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Author: Publisher: ISBN: Category : Biomimetic polymers Languages : en Pages : 492
Book Description
The synthesis of catalytically active polymers by MIP techniques results in tailor-made synthetic polymers, which are capable of subsequent molecular recognition of particular molecules. Even though considerable efforts have been expanded in the past to produce effective enzyme mimetic MIPs, catalytic rates and specificities have still been significantly lower, when compared to natural enzymes. The main reasons have been the use of unsuitable templates (i.e. those lacking particular molecular geometrics or stereochemistries) and suboptimal orientation of the appropriate active sites in the polymer matrix. Since the catalytic activity of a MIP is mediated through the cavity sites created in the macromolecular entity of the MIP, the generation of these active sites should be achieved through a particular polymerisation chemistry and utilising specific templates. Since control over the molecular architecture of the cavity sites in the MIPs is the decisive factors for those polymers to exhibit efficient catalytic activity and selectivity, templates that feature the appropriate functional and geometrical specification have to be designed and synthesised. A significant approach for successful achievement of this therefore should use the catalytic mechanism of the enzymes as a guideline. It has been described that the catalytic rate of biological and chemical reactions by enzymes is achieved when enzymes lower the activation energy of the reaction. This is achieved due to the differential binding energy of the substrate in its transition state (TS) and its ground state (GS). In this case, the higher binding affinity of the enzyme to the TS of the substrate compared to its GS enables the activation energy of the reaction to be lowered, and hence enhances the rate of the reaction.
Author: Publisher: ISBN: Category : Biomimetic polymers Languages : en Pages : 492
Book Description
The synthesis of catalytically active polymers by MIP techniques results in tailor-made synthetic polymers, which are capable of subsequent molecular recognition of particular molecules. Even though considerable efforts have been expanded in the past to produce effective enzyme mimetic MIPs, catalytic rates and specificities have still been significantly lower, when compared to natural enzymes. The main reasons have been the use of unsuitable templates (i.e. those lacking particular molecular geometrics or stereochemistries) and suboptimal orientation of the appropriate active sites in the polymer matrix. Since the catalytic activity of a MIP is mediated through the cavity sites created in the macromolecular entity of the MIP, the generation of these active sites should be achieved through a particular polymerisation chemistry and utilising specific templates. Since control over the molecular architecture of the cavity sites in the MIPs is the decisive factors for those polymers to exhibit efficient catalytic activity and selectivity, templates that feature the appropriate functional and geometrical specification have to be designed and synthesised. A significant approach for successful achievement of this therefore should use the catalytic mechanism of the enzymes as a guideline. It has been described that the catalytic rate of biological and chemical reactions by enzymes is achieved when enzymes lower the activation energy of the reaction. This is achieved due to the differential binding energy of the substrate in its transition state (TS) and its ground state (GS). In this case, the higher binding affinity of the enzyme to the TS of the substrate compared to its GS enables the activation energy of the reaction to be lowered, and hence enhances the rate of the reaction.
Author: Börje Sellergren Publisher: Elsevier Science Limited ISBN: 9780444828378 Category : Science Languages : en Pages : 557
Book Description
This book is divided into 5 sections starting with an historic perspective and fundamental aspects on the synthesis and recognition by imprinted polymers. The second section contains 8 up-to-date overview chapters on current approaches to molecular and ion imprinting. This is followed by two chapters on new material morphologies and in the last two sections various analytical applications of imprinted polymers are given, with the last four chapters devoted to the promising field of imprinted polymers in chemical sensors. The authors of this volume have widely different backgrounds; mainly polymer chemistry, organic chemistry, biochemistry and analytical chemistry, which means that this book has an interdisciplinary character and should appeal to a broad audience.
