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Author: Benedicte Fontaine-Bisson Publisher: ISBN: 9780494398890 Category : Languages : en Pages : 294
Book Description
Chronic inflammation is a common feature of obesity, type 2 diabetes and cardiovascular disease. Nuclear factor kappa B (NF-kappaB) is a transcription factor that plays a central role in inflammation by regulating the expression of a number of important genes, such as the major pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha. Both NF-kappaB and TNF-alpha have been implicated in the pathogenesis of insulin resistance and the development of a pro-atherogenic lipid profile. Their production can be modulated by dietary polyunsaturated fatty acids (PUFAs), from both the n-3 and n-6 series, as well as by genetic variations that alter transcriptional activity. The objective of this thesis was to determine whether common variations in major genes regulating inflammation (NF-kappaB and TNF-alpha) modify the association between dietary PUFAs intake and biomarkers of cardiovascular disease in two different populations. In summary, the NF-kappaB -49Ins/Del ATTG and TNF-alpha -238G>A and -308 G>A polymorphisms modify the association between dietary PUFAs intake and plasma HDL-cholesterol in two different populations. Taken together, these findings suggest that inflammation may mediate the effect of dietary PUFAs on the reverse cholesterol transport and impact the risk of cardiovascular disease. The first population involved overweight or obese men and women (n=109) aged 42--75 years with type 2 diabetes. The second population involved mostly lean and healthy men and women (n=595) aged 20--29 years. Subjects were genotyped for the NF-kappaB -49Ins/Del ATTG and for the TNF-alpha -238G>A and -308G>A polymorphisms. Dietary intake was assessed using either a 3-day food record or a food frequency questionnaire. Among individuals with type 2 diabetes, the association between dietary PUFAs intake and plasma HDL-cholesterol concentrations was modified by variations in both the NF-kappaB and TNF-alpha genes. The association between PUFAs intake and HDL-cholesterol was either positive, inverse or null, depending on the particular NF-kappaB and TNF-alpha genotype. In the population of young adults, genetic variations in both the NF-kappaB and TNF-alpha genes also modified the association between dietary PUFAs intake and plasma HDL-cholesterol. NF-kappaB and TNF-alpha genotypes did not modify the association between other dietary fatty acids and other plasma lipids in either population.
Author: Benedicte Fontaine-Bisson Publisher: ISBN: 9780494398890 Category : Languages : en Pages : 294
Book Description
Chronic inflammation is a common feature of obesity, type 2 diabetes and cardiovascular disease. Nuclear factor kappa B (NF-kappaB) is a transcription factor that plays a central role in inflammation by regulating the expression of a number of important genes, such as the major pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha. Both NF-kappaB and TNF-alpha have been implicated in the pathogenesis of insulin resistance and the development of a pro-atherogenic lipid profile. Their production can be modulated by dietary polyunsaturated fatty acids (PUFAs), from both the n-3 and n-6 series, as well as by genetic variations that alter transcriptional activity. The objective of this thesis was to determine whether common variations in major genes regulating inflammation (NF-kappaB and TNF-alpha) modify the association between dietary PUFAs intake and biomarkers of cardiovascular disease in two different populations. In summary, the NF-kappaB -49Ins/Del ATTG and TNF-alpha -238G>A and -308 G>A polymorphisms modify the association between dietary PUFAs intake and plasma HDL-cholesterol in two different populations. Taken together, these findings suggest that inflammation may mediate the effect of dietary PUFAs on the reverse cholesterol transport and impact the risk of cardiovascular disease. The first population involved overweight or obese men and women (n=109) aged 42--75 years with type 2 diabetes. The second population involved mostly lean and healthy men and women (n=595) aged 20--29 years. Subjects were genotyped for the NF-kappaB -49Ins/Del ATTG and for the TNF-alpha -238G>A and -308G>A polymorphisms. Dietary intake was assessed using either a 3-day food record or a food frequency questionnaire. Among individuals with type 2 diabetes, the association between dietary PUFAs intake and plasma HDL-cholesterol concentrations was modified by variations in both the NF-kappaB and TNF-alpha genes. The association between PUFAs intake and HDL-cholesterol was either positive, inverse or null, depending on the particular NF-kappaB and TNF-alpha genotype. In the population of young adults, genetic variations in both the NF-kappaB and TNF-alpha genes also modified the association between dietary PUFAs intake and plasma HDL-cholesterol. NF-kappaB and TNF-alpha genotypes did not modify the association between other dietary fatty acids and other plasma lipids in either population.
Author: Yoshinori Mine Publisher: John Wiley & Sons ISBN: 0813807174 Category : Technology & Engineering Languages : en Pages : 413
Book Description
Part of the Functional Food Science and Technology book series (Series Editor: Fereidoon Shahidi), this book compiles the current science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals (food factors) and their impact on gene interaction and health. Authored by a stellar international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date.
Author: Martin Kussmann Publisher: John Wiley & Sons ISBN: 1119098831 Category : Technology & Engineering Languages : en Pages : 350
Book Description
Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date. Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe-derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene-nutrient network analysis, and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology-based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.
