OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage PDF Download

Author: OECD
Publisher: OECD Publishing
ISBN: 9264203869
Category :
Languages : en
Pages : 28

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Book Description
The Isolated Chicken Eye Test (ICE) Method is an in vitro test method that can be used to identify chemicals (substances or mixtures) as either 1) causing “serious eye damage” (category 1 of the Globally Harmonised System for the Classification and ...

Author: OECD
Publisher: OECD Publishing
ISBN: 9264542027
Category :
Languages : en
Pages : 35

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Book Description
This Test Guideline describes an in vitro procedure the identification on its own of chemicals (substances and mixtures) not requiring classification (No Cat), requiring classification for eye irritation (Cat 2) and requiring classification for serious eye damage (Cat 1) according to the UN GHS ocular hazard categories. It makes use of reconstructed human cornea-like epithelium (RhCE) which closely mimics the histological, morphological, biochemical and physiological properties of the human corneal epithelium.

Author: OECD
Publisher: OECD Publishing
ISBN: 926465609X
Category :
Languages : en
Pages : 30

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This Test Guideline proposes defined approaches (DA) combining data generated in vitro methods, with information sources such as physicochemical properties.

Author: OECD
Publisher: OECD Publishing
ISBN: 926418533X
Category :
Languages : en
Pages : 13

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This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...

Author: Organisation for Economic Co-operation and Development
Publisher: Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
ISBN: 9789264122215
Category : Chemical industry
Languages : en
Pages :

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Author: Laura Robinson
Publisher: John Wiley & Sons
ISBN: 1118882024
Category : Science
Languages : en
Pages : 402

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Book Description
Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author's training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.

Author:
Publisher:
ISBN:
Category : Hydraulic fluids
Languages : en
Pages : 380

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Author: Heather A.E. Benson
Publisher: CRC Press
ISBN: 0429529082
Category : Medical
Languages : en
Pages : 571

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Cosmetics are the most widely applied products to the skin and include creams, lotions, gels, and sprays. Their formulation, design, and manufacturing ranges from large cosmetic houses to small private companies. This book covers the current science in the formulations of cosmetics applied to the skin. It includes basic formulation, skin science, advanced formulation, and cosmetic product development, including both descriptive and mechanistic content with an emphasis on practical aspects.

Author: Monika Schäfer-Korting
Publisher: Springer Nature
ISBN: 3030700631
Category : Medical
Languages : en
Pages : 325

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Book Description
This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.

Author: Alexandra Maertens
Publisher: Royal Society of Chemistry
ISBN: 1839164409
Category : Science
Languages : en
Pages : 225

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Book Description
Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.