Author: Jurgen Brockmoller Publisher: Frontiers Media SA ISBN: 2889740293 Category : Science Languages : en Pages : 145
Book Description
Around one third of all biologically relevant small molecules are organic cations. These include endogenous substances like catecholamines and other neurotransmitters, toxins and drugs designed to affect signaling processes. The organic cation transporter 1 (OCT1) is among the strongest expressed membrane transporters at the sinusoidal (blood-facing) side of liver cells and contributes substantially to the clearance of the blood from numerous organic cations. A most striking feature of OCT1 is its pronounced genetic diversity. Between 1 and 10% of all human populations have little to no OCT1 activity. With several of the OCT1 substrates up to 10% of Europeans are functionally OCT1 deficient. Apparently, the lack of OCT1 do not lead to apparent substantial pathological changes in these individuals. It thus appears that this transporter is not essential to human life, but does it means that OCT1 is irrelevant? In the last 25 years since the first cloning of this transporter, data on its pharmacological and physiological relevance is steadily accumulating. Numerous clinically relevant drugs (e.g. metformin, morphine, fenoterol, sumatriptan, tramadol and tropisetron) have been shown to be substrates of OCT1, and OCT1 deficiency has been shown to affect the pharmacokinetics, efficacy, or toxicity of these drugs. Also vitamin B1 has been shown to be a substrate of OCT1, and in genetically modified mice OCT1 substantially modulated hepatic lipid metabolism, total body fat and systemic glucose and lipid concentrations. Still, numerous important questions remain unsolved: For which drugs, toxins, or other endogenous or exogenous substances is OCT1 relevant? How can we predict the relevance of OCT1 from in vitro studies? What determines the substrate selectivity of OCT1 in comparison to other transporters or transport processes for organic cations? What regulates the expression of OCT1 in the liver and possibly in other tissues? What is the impact of OCT1 variation in different areas of medicine, including the therapies for cancer as well as for pulmonary, cardiovascular, or neurological diseases? How can evolutionary biology contribute to a better understanding of the roles of OCT1? And, importantly, what types of research are likely to significantly further the knowledge on OCT1 in the next decades?
Author: Jordan Tannahill Publisher: Coach House Books ISBN: 177056411X Category : Social Science Languages : en Pages : 161
Book Description
How dull plays are killing theatre and what we can do about it. Had I become disenchanted with the form I had once fallen so madly in love with as a pubescent, pimple-faced suburban homo with braces? Maybe theatre was like an all-consuming high school infatuation that now, ten years later, I saw as the closeted balding guy with a beer gut he’d become. There were of course those rare moments of transcendencethat kept me coming back. But why did they come so few and far between? A lot of plays are dull. And one dull play, it seems, can turn us off theatre for good. Playwright and theatre director Jordan Tannahill takes in the spectrum of English-language drama – from the flashiest of Broadway spectacles to productions mounted in scrappy storefront theatres – to consider where lifeless plays come from and why they persist. Having travelled the globe talking to theatre artists, critics, passionate patrons and the theatrically disillusioned, Tannahill addresses what he considers the culture of ‘risk aversion’ paralyzing the form. Theatre of the Unimpressed is Tannahill’s wry and revelatory personal reckoning with the discipline he’s dedicated his life to, and a roadmap for a vital twenty-first-century theatre – one that apprehends the value of ‘liveness’ in our mediated age and the necessity for artistic risk and its attendant failures. In considering dramaturgy, programming and alternative models for producing, Tannahill aims to turn theatre from an obligation to a destination. ‘[Tannahill is] the poster child of a new generation of (theatre? film? dance?) artists for whom "interdisciplinary" is not a buzzword, but a way of life.’ —J. Kelly Nestruck, Globe and Mail ‘Jordan is one of the most talented and exciting playwrights in the country, and he will be a force to be reckoned with for years to come.’ —Nicolas Billon, Governor General's Award–winning playwright (Fault Lines)
Author: Cristina Bechtler Publisher: Jrp Ringier ISBN: 9783037643501 Category : Architecture, Modern Languages : en Pages : 0
Book Description
This volume compiles ideas and projects from well-known artists, architects, designers, filmmakers and researchers on mountainous regions not only in Switzerland, but worldwide. It includes writings by Vito Acconci, Doug Aitken, Ron Arad, Nairy Baghramian and Jan von Brevern, as well as a discussion on architect Bruno Taut's "Crystal Chain Letters."
Author: Nick Lane Publisher: ISBN: 9781781250372 Category : Cells Languages : en Pages : 0
Book Description
A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.