Author: Ioannis Zabetakis Publisher: Academic Press ISBN: 0128137924 Category : Technology & Engineering Languages : en Pages : 348
Book Description
The Impact of Nutrition and Statins on Cardiovascular Diseases presents a summary of the background information and published research on the role of food in inhibiting the development of cardiovascular diseases. Written from a food science, food chemistry, and food biochemistry perspective, the book provides insights on the origin of cardiovascular diseases, an analysis of statin therapy, their side effects, and the role of dietary intervention as an alternative solution to preventing cardiovascular diseases. It focuses on the efficacy of nutrition and statins to address inflammation and inhibit the onset of disease, while also providing nutrition information and suggested dietary interventions. Includes a bioscience approach that focuses on inflammation and revisits the lipid hypothesis Presents the view that nutritional interventions have considerable value, not only for reducing cardiovascular risk for CVDs patients, but also acting as the best precaution for otherwise healthy people Advocates that nutritional habits that are formed at a young age are the best way to tackle the global epidemic that is CVDs
Author: National Academies of Sciences, Engineering, and Medicine Publisher: National Academies Press ISBN: 0309477646 Category : Medical Languages : en Pages : 155
Book Description
On December 5, 2017, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop titled Nutrigenomics and the Future of Nutrition in Washington, DC, to review current knowledge in the field of nutrigenomics as it relates to nutrition. Workshop participants explored the influence of genetic and epigenetic expression on nutritional status and the potential impact of personalized nutrition on health maintenance and chronic disease prevention. This publication summarizes the presentations and discussions from the workshop.
Author: Lynnette R. Ferguson Publisher: CRC Press ISBN: 1439876819 Category : Medical Languages : en Pages : 439
Book Description
While functional foods have become a reasonably well-established concept, personalized nutrition is still treated with skepticism by many. The recognition that people would have different nutrient requirements, or perceive foods in different ways, raises several concerns-some real, some not so real. Nutrigenomics and Nutrigenetics in Functional Foo
Author: Gün?en, U?ur Publisher: IGI Global ISBN: 1799835960 Category : Medical Languages : en Pages : 214
Book Description
Food selection plays an important role in ensuring pro- and anti-inflammatory balance. Certain foods are responsible for increasing inflammation while others have anti-inflammation properties. Western diets especially, rich in red meat, simple carbohydrates, and refined grains, increase the levels of pro-inflammatory markers, C-reactive protein (CRP), and interleukin-6 (IL-6). Additionally, short- and long-chain fatty acids, various micronutrients including zinc, selenium, iron, vitamin A, probiotics, and prebiotic foods affect inflammation. As inflammation can be linked to a variety of diseases, more studies are needed about nutrition and its ability to prevent inflammation. Role of Nutrition in Providing Pro-/Anti-Inflammatory Balance: Emerging Research and Opportunities is an essential publication that examines balancing inflammation through nutrition and nutritional strategies. Firstly, information about the formation process of inflammation, biomarkers used for diagnosis, diseases affected by inflammation, and their incidence in society are discussed. Subsequently, balancing inflammation in individuals through macro- and micro-nutrient consumption, nutritional supplements (probiotics and prebiotics), bioactive proteins and peptides, and dietary forms is examined. Featuring research covering a broad range of topics including food supplements, diet types, and bioactive proteins, this book is ideally designed for nutritionists, dieticians, clinicians, doctors, nurses, healthcare providers, researchers, academicians, and students.
Author: Devarajan Thangadurai Publisher: CRC Press ISBN: 1000580741 Category : Health & Fitness Languages : en Pages : 308
Book Description
Implementation of robust omics technologies enables integrative and holistic interrogation related to nutrition by labeling biomarkers to empirically assess the dietary intake. Nutriomics: Well-being through Nutrition aims to enhance scientific evidence based on omics technologies and effectiveness of nutrition guidelines to promote well-being. It provides deep understanding towards nutrients and genotype effects on disease and health status. It also unveils the nutrient–health relation at the population and individual scale. This book helps to design the precise nutritional recommendations for prevention or treatment of nutrition-related syndromes. Nutriomics: Well-being through Nutrition focuses on: The impact of molecular approaches to revolutionize nutrition research for human well-being Various biomarkers for bioactive ingredient analysis in nutritional intervention research Potential of transcriptomic, genomic, proteomic, metabolomic, and epigenomic tools for nutrition care practices Recent updates on applications of omics technologies towards personalized nutrition Providing comprehensive reviews about omics technologies in nutritional science, Nutriomics: Well-being through Nutrition serves as an advanced source of reference for food developers, nutritionists, and dietary researchers to investigate and evaluate nutriomics tools for development of customized nutrition and food safety. It is also a useful source for clinicians and food industry officials who require intense knowledge about emerging dietary-related tools to revolutionize the nutrition industry. This is a volume in the Food Analysis and Properties series, a series designed to provide state-of-art coverage on topics to the understanding of physical, chemical, and functional properties of foods.
Author: Frans Kok Publisher: CRC Press ISBN: 1420009176 Category : Medical Languages : en Pages : 306
Book Description
From one person to the next, optimal health is governed by a huge array of minor genetic differences. When modulated by a variety of food bioiactives, these differences result in changes in gene expression and subsequent phenotypic expression. Combining biomedical and social science with contributions from leaders in both fields, Personalized Nutri
Author: Benedicte Fontaine-Bisson
Author: Benedicte Fontaine-Bisson
Author: Yoshinori Mine
Author: Martin Kussmann
Author: Ioannis Zabetakis
Author: National Academies of Sciences, Engineering, and Medicine
Author: Lynnette R. Ferguson
Author: Gün?en, U?ur
Author: Devarajan Thangadurai
Author: Frans Kok
Author: Jeffrey Bland