm or to further characterise the potential neurotoxicity of chemicals in adult animals. This Test Guideline is designed for use with the rat. It specifically ...
Author: OECD Publisher: OECD Publishing ISBN: 926407094X Category : Languages : en Pages : 14
Book Description
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
Author: OECD Publisher: OECD Publishing ISBN: 9264076220 Category : Languages : en Pages : 38
Book Description
This Test Guideline describes an in vivo screening assay for certain endocrine active substances where sexually mature male and spawning female fish are held together and exposed to a chemical during a limited part of their life-cycle (21 days ...
Author: OECD Publisher: OECD Publishing ISBN: 9264070826 Category : Languages : en Pages : 14
Book Description
This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...
Author: OECD
Author: OECD
Author: OECD
Author: OECD
Author: OECD
Author: OECD
Author: OECD
Author: OECD
Author: OECD
Author: OECD
Author: OECD