Nora Virus Infection of Drosophila Melanogaster PDF Download

Author: Ethan Cordes
Publisher:
ISBN:
Category : Drosophila melanogaster
Languages : en
Pages : 138

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Author: Wilfredo Lopez
Publisher:
ISBN:
Category : Drosophila melanogaster
Languages : en
Pages : 176

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Author: Kellie D. Licking-Murray
Publisher:
ISBN:
Category : Drosophila melanogaster
Languages : en
Pages : 166

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Author: Mazen Habayeb
Publisher:
ISBN: 9789172647817
Category :
Languages : en
Pages : 39

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Author: Farzana Khan Perveen
Publisher: BoD – Books on Demand
ISBN: 9535138537
Category : Technology & Engineering
Languages : en
Pages : 270

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Book Description
This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.

Author: Brennen Lee
Publisher:
ISBN:
Category :
Languages : en
Pages : 86

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Author: Xiaohong Wang
Publisher:
ISBN:
Category : Drosophila melanogaster
Languages : en
Pages : 382

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Author: Safia Deddouche
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Viral infections continue to be a major cause of morbidity and mortality world-wide. In particular, the past three decades have witnessed the onset of some 25 new viral diseases. Moreover recent outbreaks such as Chikungunya fever in La Réunion demonstrate the enormous public health problem associated with arthropod-borne virus infections. At this stage, our understanding of how the vector responds to virus infection is very limited. The goal of my PhD studies was to use Drosophila melanogaster as a model to study the host response of insects to virus infection. In flies like in mammals, viral infection triggers the expression of a large number of genes. I have provided genetic evidence that the inducible gene Vago limits viral replication. This was the first demonstration that an inducible molecule controls viral replication in drosophila. Interestingly, I have shown that Vago induction is dependant of the Dicer-2 molecule. I also note that Dicer-2 belongs to the same DEXD/H-box helicase family as RIG-I like receptors, which sense viral infection and mediate interferon induction in mammals. I posit that this family represents an evolutionary conserved set of sensors, which detect viral nucleic acids and direct antiviral responses. My work points out that the well known RNaseIII enzyme Dicer-2 plays a dual role during infection: (i) a direct role counteracting viral replication by cutting viral RNA and (ii) a sensing role that triggers antiviral gene expression in Drosophila.

Author: Ronald P. van Rij
Publisher: Humana Press
ISBN: 9781617790362
Category : Medical
Languages : en
Pages : 0

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Book Description
Viruses and RNAi share an intricate relationship at many levels. RNAi is an important antiviral defense mechanism in plants and invertebrates, microRNAs – of viral or cellular origin – affect many aspects of virus biology, and replication of many, if not all, mammalian viruses can be suppressed by RNAi. Antiviral RNAi: Concepts, Methods, and Applications provides a collection of protocols for the analysis of viral small RNAs and natural antiviral RNAi responses as well as for the development and optimization of RNAi-based antiviral drugs. As RNAi is a central regulatory mechanism in the cell, the methods in this volume can also be applied out of the context of a virus infection. Divided into five convenient parts, this detailed volume reviews important basic concepts in the field of antiviral RNAi, provides experimental and bio-informatic tools for the analysis of small silencing RNAs, covers methods to biochemically dissect RNAi-based antiviral defense and viral counter-defense mechanisms, describes methods for the design, expression, and delivery of therapeutic antiviral siRNAs, and finally presents genome-wide RNAi approaches for the identification of factors involved in virus replication. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Antiviral RNAi: Concepts, Methods, and Applications serves as an ideal guide for both novice and experienced researchers alike striving to dissect the role of RNAi in the viral life cycle or to further boost the development of novel therapeutics and experimental tools based on RNAi technology.

Author: Federica Sandrelli
Publisher:
ISBN: 9781071602591
Category : Entomology
Languages : en
Pages : 246

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Book Description
This volume details methods and protocols necessary to further the study of insect immunity. Chapters guide readers through up-to-date genomic and transcriptomic approaches, insect samples for proteomic analysis, hemocytes in Drosophila, cellular response in Lepidoptera, insect AMPs, manipulate the composition of mosquito microbiota, viral infections in insects, infections by entomopathogenic nematodes, immune response following oral infections, and protocols to to monitor the effect of septic infections with human pathogens using B. mori as a model. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Immunity in Insects aims to ensure successful results in the further study of this vital field.Incl .