Author: William Fishman Publisher: Elsevier ISBN: 0323143083 Category : Science Languages : en Pages : 713
Book Description
Metabolic Conjugation and Metabolic Hydrolysis, Volume II, provides an extension and further development of the themes introduced in Volume I in which the subject matter dealt either separately or in combination with the compound undergoing conjugation, the conjugate itself, the conjugating radical, and enzymic hydrolysis of the conjugate. Increased attention is also given to systems in which metabolic conjugation and metabolic hydrolysis interdigitate with each other. The book begins with studies on the role of conjugation in the biliary excretion of organic compounds; cholic acid and its conjugation; biliary secretion and intestinal metabolism and absorption; and the metabolic conjugation and hydrolysis of steroids and their conjugates, as observed in the fetoplacental unit of human pregnancy. Subsequent chapters cover the fabrication through physiological metabolic conjugation of macromolecules of glycoproteins and mucopolysaccharides; the biosynthesis of glycolipids (sphingolipids); the metabolic hydrolysis of hexosaminide linkages; ß-glucuronidases; the hydrolysis of sphingolipids; and mercapturic acid formation.
Author: Takahiko Akiyama Publisher: John Wiley & Sons ISBN: 1119736412 Category : Science Languages : en Pages : 798
Book Description
Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.
Author: John D. Roberts Publisher: ISBN: 9780805383218 Category : Chemistry, Organic Languages : en Pages : 1596
Book Description
Introduction what is organic chemistry all about?; Structural organic chemistry the shapes of molecules functional groups; Organic nomenclature; Alkanes; Stereoisomerism of organic molecules; Bonding in organic molecules atomic-orbital models; More on nomenclature compounds other than hydrocarbons; Nucleophilic substitution and elimination reactions; Separation and purification identification of organic compounds by spectroscopic techniques; Alkenes and alkynes. Ionic and radical addition reactions; Alkenes and alkynes; Oxidation and reduction reactions; Acidity or alkynes.
Author: Bernard Testa Publisher: John Wiley & Sons ISBN: 9783906390253 Category : Science Languages : en Pages : 808
Book Description
Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
Author: William Fishman
Author: Takahiko Akiyama
Author: John D. Roberts
Author: Roy Frederick Herrman
Author: Bernard Testa
Author: Walton B. Sinclair
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