OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study PDF Download

Author: OECD
Publisher: OECD Publishing
ISBN: 9264067396
Category :
Languages : en
Pages : 26

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Book Description
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...

Author: OECD
Publisher: OECD Publishing
ISBN: 9264071024
Category :
Languages : en
Pages : 15

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Book Description
This Test Guideline has been designed to obtain the information necessary to confirm or to further characterise the potential neurotoxicity of chemicals in adult animals. This Test Guideline is designed for use with the rat. It specifically ...

Author: OECD
Publisher: OECD Publishing
ISBN: 9264070826
Category :
Languages : en
Pages : 14

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Book Description
This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...

Author: OECD
Publisher: OECD Publishing
ISBN: 9264070907
Category :
Languages : en
Pages : 8

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Book Description
The test substance is administered orally in a single dose to domestic hens. The animals are observed for 21 days, then the remainder of the hens are killed and histopathological examination is undertaken. The young adult domestic laying hen (Gallus ...

Author: OECD
Publisher: OECD Publishing
ISBN: 9264070923
Category :
Languages : en
Pages : 7

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Book Description
This Test Guideline is used in the assessment and evaluation of the toxic effects of organophosporus substances. Daily doses of the test substance are administered orally (preferably by gavage or administration of gelatin capsules) to domestic ...

Author: OECD
Publisher: OECD Publishing
ISBN: 9264070605
Category :
Languages : en
Pages : 20

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Book Description
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...

Author: OECD
Publisher: OECD Publishing
ISBN: 9264264388
Category :
Languages : en
Pages : 16

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Book Description
This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance.

Author: OECD
Publisher: OECD Publishing
ISBN: 9264071202
Category :
Languages : en
Pages : 18

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Book Description
The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...

Author: OECD
Publisher: OECD Publishing
ISBN: 926426440X
Category :
Languages : en
Pages : 19

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Book Description
This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. It has been updated with endocrine disruptor endpoints, in particular measure of anogenital distance and male nipple retention in pups and thyroid examination.

Author: OECD
Publisher: OECD Publishing
ISBN: 926407094X
Category :
Languages : en
Pages : 14

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Book Description
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...