Author: Lei Ye Publisher: CRC Press ISBN: 9814310999 Category : Science Languages : en Pages : 288
Book Description
Molecular imprinting is one of the most efficient methods to fabricate functional polymer structures with pre-defined molecular recognition selectivity. Molecularly imprinted polymers (MIPs) have been used as antibody and enzyme mimics in a large number of applications. The outstanding stability and straightforward preparation make MIPs ideal substitutes for biologically derived molecular recognition materials, especially for development of affinity separation systems, chemical sensors and high selectivity catalysts. New MIP materials are being increasingly applied to solve challenging problems in environmental sciences, food safety control, biotechnology and medical diagnostics. Development in molecular imprinting research over the past decade has enabled tailor-designed molecular recognition sites to be created in synthetic materials with physical dimensions in the micro- and nano-regime. The new breakthroughs in MIP synthesis/fabrication have brought in many unprecedented functions of the micro- and nano-structured polymers. The aim of this review volume is to introduce to the readers the new developments in molecularly imprinted micro- and nano-structures, and the new applications that have been made possible with the new generation of imprinted materials.
Author: Meenakshi Singh Publisher: Elsevier ISBN: 0323914179 Category : Technology & Engineering Languages : en Pages : 464
Book Description
Molecularly Imprinted Polymers (MIPs): Commercialization Prospects guides the reader through the various steps in the conceptualization, design, preparation and innovative applications of molecularly imprinted polymers while also demystifying the challenges relating to commercialization. Sections cover molecularly imprinted polymers, design, modeling, compositions and material selection. Other sections describe novel methods and discuss the challenges relating to the use of molecularly imprinted polymers in specific application areas. The final chapters of the book explore the current situation in terms of patents and commercialized materials based on MIPs, as well as prospects and possible opportunities. This is a valuable resource for all those with an interest in the development, application, and commercialization of molecularly imprinted polymers, including researchers and advanced students in polymer science, polymer chemistry, nanotechnology, materials science, chemical engineering, and biomedicine, as well as engineers, scientists and R&D professionals with an interest in MIPs for advanced applications. Covers all stages of molecular imprinting, from conceptualization, modeling, and solvent choice, to extraction, monomer composition and miniaturization Offers a unique focus on commercialization, examining the current situation and addressing barriers to further commercialization Includes state-of-the-art, novel approaches for the utilization of biopolymers and their nanoparticles as imprinting matrixes and numerical calculations in the design of MIPs
Author: Karsten Haupt Publisher: Springer Science & Business Media ISBN: 3642284205 Category : Science Languages : en Pages : 362
Book Description
Molecularly Imprinted Polymers, by Karsten Haupt, Ana V. Linares, Marc Bompart und Bernadette Tse Sum Bui.- Physical Forms of MIPs, by Andrea Biffis, Gita Dvorakova und Aude Falcimaigne-Cordin.- Micro and Nanofabrication of Molecularly Imprinted Polymers, by Marc Bompart, Karsten Haupt und Cédric Ayela.- Immuno-Like Assays and Biomimetic Microchips, by M. C. Moreno-Bondi, M. E. Benito-Peña, J. L. Urraca und G. Orellana.- Chemosensors Based on Molecularly Imprinted Polymers, by Subramanian Suriyanarayanan, Piotr J. Cywinski, Artur J. Moro, Gerhard J. Mohr und Wlodzimierz Kutner.- Chromatography, Solid-Phase Extraction, and Capillary Electrochromatography with MIPs, by Blanka Tóth und George Horvai.- Microgels and Nanogels with Catalytic Activity, by M. Resmini, K. Flavin und D. Carboni.
Author: Theodore Quinn Publisher: Nova Publishers ISBN: 9781634859516 Category : TECHNOLOGY & ENGINEERING Languages : en Pages : 200
Book Description
In the past years, there has been growing interest in the development of molecularly imprinted polymers (MIPs). Molecular imprinting technology have been widely used in different fields including pharmaceutical biotechnological and chemical industries, water purification and food and environment analysis. This book discusses the challenges, uses and prospects of MIPs. Chapter One provides an overview of the different applications of the molecularly imprinted polymers in the field of food science. Chapter Two highlights some of the examples of MIP synthesis and use, without covering the extensive literature available and providing a broad view of the field. Chapter Three analyzes trends in the molecular imprinting of small molecules.
