Nitrite and Nitrate in Human Health and Disease PDF Download

Author: AnnMarie Kocher
Publisher: Springer Science & Business Media
ISBN: 1607616165
Category : Medical
Languages : en
Pages : 318

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Book Description
Nitrite and Nitrate in Human Health and Disease delivers a comprehensive review of nitrite and nitrate biology, from basic biochemistry to the complex physiology and metabolism of these two naturally occurring molecules in the human body. Well-organized and well referenced chapters cover the rich history of nitrite and nitrate, sources of exposure, and the physiological effects when consumed through foods containing nitrite and nitrate. The chapters are written by leading experts, all of whom share their research and perspectives in order to help define the context for benefits vs. any potential risks associated with nitrite and nitrate use, either through dietary ingestion or therapeutic dosing. This diverse collection of authors includes vascular biologists, physiologists, physicians, epidemiologists, cancer biologists, registered dieticians, chemists, and public health experts from five countries in both academia and government. Nitrite and Nitrate in Human Health and Disease provides a balanced view of nitric oxide biochemistry, and nitrite and nitrate biochemistry in physiology and in the food sciences.

Author: Jill Lincoln
Publisher: Cambridge University Press
ISBN: 9780521559775
Category : Medical
Languages : en
Pages : 60

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Book Description
Nitric oxide has a tantalizing role in health and disease: while many of its wide-ranging effects are well known, there remains much more to explore and to learn about the interactions of this fascinating molecule in physiological and pathophysiological processes. The volume reviews the myriad effects of nitric oxide as a chemical messenger in the central nervous system, peripheral nervous system, immune system and cardiovascular system. Furthermore, it provides a very practical introduction to the procedures and experimental protocols necessary to work with and study nitric oxide and its synthesizing enzyme, nitric oxide synthase, in the laboratory. In this respect the volume is unique, providing as it does a complete single-volume review of the role of nitric oxide in health and disease, and a very practical introduction to the methods and protocols involved in this intriguing and active area of biomedical research.

Author: Louis J. Ignarro
Publisher: Academic Press
ISBN: 0080525032
Category : Medical
Languages : en
Pages : 1023

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Book Description
Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. - Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide - Authored by world experts on nitric oxide - Includes an overview of basic principles of biology and chemical biology - Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense

Author:
Publisher: World Health Organization
ISBN:
Category : House & Home
Languages : en
Pages : 488

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Book Description
This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals involved in preventing health risks of environmental exposures, as well as specialists and authorities involved in the design and use of buildings, indoor materials and products. They provide a scientific basis for legally enforceable standards.

Author: Louis Ignarro
Publisher: St. Martin's Press
ISBN: 1429972459
Category : Health & Fitness
Languages : en
Pages : 276

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Book Description
Dr. Louis Ignarro discovered "the atom" of cardiovascular health--a tiny molecule called Nitric Oxide. NO, as it is known by chemists, is a signaling molecule produced by the body, and is a vasodilator that helps control blood flow to every part of the body. Dr. Ignarro's findings led to the development of Viagra. Nitric Oxide has a beneficial effect on the cardiovascular system as well. NO relaxes and enlarges the blood vessels, prevents blood clots that trigger strokes and heart attacks, and regulates blood pressure and the accumulation of plaque in the blood vessels. Dr. Ignarro's current research indicates that Nitric Oxide may help lower cholesterol by facilitating the actions of statin drugs like Lipitor. The goal of the regimen presented in NO More Heart Disease is to age proof the cardiovascular system, keeping the vascular network clean and elastic through enhanced NO productivity. The plan is easy-to-follow without extreme lifestyle adjustments, involving taking supplements to stimulate Nitric Oxide production, incorporating NO friendly food into the diet, and a moderate exercise program.

Author: Giuseppe Valacchi
Publisher: Springer Science & Business Media
ISBN: 1402083998
Category : Medical
Languages : en
Pages : 324

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Book Description
Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.

Author: Nathan S Bryan Phd
Publisher: Crescendo Publishing, LLC
ISBN: 9781948719001
Category :
Languages : en
Pages : 132

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Book Description
This book describes the role of nitric oxide in health and disease. Nitric oxide is one of the most important molecules produced by humans and is considered the "Holy Grail" in cardiovascular medicine. Loss of nitric oxide production is what leads to chronic disease. Without healthy NO (Nitric Oxide) levels you cannot be healthy and prevent the diseases of aging. Nitric oxide is the secret to anti-aging. This book reveals the latest scientific and medical information so that readers can understand the importance of nitric oxide for optimal health. This eye-opening book teaches how the body makes NO, what goes wrong in people that can't make NO, and perhaps most importantly, how to restore production of this "miracle molecule."

Author: Amedea Seabra
Publisher: Academic Press
ISBN: 0128134593
Category : Medical
Languages : en
Pages : 367

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Book Description
Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. - Provides background information about biology and chemistry of nitric oxide - Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications - Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity - Discusses the future of nitric oxide donors and their FDA approval

Author: Nathan S. Bryan
Publisher: DEStech Publications, Inc
ISBN: 1932078843
Category : Medical
Languages : en
Pages : 239

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Book Description
This book provides a scientific analysis of the effects of foods and nutrients on the NO pathway in humans. Contributors to the book clarify novel chemical and biochemical connections between dietary intake and nitric oxide, particularly in cases of NO deficiency. In this context, the book addresses how specific foods can restore nitric oxide production and bioactivity—without medical interventions. A variety of evidential data is presented showing how NO-rich dietary elements are implicated in disease prevention and modulation. The book offers new knowledge for food technologists, food manufacturers, nutrition researchers, and healthcare practitioners. From the Foreword by Louis J. Ignarro, Nobel Laureate in Physiology/Medicine "The body of work contained in this volume, linking NO to food and nutrition, may have revolutionary implications in terms of developing strategies to combat heart disease and many other contemporary diseases associated with NO deficiency. Proving that a natural and inexpensive regimen of foods rich in nitric oxide activity does restore NO homeostasis can have profound effects on human health…The research presented in this text provides an important expansion of NO work…(and) Dr. Nathan Bryan, the editor…is to be congratulated for…communicating new knowledge and assembling the world's experts in their fields."

Author: Nathan Bryan
Publisher:
ISBN: 9780615417134
Category : Health & Fitness
Languages : en
Pages : 170

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Book Description
Eighty-one million Americans have cardiovascular disease, the arterial damage that leads to the heart attacks and strokes that account for 36 percent of all deaths in the U.S. But few people know that boosting the body's levels of a single molecule of nitric oxide can help prevent, control, and even reverse cardiovascular disease.