Author: Julia Cameron Publisher: Penguin ISBN: 1101156880 Category : Self-Help Languages : en Pages : 295
Book Description
"With its gentle affirmations, inspirational quotes, fill-in-the-blank lists and tasks — write yourself a thank-you letter, describe yourself at 80, for example — The Artist’s Way proposes an egalitarian view of creativity: Everyone’s got it."—The New York Times "Morning Pages have become a household name, a shorthand for unlocking your creative potential"—Vogue Over four million copies sold! Since its first publication, The Artist's Way phenomena has inspired the genius of Elizabeth Gilbert and millions of readers to embark on a creative journey and find a deeper connection to process and purpose. Julia Cameron's novel approach guides readers in uncovering problems areas and pressure points that may be restricting their creative flow and offers techniques to free up any areas where they might be stuck, opening up opportunities for self-growth and self-discovery. The program begins with Cameron’s most vital tools for creative recovery – The Morning Pages, a daily writing ritual of three pages of stream-of-conscious, and The Artist Date, a dedicated block of time to nurture your inner artist. From there, she shares hundreds of exercises, activities, and prompts to help readers thoroughly explore each chapter. She also offers guidance on starting a “Creative Cluster” of fellow artists who will support you in your creative endeavors. A revolutionary program for personal renewal, The Artist's Way will help get you back on track, rediscover your passions, and take the steps you need to change your life.
Author: Jorge Acevedo Publisher: Abingdon Press ISBN: 1426769857 Category : Religion Languages : en Pages : 142
Book Description
What behaviors do highly vital congregations have in common? How can all congregations move toward greater vitality? In Vital: Churches Changing Communities and the World, Jorge Acevedo passionately and effectively reveals how Grace Church in Cape Coral, Florida, has developed behaviors that result in vital and fruitful ministry. Focusing on spiritual pastoral leadership, lay leadership development, worship, small groups, and service and mission, Acevedo both inspires and coaches. He helps leaders of congregations act in their own contexts to develop behaviors essential to vitality, as identified by the recent study of 32,000 United Methodist congregations. The book includes brief summaries of learnings from the research and stories from other congregations illustrating vital behaviors in different settings. Approximately 15% of the 32,228 churches (4,961 churches) scored high in vitality based on the vitality index. What this means is that 15% of our churches have figured out some way to remain highly vital in spite of the fact that 85% have not. What this means is that we cannot assign all the blame for our congregational demise at the feet of the “institution” of the church. 4961 congregations have figured out ways to prevail in spite of our denominational condition. To me this is hopeful and promising! This book is my best attempt for us to learn from the 15% of United Methodist Churches that are vital, growing and prevailing. Jorge Acevedo
Author: Michael R. Strain Publisher: Templeton Foundation Press ISBN: 1599475588 Category : Political Science Languages : en Pages : 169
Book Description
Populists on both sides of the political aisle routinely announce that the American Dream is dead. According to them, the game has been rigged by elites, workers can’t get ahead, wages have been stagnant for decades, and the middle class is dying. Michael R. Strain, director of economic policy studies at the American Enterprise Institute, disputes this rhetoric as wrong and dangerous. In this succinctly argued volume, he shows that, on measures of economic opportunity and quality of life, there has never been a better time to be alive in America. He backs his argument with overwhelming—and underreported—data to show how the facts favor realistic optimism. He warns, however, that the false prophets of populism pose a serious danger to our current and future prosperity. Their policies would leave workers worse off. And their erroneous claim that the American Dream is dead could discourage people from taking advantage of real opportunities to better their lives. If enough people start to believe the Dream is dead, they could, in effect, kill it. To prevent this self-fulfilling prophecy, Strain’s book is urgent reading for anyone feeling the pull of the populists. E. J. Dionne and Henry Olsen provide spirited responses to Strain’s argument.
Author: Anthony Marra Publisher: Random House ISBN: 1448130859 Category : Fiction Languages : en Pages : 420
Book Description
*** Granta Best of Young American Novelists 2017 *** In a snow-covered village in Chechnya, eight-year-old Havaa watches from the woods as her father is abducted in the middle of the night by Russian soldiers. Their life-long friend and neighbour, Akhmed, has also been watching, and when he finds Havaa he knows of only one person who might be able to help. For tough-minded doctor Sonja Rabina, it’s just another day of trying to keep her bombed-out, abandoned hospital going. When Akhmed arrives with Havaa, asking Sonja for shelter, she has no idea who the pair are. But over the course of five extraordinary days, Sonja’s world will shift on its axis, revealing the intricate pattern of connections that binds these three unlikely companions together and unexpectedly decides their fate. 'A Constellation of Vital Phenomena is simply spectacular' Ann Patchett
Author: Karen Glass Publisher: ISBN: 9781700769800 Category : Languages : en Pages : 186
Book Description
Charlotte Mason looked at the world and saw that it was governed by universal laws, such as the law of gravity. Then she wondered. What if there were similar laws that governed the way people learn? If we knew what those laws were, we'd be able to pursue education along the most promising lines . She devoted her life to finding the key principles of education and then developing methods to make the most of them. The result is a comprehensive picture of living and learning that breathes life into education at every level--from babyhood to the adult years. It's not a rote system, but a flexible set of ideas that keep education in focus. These principles are for everyone concerned with teaching and learning. They are no more difficult to implement than the principle of gravity which allows you to walk, run, and even--when you know what you are doing--to soar.
Author: Jurgen Brockmoller
Author: Jordan Tannahill
Author: Cristina Bechtler
Author: Nick Lane
Author: Julia Cameron
Author: Jorge Acevedo
Author: Michael R. Strain
Author: Anthony Marra
Author: Karen Glass
Author: