Novel Treatment Strategies for Glioblastoma PDF Download

Author: Stanley Stylli
Publisher: Mdpi AG
ISBN: 9783036525990
Category :
Languages : en
Pages : 282

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Book Description
This book is a compilation of articles that brings together current knowledge from an international team of contributors who are dedicated investigators exploring novel strategies for the treatment of glioblastoma. These articles describe some of the latest concepts that will provide students, researchers and clinicians with an overview of the therapeutic approaches being developed in the field of neuro-oncology to combat this deadly disease.

Author: Swapan K. Ray
Publisher: Springer Science & Business Media
ISBN: 1441904107
Category : Medical
Languages : en
Pages : 427

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Book Description
Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.

Author:
Publisher: Academic Press
ISBN: 0128211156
Category : Medical
Languages : en
Pages : 374

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Book Description
Novel Therapeutic Advances in Glioblastoma, Volume 151 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Blood-brain barrier and pathophysiology of brain tumors, Promising strategies of glioblastoma treatment: personalized genotoxic therapy and stem cell transplantation, Extracellular matrix and biocompatible materials in glioblastoma treatment, Expression of Twist associated to microcirculation patterns of human glioma correlated with progression and survival of the patient, Advanced Multimodal Imaging in Differentiating Glioma Recurrence from Post-radiotherapy Changes, Advanced Multimodal Imaging in Differentiating Glioma Recurrence from Post-radiotherapy Changes, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Neurobiology series Updated release includes the latest information on glioblastomas

Author: Ana Lucia Abujamra
Publisher: IntechOpen
ISBN: 9789533075884
Category : Medical
Languages : en
Pages : 434

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Book Description
Brain Tumors: Current and Emerging Therapeutic Strategies focuses on tumor models, the molecular mechanisms involved in the pathogenesis of this disease, and on the new diagnostic and treatment strategies utilized to stage and treat this malignancy. A special section on immunotherapy and gene therapy provides the most up-to-date information on the pre-clinical and clinical advances of this therapeutic venue. Each chapter in Brain Tumors: Current and Emerging Therapeutic Strategies is authored by international experts with extensive experience in the areas covered.

Author: Ana Lucia Abujamra
Publisher: IntechOpen
ISBN: 9789533075884
Category : Medical
Languages : en
Pages : 434

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Book Description
Brain Tumors: Current and Emerging Therapeutic Strategies focuses on tumor models, the molecular mechanisms involved in the pathogenesis of this disease, and on the new diagnostic and treatment strategies utilized to stage and treat this malignancy. A special section on immunotherapy and gene therapy provides the most up-to-date information on the pre-clinical and clinical advances of this therapeutic venue. Each chapter in Brain Tumors: Current and Emerging Therapeutic Strategies is authored by international experts with extensive experience in the areas covered.

Author: Michael E. Sughrue
Publisher: Academic Press
ISBN: 0128136340
Category : Medical
Languages : en
Pages : 256

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Book Description
New Techniques for Management of 'Inoperable' Gliomas radically challenges the assumption that certain gliomas cannot be removed with modern techniques, contesting stereotypical thinking and establishing new paradigms in the field. Gliomas are primary brain tumors which are often fatal. Recent data has demonstrated that despite the fact that surgery cannot cure gliomas, patient survival is substantially improved by removing as much of the tumor as possible. This fact has raised the imperative that neurologists try to improve techniques to bring surgical resection to as many patients as possible. This book brings new insights and technologies to the forefront, giving hope to patients. Provides the first comprehensive book to discuss techniques for removing gliomas that are traditionally deemed ‘inoperable’ Presents a great reference tool that challenges stereotypical thinking by offering techniques by innovative surgeons Includes chapters that are organized by different glioma types and surgery/techniques

Author: Terry Lichtor
Publisher: BoD – Books on Demand
ISBN: 9535110586
Category : Medical
Languages : en
Pages : 656

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Book Description
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients. In this book a review of the options available for the clinical management of patients with these tumors are outlined. In addition advances in radiology both for pre-operative diagnostic purposes along with surgical planning are described. Furthermore a review of newer developments in chemotherapy along with the evolving field of photodynamic therapy both for intra-operative management and subsequent therapy is provided. A discussion of certain surgical management issues along with tumor induced epilepsy is included. Finally a discussion of the management of certain unique problems including brain metastases, brainstem glioma, central nervous system lymphoma along with issues involving patients with a brain tumor and pregnancy is provided.

Author: M.F. Chernov
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318060631
Category : Medical
Languages : en
Pages : 236

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Book Description
At present most intracranial gliomas are considered incurable with current treatment strategies, and the search for new modalities that may effectively control tumor growth continues. The chapters in this volume describe basic principles and therapeutic possibilities of several innovative techniques, including photodynamic therapy, laser-induced interstitial thermotherapy, stereotactic cryodestruction, high-intensity focused ultrasound ablation, boron neutron capture therapy, proton and carbon ion irradiation, targeted therapy, immunotherapy, gene therapy, local chemotherapy, and alternating electric fields therapy. Potential applications of extracellular vesicles and nanotechnology for management of gliomas are highlighted as well. Many of these methods have already demonstrated antitumor efficacy in clinical testing, whereas others are still under development. The materials presented in this book are mainly directed at clinicians treating patients with brain tumors, as well as clinical and basic researchers working in the field of neuro-oncology.

Author: Alexandra JD Sufit
Publisher:
ISBN:
Category :
Languages : en
Pages : 163

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Book Description
Glioblastoma multiforme is a dismal disease with a prognosis of 12-14 months following diagnosis. Patients diagnosed with this disease have a 5% 5-year survival rate. Unfortunately, these statistics have not changed in 30 years despite ongoing research within the field. The current standard of care therapy of gross total resection (if eligible) followed by radiation and chemotherapy, temozolomide, is limited and only offer a few months of prolonged life. Genomic analysis of tumors has identified many mutations, amplifications, and genetic anomalies within the cancer DNA repertoire. Improving our understanding of the molecular alterations in this disease through these identifications provide us with the potential ability to target proteins specifically aiding to the survival of cancer. Some of these mutations have been targeted successfully and have prolonged life in other cancers, e.g.CML and lung cancer. However, clinical trials have revealed that certain targeted therapies, such as avastin and cetuximab, do not prolong life in glioblastoma. Glioblastoma is known for its highly mutated DNA, its highly migratory phenotype, and its high heterogeneity, making this tumor difficult to target. One goal is to find an essential oncoprotein that the tumor is addicted to, a theory known as oncogene addiction, to target and eliminate the cells upon inactivation of the oncogene. Another is to find a protein that is only expressed by the tumor cell, known as a tumor specific antigen, to reduce toxicity levels of therapy. Unfortunately, these tasks are not as easily accomplished as they were originally theorized. MERTK, a receptor tyrosine kinase, is a protein that is essential in glioblastoma with regard to signaling for cellular migration, pro-survival and pro-proliferative signaling pathways. Targeting MERTK is promising because it is aberrantly expressed in 90% of glioblastoma patient samples tested. However, taking into consideration the failed clinical trials for monotherapy against EGFR, another receptor tyrosine kinase targeted in GBM, combination therapy may provide a better approach in the treatment of GBM. Two approaches were tested. One approach combined therapy of MERTK inhibition with either chemotherapy or autophagy manipulation. The second approach is to stimulate the immune system alongside EGFR inhibition, with the hope of enabling a greater response in patients.

Author: Anne Le
Publisher: Springer
ISBN: 331977736X
Category : Medical
Languages : en
Pages : 186

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Book Description
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.