Author: Carmen Alvarez-Lorenzo Publisher: Smithers Rapra Technology ISBN: 9781847359605 Category : Science Languages : en Pages : 400
Book Description
Molecular imprinting technology has become a relevant tool for the synthesis of polymeric materials with the unique feature of being able to recognise specific target molecules and to bind them preferably among many others. Such an outstanding property makes molecularly imprinted polymer(s) (MIP) well suited for a wide range of applications in fields as diverse as analytical techniques, bioremediation, catalysis or drug delivery. Information regarding MIP has exponentially increased in recent years, being collected in a large variety of scientific journals, monographs and proceedings. The aim of this Handbook is to provide an overview of the state of the art of MIP by organising the information in an educational and practical way, with useful guidelines for newcomers to the field regarding monomer selection, polymerisation conditions and MIP conditioning for each given purpose. This is accompanied by updated knowledge from papers published over the past few years that may be of interest for senior researchers in the field. An analysis of the historical evolution of MIP, and of their future perspectives and trends is also offered. The Handbook has been structured in eight chapters written by distinguished experts in the various areas of MIP application. Using a direct language, graduate students and novel researchers may find, within these chapters, friendly pathways to enter the world of molecular imprinting. Trained professionals can also take benefit from the critical review of recent advances on the implementation of alternative approaches to prepare and use MIP, in order to optimise their performance in already established fields, but also to open novel fields of application.
Author: Faizatul Shimal Binti Mehamod Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
Molecular imprinting, a technique for the preparation of polymeric materials that are capable of molecular recognition in various applications, is developing rapidly. In this study, work was directed towards the synthesis of novel molecularly imprinted polymers (MIPs) that enable high performance separations in analytical science and other fields. Furthermore, a new method of MIP synthesis, using controlled radical polymerisation, was explored, and a computational modelling method evaluated which enables the prediction of binding isotherms of MIPs in a qualitative manner prior to synthesis. The synthesis of ketamine imprinted polymers via a conventional approach is described. The overall aim of this study was to develop a new analytical method, Molecularly Imprinted Liquid Chromatography-Tandem Mass Spectrometry (MILC-MS/MS) for the detection of ketamine in hair. A key requirement was the production of ketamine imprinted polymer particulates in an appropriate physical format for the direct packing of the imprinted materials into chromatography columns, which were then hyphenated to a mass spectrometer. Several polymers were synthesised and their molecular recognition properties characterised using liquid chromatography techniques. A new analytical method for ketamine was set in place. iii The utility of controlled radical polymerisation in the preparation of MIPs was explored. The controlled radical polymerisation method of choice was reversible addition-fragmentation chain transfer (RAFT). The synthesis and use of a RAFT agent (CPDB) in MIP syntheses is described. It was discovered that polymers prepared via RAFT polymerisations enhanced the chromatographic performance of MIPs. Through a collaborative research study, an aim was to develop and evaluate a computational model for MIPs which predicted, in silico, the qualitative binding isotherms of a MIP. Real imprinted polymers were synthesised and their binding isotherms measured in order to test the validity of the predictive model. Pyridine imprinted and non-imprinted polymers were synthesised in monolithic form. There was good agreement between the predicted and experimental binding data.
Author: Publisher: Elsevier ISBN: 0444642676 Category : Science Languages : en Pages : 392
Book Description
Mip Synthesis, Characteristics and Analytical Application, Volume 86 in the Comprehensive Analytical Chemistry series, highlights advances in the field, with this new volume presenting interesting chapters on synthesis and polymerization techniques of molecularly imprinted polymers, Solid phase extraction technique as a general field of application of molecularly imprinted polymer materials, Advanced artificially receptor- based sorbents for solid phase extraction using molecular imprinting technology: a new trend in food analysis, Application of molecularly imprinted polymers in microextraction and solventless extraction techniques, Magnetic molecularly imprinted microspheres – analytical approach, Surface Imprinted Micro- and Nanoparticles, and much more. Contains a valuable source of information on the wide spectrum of application fields of molecularly imprinted polymers as a green sorption medium Describes the application potential of currently molecular imprinting technologies, associated with the solid phase extraction techniques, magnetic imprinted microspheres, sorbents in mass spectrometry, and imprinted polymer electrochemical sensors
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Author: Börje Sellergren
Author: Lei Ye
Author: Meenakshi Singh
Author: Karsten Haupt
Author: Theodore Quinn
Author: Carmen Alvarez-Lorenzo
Author: Faizatul Shimal Binti Mehamod
Author: Börje Sellergren
Author: