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Author: Claudio Bucolo Publisher: Frontiers Media SA ISBN: 2889746445 Category : Science Languages : en Pages : 131
Book Description
The research on ocular pharmacology has increased significantly, over the past decade. More recently, the discovery and approval of eye disease modifying treatments is considered an unbelievable scientific breakthrough. Anti-VEGF molecules, cell therapy and gene therapy for age-related retinal degeneration, autologous corneal cells replacement, and Leber’s congenital amaurosis to name a few as some impressive examples. New drugs have been recently introduced for the treatment of glaucoma focusing on new pharmacological targets, such as Rho kinase inhibitors. For example, such novel treatments have been approved for optic neuromyelitis spectrum disorders. Regarding diseases of the front of the eye, advances have been reached with approval of recombinant Nerve Growth Factor (cenegermin) for treatment of neurotrophic keratitis. New discoveries and treatments recently introduced in ophthalmology should promote new efforts and encourage research in ocular pharmacology. It is noteworthy that several medical unmet needs remain in the field of ocular diseases, particularly for glaucoma, diabetic retinopathy (DR) and age-related macular degeneration (AMD). Early stages of DR or dry AMD need a cure and glaucoma deserves a new therapeutic approach in terms of retinal ganglion cells protection. Furthermore, current pharmacological treatments of glaucoma do not address one major issue underlying the pathology: neuroinflammation. When it comes to dry eye disorders, novel ophthalmic formulations and research findings focusing on immunomodulatory responses are welcomed to provide new insights on these conditions. Finally, one of the most challenging aspects in ocular pharmacology is related to ocular drug delivery. This Research Topic would like to address and discuss important medical unmet needs, and include a tangible contribution to handle sight threatening diseases that have a devastating impact not only for the patients but also for the healthcare system. This Research Topic aims to translate new basic science into clinically breakthrough therapies to help patients faced with debilitating ocular diseases. The Topic welcomes submissions of Original Research, Reviews, Clinical trials, and Case Reports articles that cover the following topics, but not limited to: • Diagnostic and prognostic biomarkers as potential pharmacological target of eye diseases (glaucoma, retinal diseases, ocular surface diseases). • Investigation on novel pharmacological targets for treatment of diabetic retinopathy, age related macular degeneration, glaucoma and dry eye. • New ocular drug delivery systems.
Author: Claudio Bucolo Publisher: Frontiers Media SA ISBN: 2889746445 Category : Science Languages : en Pages : 131
Book Description
The research on ocular pharmacology has increased significantly, over the past decade. More recently, the discovery and approval of eye disease modifying treatments is considered an unbelievable scientific breakthrough. Anti-VEGF molecules, cell therapy and gene therapy for age-related retinal degeneration, autologous corneal cells replacement, and Leber’s congenital amaurosis to name a few as some impressive examples. New drugs have been recently introduced for the treatment of glaucoma focusing on new pharmacological targets, such as Rho kinase inhibitors. For example, such novel treatments have been approved for optic neuromyelitis spectrum disorders. Regarding diseases of the front of the eye, advances have been reached with approval of recombinant Nerve Growth Factor (cenegermin) for treatment of neurotrophic keratitis. New discoveries and treatments recently introduced in ophthalmology should promote new efforts and encourage research in ocular pharmacology. It is noteworthy that several medical unmet needs remain in the field of ocular diseases, particularly for glaucoma, diabetic retinopathy (DR) and age-related macular degeneration (AMD). Early stages of DR or dry AMD need a cure and glaucoma deserves a new therapeutic approach in terms of retinal ganglion cells protection. Furthermore, current pharmacological treatments of glaucoma do not address one major issue underlying the pathology: neuroinflammation. When it comes to dry eye disorders, novel ophthalmic formulations and research findings focusing on immunomodulatory responses are welcomed to provide new insights on these conditions. Finally, one of the most challenging aspects in ocular pharmacology is related to ocular drug delivery. This Research Topic would like to address and discuss important medical unmet needs, and include a tangible contribution to handle sight threatening diseases that have a devastating impact not only for the patients but also for the healthcare system. This Research Topic aims to translate new basic science into clinically breakthrough therapies to help patients faced with debilitating ocular diseases. The Topic welcomes submissions of Original Research, Reviews, Clinical trials, and Case Reports articles that cover the following topics, but not limited to: • Diagnostic and prognostic biomarkers as potential pharmacological target of eye diseases (glaucoma, retinal diseases, ocular surface diseases). • Investigation on novel pharmacological targets for treatment of diabetic retinopathy, age related macular degeneration, glaucoma and dry eye. • New ocular drug delivery systems.
