Nitric Oxide in Pathophysiology and Treatment of Pulmonary Hypertension PDF Download

Author: Junko Maruyama
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages :

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Nitric Oxide in Pathophysiology and Treatment of Pulmonary Hypertension.

Author: Maria G. Belvisi
Publisher: Springer
ISBN: 3034884745
Category : Medical
Languages : en
Pages : 250

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Book Description
Nitric oxide is an endogenously produced gas with a wide range of biological effects and has been implicated in many physiological and pathophysiological processes. It is released by many cell types in various organs but is particularly important in the maintenance of normal lung function. Nitric oxide in exhaled breath has been identified as a marker for lung disease in some patients. Thus, it is appropriate to consider the lung separately for the role and functioning of nitric oxide. The authors identify key areas in the history, biochemistry, physiology, pathophysiology, immunology and clinical applications of nitric oxide in the lung. The contents of this book will be of particular importance to scientists and clinicians with an interest in lung disease. Moreover, the authors encompass state of the art opinions of and rational for the therapeutic potential of nitric oxide and its inhibitors.

Author: Gabor M. Rubanyi
Publisher: CRC Press
ISBN: 0203303725
Category : Science
Languages : en
Pages : 378

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Book Description
Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of research.

Author: Jean Elwing
Publisher: BoD – Books on Demand
ISBN: 9535111655
Category : Medical
Languages : en
Pages : 246

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Book Description
This volume presents overviews as well as in depth reviews of many aspects of the clinical presentation, pathophysiology, and treatment of Pulmonary Hypertension (PH) especially PH related to thromboembolic disease. Saleem Sharieff presents a comprehensive synopsis of the epidemiologic, clinical, histopathologic, and therapy of PAH. Next, Dimitar Sajkov, Bliegh Mupunga, Jeffrey J. Bowden, and Nikolai Petrovsky comprehensively review World Health Organization group III PH. The cellular and biochemical pathophysiology of PH are summarized by Rajamma Mathew. Specific mechanisms implicated in the pathogenesis of PH are presented by Junko Maruyama, Ayumu Yokochi, Erquan Zhang, Hirohumi Sawada, Kazuo Maruyama; and Aureliano Hernandez and Rafael A. Areiza. Jean Elwing and Ralph Panos discuss PH associated with acute thromboembolism. Mehdi Badidi and M Barek Naz discuss PH caused by chronic thromboembolic disease. Juan C. Grignola, Maria J. Ruiz-Cano, Juan P. Salisbury, Gabriela Pascal, Pablo Curbelo, and Pilar Escribano present the physiologic assessment of patients with chronic thromboembolic disease prior to surgical pulmonary endarterectomy and, finally, Henry Liu, Philip L. Kalarickal, Yiru Tong, Daisuke Inui, Michael J Yarborough, Kavitha A. Mathew, Amanda Gelineau, and Charles Fox comprehensively review the clinical perioperative evaluation and management of patients with PH due to chronic thromboembolic disease.

Author: Jochen Antel
Publisher: IOS Press
ISBN: 1607506017
Category : Medical
Languages : en
Pages : 116

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Book Description
Pulmonary hypertension is a fatal lung and heart disease. It is characterized by shortness of breath, fatigue and fainting. It is exacerbated by an increase of the pressure in the lung vasculature through exercise, leading to progressive worsening of hemodynamics, right ventricular hypertrophy, right heart insufficiency and finally right heart failure. This book focuses on pulmonary arterial hypertension, a rare and progressive subgroup of pulmonary hypertension, which is today incurable and terminally faal. Classification of pulmonary arterial hypertension, its pathology, and strategies for future therapy will be of interest both to those suffering from the disease and those who take care of patients. This volume will also engage physicians and other scientists contributing to an understanding of the pathophysiology of pulmonary arterial hypertension and attempting to extend life of humans with pulmonary arterial hypertension by developing causal and curative therapies.

Author: Yoshihiro Fukumoto
Publisher: Springer
ISBN: 9812878408
Category : Medical
Languages : en
Pages : 231

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Book Description
This book focuses on pulmonary arterial hypertension (PAH, Group 1) and chronic thromboembolic pulmonary hypertension (CTEPH, Group 4) among the various groups of pulmonary hypertension (PH) whose classification was updated into five major categories at the 5th World Symposium held in Nice, France, in 2013. Readers will find recent progress, methods, and up-to-date information on PH mechanisms, diagnostic images, and treatment in the management of PH.This volume, with contributions by leading researchers worldwide in the field , consists of five parts, starting with the fundamentals of PH, then pathophysiology and genetics, treatment, and right ventricular function.

Author: Joseph Loscalzo
Publisher: Springer Science & Business Media
ISBN: 1592590020
Category : Medical
Languages : en
Pages : 589

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Book Description
Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.

Author: E. Kenneth Weir, MD
Publisher: Blackwell Publishing
ISBN: 9780879936310
Category : Medical
Languages : en
Pages : 509

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Book Description
This publication is unique and ground breaking because no previous volume has focused on the mechanisms by which nitric oxide and oxygen radicals are involved in vascular pathophysiology. This book provides a current review of the use of nitric oxide to treat pulmonary hypertension, whether idiopathic or secondary to congenital heart disease. In this respect, it should be read by pediatric cardiologists. Respiratory care physicians and intensive-care specialists who study and treat ARDS or IRDS (adult or infant respiratory distress syndromes) would also benefit from this publication. This book is of particular interest to physiologists concerned with vascular biology or with the activity of nitric oxide and oxygen radicals.

Author: Kazuo Maruyama
Publisher:
ISBN:
Category : Electronic books
Languages : en
Pages : 0

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Book Description
Since the discovery of nitric oxide (NO) as a physiological substance produced in the endothelium, the impairment of endothelial NO production and reactivity of the pulmonary vasculature to NO have been described in animal models and patients with pulmonary hypertension (PH). The NO synthase-NO-cyclic guanosine monophosphate (cGMP) pathway is impaired in pulmonary arterial hypertension (PAH), pulmonary veno-occlusive disease (PVOD), pulmonary capillary hemangiomatosis (PCH), chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). Pioneering clinicians conceived that NO can be administered to the lung by inhalation and used this strategy to treat PH in humans and acute hypoxic PH in animal models. Inhaled NO (iNO) selectively decreases pulmonary arterial pressure with no changes in systemic arterial pressure. When iNO diffuses into the blood, it is converted to NO3,àí, thereby losing its vasodilatory effects. NO might then be recycled in hypoxic remote organs, where NO3,àí and NO2,àí are reduced to NO.¬†In the present chapter, the metabolic fate of iNO, based on previous air pollution research in Japan, is discussed. Then, we describe recent clinical applications of iNO in pediatric patients with various diseases, including bronchopulmonary dysplasia (BPD), persistent PH of neonates, and congenital diaphragmatic hernia (CDH). We also summarize the role of iNO in the catheterization lab, including acute vasoreactivity testing to assess prognosis, indications for specific PH therapy, and operability of congenital heart disease.

Author: Louis J. Ignarro
Publisher: Academic Press
ISBN: 0080525032
Category : Medical
Languages : en
Pages : 1023

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Book Description
Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. - Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide - Authored by world experts on nitric oxide - Includes an overview of basic principles of biology and chemical biology - Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense