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Author: U.s. Department of Health and Human Services Publisher: Createspace Independent Publishing Platform ISBN: 9781495287497 Category : Medical Languages : en Pages : 348
Book Description
This toxicological profile is prepared in accordance with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the toxic substances each profile describes. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicologic properties. Other pertinent literature is also presented but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The profiles focus on health and toxicologic information; therefore, each toxicological profile begins with a public health statement that describes, in nontechnical language, a substance's relevant toxicological properties. Following the public health statement is information concerning levels of significant human exposure and, where known, significant health effects. A health effects summary describes the adequacy of information to determine a substance's health effects. ATSDR identifies data needs that are significant to protection of public health. Each profile: (A) Examines, summarizes, and interprets available toxicologic information and epidemiologic evaluations on a toxic substance to ascertain the levels of significant human exposure for the substance and the associated acute, subacute, and chronic health effects; (B) Determines whether adequate information on the health effects of each substance is available or being developed to determine levels of exposure that present a significant risk to human health of acute, subacute, and chronic health effects; and (C) Where appropriate, identifies toxicologic testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans.
Author: U.s. Department of Health and Human Services Publisher: Createspace Independent Publishing Platform ISBN: 9781495287497 Category : Medical Languages : en Pages : 348
Book Description
This toxicological profile is prepared in accordance with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the toxic substances each profile describes. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicologic properties. Other pertinent literature is also presented but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The profiles focus on health and toxicologic information; therefore, each toxicological profile begins with a public health statement that describes, in nontechnical language, a substance's relevant toxicological properties. Following the public health statement is information concerning levels of significant human exposure and, where known, significant health effects. A health effects summary describes the adequacy of information to determine a substance's health effects. ATSDR identifies data needs that are significant to protection of public health. Each profile: (A) Examines, summarizes, and interprets available toxicologic information and epidemiologic evaluations on a toxic substance to ascertain the levels of significant human exposure for the substance and the associated acute, subacute, and chronic health effects; (B) Determines whether adequate information on the health effects of each substance is available or being developed to determine levels of exposure that present a significant risk to human health of acute, subacute, and chronic health effects; and (C) Where appropriate, identifies toxicologic testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309126479 Category : Business & Economics Languages : en Pages : 226
Book Description
It is the unique mission of the Health Hazard Evaluation Program within the National Institute for Occupational Safety and Health (NIOSH) to respond to requests to investigate potential occupational health hazards. In contrast to other NIOSH programs, the Health Hazard Evaluation Program is not primarily a research program. Rather, it investigates and provides advice to workplaces in response to requests from employers, employees and their representatives, and federal agencies. The National Research Council was charged with evaluating the NIOSH Health Hazard Evaluation Program and determining whether program activities resulted in improvements in workplace practices and decreases in hazardous exposures that cause occupational illnesses. The program was found to play a key role in addressing existing widespread or emerging occupational health issues. This book makes several recommendations that could improve a very strong program including more systematic use of surveillance data to facilitate priority setting, and greater interaction with a broader array of workers, industries, and other government agencies.
Author: Edward J. Calabrese Publisher: Wiley-Interscience ISBN: Category : Medical Languages : en Pages : 360
Book Description
A critical assessment of the animal models and human clinical and population-based studies that highlight the physiological and biochemical differences between male-female responses to toxic substances. Focuses on the organ systems that are especially sensitive to toxicants and pollutants. Investigates the extent to which the pregnant state may alter a susceptibility to toxic substances, with particular emphasis on alterations in drug metabolism. Shows the significance such findings have for regulatory agencies concerned with environmental health.
Author: Edward J. Calabrese Publisher: John Wiley & Sons ISBN: Category : Medical Languages : en Pages : 296
Book Description
1 INTRODUCTION. 2 DEVELOPMENTAL PROCESSES. 3 GENETIC DISORDERS. 4 NUTRITIONAL DEFICIENCIES AND SUPPLEMENTATION. 5 DISEASES AND POLLUTION EXPOSURE. 6 BEHAVIOR AND POLLUTANT EXPOSURE. 7 SCREENING TESTS FOR HYPERSUSCEPTIBILITY POPULATIONS WITH PARTICULAR REFERENCE TO WORKER EXPOSURE. 8 HIGH RISK GROUPS IN PERSPECTIVE. 9 PRACTICAL APPLICATIONS AND POLLUTANT PRIORITIES.
Author: Edward J. Calabrese Publisher: Wiley-Interscience ISBN: Category : Medical Languages : en Pages : 330
Book Description
Investigates the relationship between age and environmentally induced diseases, which must be taken into consideration in establishing acceptable exposure standards for high-risk groups in society. Assesses the effect of age on gastrointestinal and dermal absorption of toxic substances and drugs, and age differences in plasma protein binding and xenobiotic metabolism. Contains several chapters on organ-specific toxicity differences according to age. Also discusses genotoxicity and environmentally induced cancer. A final chapter synthesizes the information and addresses the relevance of this knowledge to biological basis of safety considerations.
Author: U.s. Department of Health and Human Services
Author: U.s. Department of Health and Human Services
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Author: Arthur L. Frank
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Author: Institute of Medicine
Author: Edward J. Calabrese
Author: Edward J. Calabrese
Author: Edward J. Calabrese