Author: Publisher:
ISBN:
Category : Diseases
Languages : en
Pages : 234
Book Description
Non-human Primate Models for Human Disease and Immunobiology
Author: Immunological Reviews
Author: Chimpanzees in Biomedical and Behavioral Research
Author: National Research CouncilPublisher: National Academies Press
ISBN: 0309220424
Category : Science
Languages : en
Pages : 200
Book Description
For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.
Nonhuman Primate Models For Human Diseases
Author: W. Richard DukelowPublisher: CRC Press
ISBN: 135109193X
Category : Medical
Languages : en
Pages : 313
Book Description
While research has enabled us to better understand the nonhuman primates, they have repaid that by repaid that by providing medical scientists with important tools for the study of human biomedical problems. This book is about those research tools. The book was designed by identifying areas of human medical research that are under intensive research study today. Authors were then selected based on their expertise at using nonhuman primates as models for the human condition. Each was asked to use as comparative an approach as models for the human condition. Each was asked to use a comparative an approach as possible, to provide the reader with knowledge relating to the usefulness of various nonhuman primate species to each specific research area.
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
Author: Joerg BluemelPublisher: Academic Press
ISBN: 012417146X
Category : Medical
Languages : en
Pages : 716
Book Description
The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. - Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more - Includes practical examples on techniques and methods to guide your daily practice - Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes
Nonhuman Primate Models in Preclinical Research
Author: Huifang ChenPublisher: Nova Science Publishers
ISBN: 9781536199222
Category : Science
Languages : en
Pages : 272
Book Description
"Due to the phylogenetic relationship and close genetic and biological similarities with humans, non-human primates (NHP) are regularly used in biomedical and behavioural research. However, because of their highly developed cognitive abilities and social skills, the use of these animals in biomedical research is debated more and more. Although it is acknowledged that in specific research areas NHP are still essential, it is recognized that the use of these animals can only be done under strict conditions under the most optimal welfare aspects. Welfare aspects include housing conditions, non-invasive methods and application of the 3Rs policy. Although many refinement methods have been described in nationally and internationally accepted guidelines on animal laboratory practice, recognition of the guidelines is unfortunately not universal. The present book covers a wide range of NHP models in preclinical research and welfare issues. The following chapters will cover: refinement of the use of NHP in biomedical research; NHP ethics and regulations in Europe; biological basis differences in the human and NHP; the major histocompatibility complex (MHC) immunology in NHP; stem cell biology in NHP; neuro and gliogenesis in an NHP ischemia stroke model; NHP models in autoimmune disease, organ transplantation and infectious disease research; viral diseases in NHP; NHP models in Parkinson's disease, in neurodegenerative disorders research and in cardio-cerebrovascular disease research; islet transplantation; ophthalmic diseases research and neurophysiology in NHP; transgenic engineering in NHP; NHP models of cancers; NHP models in respiratory disease research; NHP models in clinical and non-clinical pharmacology; NHP models in lung transplantation; and aging research in NHP. This book encapsulates a large volume of knowledge scientists have achieved in the field of nonhuman primate models in preclinical research. The editors have invited experts from the United States, Canada, and Europe to contribute 23 chapters in their respective fields of their expertise"--
Nonhuman Primate Models in Biomedical Research: State of the Science and Future Needs
Author: National Academies Of Sciences EngineeriPublisher: National Academies Press
ISBN: 9780309699365
Category : Medical
Languages : en
Pages : 0
Book Description
Nonhuman primates represent a small fraction of animals used in biomedical research, but they remain important research models due to their similarities to humans with respect to genetic makeup, anatomy, physiology, and behavior. Limitations in the availability of nonhuman primates have been exacerbated by the COVID-19 pandemic and recent restrictions on their exportation and transportation, impacting National Institutes of Health (NIH)-funded research necessary for both public health and national security. Additionally, there is continued interest in understanding whether and how nonanimal models can be used to answer scientific questions for which nonhuman primates are currently used. At the direction of the U.S. Congress, NIH asked the National Academies of Sciences, Engineering, and Medicine to convene an expert committee to conduct a landscape analysis of current and future use of nonhuman primates in NIH-supported biomedical research, as well as opportunities for new approach methodologies to complement or reduce reliance on nonhuman primate models. This report provides the committee findings and conclusions.
Nonhuman Primate Models in Preclinical Research
Author: Huifang ChenPublisher: Nova Science Publishers
ISBN: 9781536199147
Category : Nature
Languages : en
Pages : 0
Book Description
Despite many encouraging developments in the field of animal-free technologies, well-defined animal models are still needed to study fundamental properties of human diseases and to develop new prophylactic and therapeutic treatments against human diseases. Non-human primates (NHP) make up only a small, but important, part of the total number of animals used in biomedical and preclinical research. Due to their close phylogenetic relationship and the shared susceptibility to many human diseases, NHP can provide important research models to study these diseases and, as such, play a critical role in the advancement of various areas in the medical field. Studies in NHP have contributed to our understanding of various diseases and fundamental biological phenomena and they continue to be important in the development of new therapies, treatments, drugs and vaccines. Moreover, NHP models also contribute to our general knowledge of the processes that underlie non-disease and disease conditions. Important areas where NHP can provide important information include (emerging) infectious diseases, organ transplantation, neurological and aging-related disorders. Although not covered in this book due to time constraints, the need for, and benefits of, NHP models has been demonstrated most recently in the SARS-CoV-2 pandemic. The present book is the second of two volumes and covers important disease areas where NHP are used as model species. This volume includes different chapters on NHP models in infectious diseases, aging, neurodegenerative disorders, organ transplantation and cancer.
Nonhuman Primates in Biomedical Research,Two Volume Set
Author: Christian R. AbeePublisher: Academic Press
ISBN: 9780124158337
Category : Science
Languages : en
Pages : 0
Book Description
The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The publication emphasizes the biology and management, diseases, and biomedical models for nonhuman primate species most commonly used in research. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. The Biology and Management volume provides basic information on the natural biology of nonhuman primates and the current state of knowledge regarding captive management. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Now in four color throughout, making the book more visually stimulating to enhance learning and ease of use Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in biomedical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information
Nonhuman Primates in Biomedical Research
Author: Christian R. AbeePublisher: Academic Press
ISBN: 0123813662
Category : Medical
Languages : en
Pages : 868
Book Description
A comprehensive, up-to-date review of the use of nonhuman primates in biomedical research, emphasising the biology and management, diseases, and biomedical models for nonhuman primate species most commonly used in research.