Author: Thomas Yorio Publisher: Academic Press ISBN: 0080556779 Category : Science Languages : en Pages : 537
Book Description
Ocular Therapeutics: Eye on New Discovery focuses on emerging areas in ocular research, from new approaches to dry eye to gene therapy in the management of retinal diseases. This comprehensive book features more than 25 chapters of information that will be vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics. It is the intent of this book to provide not only information on current approaches to treatment, but also in giving the reader a greater understanding as to what may become available for treating a number of important eye diseases. Each chapter features some new aspect of treatment that holds great promise for the future. The approach has been to concentrate on those areas of ocular diseases that are more prevalent. It also features new insight for drug delivery and for managing devasting diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States. This book will serve as an important resource as it contains a number of relevant references highlighted for their importance to the field. New investigators will be able to obtain an historical perspective for each of the topics and to develop an understanding of the new research directions that are underway. Ocular Therapeutics: Eye on New Discovery is more than a reference book, as it also provides an important glimpse into the near future.* Contains information that is vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics.* Provides not only information on current approaches to treatment, but also gives the reader a greater understanding as to what may become available for treating a number of important eye diseases.* Historical perspective for each of the topics as well as an important glimpse into the near future to develop an understanding of the new research directions underway.* New insight for drug delivery and for managing devastating diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States
Author: Jimmy D. Bartlett Publisher: Elsevier Health Sciences ISBN: 0750675764 Category : Medical Languages : en Pages : 816
Book Description
Written by experts in the field, this comprehensive resource offers valuable information on the practical uses of drugs in primary eye care. Discussions of the pharmacology of ocular drugs such as anti-infective agents, anti-glaucoma drugs, and anti-allergy drugs lead to more in-depth information on ocular drugs used to treat a variety of disorders, including diseases of the eyelids, corneal diseases, ocular infections, and glaucoma. The book also covers ocular toxicology, focusing on drug interactions, ocular effects of systemic drugs, and life-threatening systemic emergencies. A logical organization makes it easy to find essential information. Complete coverage of the basic fundamentals of pharmacology such as ocular drug delivery and ocular drug formulations. Comprehensive reviews of the pharmacology of specific classes of agents such as the cycloplegics, antiglaucoma drugs, anti-inflammatory drugs, ocular irrigating solutions, and contact lens care products. In-depth information on ocular drugs used in clinical practice, including chapters on drugs used to treat eyelid disorders, lacrimal diseases, conjunctiva diseases, corneal diseases, allergies, uveitis, postoperative cataract, retinal diseases, and glaucoma. Coverage of ocular toxicology, including drug interactions, ocular effects of systemic drugs, and life-threatening systemic emergencies. Completely revised and updated content that reflects the latest advances in pharmacology. Updated information on post-operative drugs, including LASIK follow up medications. Expanded coverage in the chapters on Anti-infective Drugs, Anti-allergy Drugs and Decongestants, and Lubricants and Other Preparations of Ocular Surface Disease that includes the latest advancements in antibiotics and medications used to treat allergies and dry eye. A dosage quick reference guide on the inside front cover for quick and easy access. Information on the use of herbal medications.
Author: Thom J. Zimmerman Publisher: Lippincott Williams & Wilkins ISBN: Category : Medical Languages : en Pages : 936
Book Description
This reference, highlighting the latest breakthroughs in ocular pharmacology, presents information on disease, pathogenesis and pharmacological treatment of a wide range of ocular conditions.
Author: Sunny Ohia Publisher: Academic Press ISBN: 0128192925 Category : Medical Languages : en Pages : 673
Book Description
Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics provides a review of the basic anatomy, physiology, biochemistry and pathology of the eye with a focus drug therapy, drug delivery and use of therapeutic medical miniature devices. An understanding of the pharmacological actions of drugs acting on the eye requires the student and health care practitioner to learn additional principles in basic and clinical sciences that are unique to this organ. As a sensory organ, the eye is relatively inaccessible to the systemic circulation due to the blood-vitreous, blood-aqueous and blood-retinal barriers. Consequently, the administration of drugs for therapeutic effects in the eye necessitates an understanding of physico-chemical properties of the molecules and pharmacokinetic principles involved in the access to its site of action via topical, intracameral and intravitreal administration. This book includes information on the general principles of pharmacokinetics and pharmacodynamics of drugs as it pertains to the eye and in combating ocular disorders and diseases. Using a disease-themed approach, the book discusses basic and clinical pharmacological principles involved in the therapy of these diseases including the ocular side effect of systemically-administered drugs, drugs used in ophthalmic surgery and miscellaneous agents, the therapeutic utility of biologics, drug conjugates, combination products, gene and cellular therapy are also covered. Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics is useful as a primary and secondary source of reference for up-to-date information about the pharmacological mechanisms of action, pharmacokinetics, side effects, drug-drug interactions and therapeutic indications of drugs for pharmacologists, pharmaceutical scientists, students in the health care disciplines (nursing, pharmacy, optometry, medical), and practitioners in optometry and ophthalmology. - Explains the mechanisms of action, side-effects and therapeutic uses of drugs, biologics, miniature devices, gene and cellular therapies for the eye - Provides a comprehensive review of the anatomy, physiology, biochemistry, pharmacology, microbiology, genetics and pathology of parts of the eye involved in drug therapy to combat eye disorders and diseases - Explores the pharmacological and clinical basis of drugs, drug conjugates, combination products used in the treatment of anterior and posterior segment diseases
Author: Ashim K. Mitra Publisher: CRC Press ISBN: 9780367446765 Category : Languages : en Pages : 847
Book Description
The second edition of this text assembles significant ophthalmic advances and encompasses breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309292492 Category : Medical Languages : en Pages : 107
Book Description
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Author: Claudio Bucolo
Author: Claudio Bucolo
Author: Thomas Yorio
Author: Jimmy D. Bartlett
Author: S K Gupta
Author: Thom J. Zimmerman
Author: 
Author: 
Author: Sunny Ohia
Author: Ashim K. Mitra
Author: Institute of Medicine