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Author: Francesk Mulita Publisher: Frontiers Media SA ISBN: 2832556027 Category : Medical Languages : en Pages : 220
Book Description
Colorectal disorders have come to the forefront of modern endoscopic and minimally invasive surgery due to the significant incidence rates and effects on patient quality of life (QoL). Heralded by the rising diagnosis rates of early-onset colorectal cancer, surgical techniques on resection, lymph node harvesting, and bowel anastomosis have been rapidly advancing, in parallel to more minimally invasive approaches such as stenting, tattooing and endoscopic resection. While the role of the colorectal specialist surgeon is central in treating benign and malignant colorectal disease, we must further study the role of novel biomarkers, tumor genomics and proteomics, as well as the use of less invasive methods with regards to the prognosis and outcomes of such patients.
Author: Francesk Mulita Publisher: Frontiers Media SA ISBN: 2832556027 Category : Medical Languages : en Pages : 220
Book Description
Colorectal disorders have come to the forefront of modern endoscopic and minimally invasive surgery due to the significant incidence rates and effects on patient quality of life (QoL). Heralded by the rising diagnosis rates of early-onset colorectal cancer, surgical techniques on resection, lymph node harvesting, and bowel anastomosis have been rapidly advancing, in parallel to more minimally invasive approaches such as stenting, tattooing and endoscopic resection. While the role of the colorectal specialist surgeon is central in treating benign and malignant colorectal disease, we must further study the role of novel biomarkers, tumor genomics and proteomics, as well as the use of less invasive methods with regards to the prognosis and outcomes of such patients.
Author: Massimo Pignatelli Publisher: JP Medical Ltd ISBN: 1907816852 Category : Medical Languages : en Pages : 192
Book Description
Part of the Recent Advnaces series, Histopathology is a collection of comprehensive reviews, with emphasis on breakthroughs and their practical relevance to clinical practice, providing essential reading to help clinicians and trainees remain up to date in the field.
Author: Kevin M. Haigis, Ph.D. Publisher: Springer Science & Business Media ISBN: 146148412X Category : Medical Languages : en Pages : 319
Book Description
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
Author: Stella Pelengaris Publisher: John Wiley & Sons ISBN: 1118430859 Category : Science Languages : en Pages : 632
Book Description
The Molecular Biology of Cancer, Stella Pelengaris & Michael Khan This capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. “Bench to Bedside”: A key strength of this book that sets it apart from general cancer biology references is the interweaving of all aspects of cancer biology from the causes, development and diagnosis through to the treatment and care of cancer patients – essential for providing a broader view of cancer and its impact. The highly readable presentation of a complex field, written by an international panel of researchers, specialists and practitioners, would provide an excellent text for graduate and undergraduate courses in the biology of cancer, medical students and qualified practitioners in the field preparing for higher exams, and for researchers and teachers in the field. For the teaching of cancer biology, special features have been included to facilitate this use: bullet points at the beginning of each chapter explaining key concepts and controversial areas; each chapter builds on concepts learned in previous chapters, with a list of key outstanding questions remaining in the field, suggestions for further reading, and questions for student review. All chapters contain text boxes that provide additional and relevant information. Key highlights are listed below: An overview of the cancer cell and important new concepts. Selected human cancers: lung, breast, colorectal, prostate, renal, skin, cervix, and hematological malignancies. Key cellular processes in cancer biology including (a) traditionally important areas such as cell cycle control, growth regulation, oncogenes and tumour suppressors apoptosis, as well as (b) more highly topical areas of apoptosis, telomeres, DNA damage and repair, cell adhesion, angiogenesis, immunity, epigenetics, and the proteasome. Clinical oncology: In-depth coverage of important concepts such as screening, risk of cancer and prevention, diagnoses, managing cancer patients from start to palliative care and end-of-life pathways. Chapters highlighting the direct links between cancer research and clinical applications. New coverage on how cancer drugs are actually used in specific cancer patients, and how therapies are developed and tested. Systems Biology and cutting edge research areas covered such as RNA interference (RNAi). Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review. Quotations have been used in each chapter to introduce basic concepts in an entertaining way. Supported by a dedicated website at www.blackwellpublishing.com/pelengaris We should list the great reviews we got for first edition which are on the back of the 2nd edition: “A capturing, comprehensive, clearly written and absolutely accurate introduction into cancer biology.....This book deserves great praise for the readable presentation of this complex field....the true synthesis of bench and bedside approaches is marvelously achieved.” Christian Schmidt, Molecular Cell “Chapters address the issues of cancer diagnosis, treatment, and patient care and set the book apart from general molecular biology references....This book is applicable to both graduate and undergraduate students, and in the context of a research laboratory, this book would be an excellent resource as a reference guide for scientists at all levels.” V.Emuss, Institute of Cancer Research, London. Also, from the first edition: “Pelengaris, Khan, and the contributing authors are to be applauded. The Molecular Biology of Cancer is a comprehensive and readable presentation of the many faces of cancer from molecular mechanisms to clinical therapies and diagnostics. This book will be welcomed by neophyte students, established scientists in other fields, and curious physicians.” -Dean Felsher, Stanford University
Author: Aldo Rocca Publisher: Frontiers Media SA ISBN: 2832556000 Category : Medical Languages : en Pages : 134
Book Description
March is Colorectal Cancer Awareness Month and at Frontiers in Oncology we want to highlight the recent discoveries in the field and raise awareness of the importance of early diagnosis, multidisciplinary management, and technological innovation support. Colorectal cancer (CRC) is the third most common cancer worldwide and represents one of the most relevant challenges for present and future global health, with 50 % of patients affected by CRC developing metastasis. Despite the introduction of novel therapeutic approaches and anticancer drugs, colorectal metastatic cancer (mCRC) continue to have a poor prognosis. In the last years, the extensive investigation on biomarkers that could identify patients at high risk for metastasis and predict the response to therapies has deeply impacted the therapeutic approaches to patients with mCRC. The most established biomarkers for mCRC are microsatellite instability (MSI) or mismatch repair deficiency (dMMR), HER2 amplification, RAS/BRAF mutations, and sidedness. Immune checkpoint inhibitors (ICIs) have been extensively used to treat patients with microsatellite unstable or mismatch repair-deficient (dMMR) CRC, while patients harboring a BRAFV600E mutation benefit from combination therapy with chemotherapy and immunotherapy drugs. The success of biomarker-driven patient selection to improve the therapeutic response and the overall survival of patients with mCRC highlights the imperative need for further research to identify novel biomarkers for better patient-tailored therapy.
Author: Giovanni Dapri Publisher: Springer ISBN: 443155579X Category : Medical Languages : en Pages : 597
Book Description
This book describes the various procedures, including surgery through the abdominal wall, through a transanal access or by the union of both, using an open, laparoscopic, or robotic approach. Worldwide pioneers for each technique are invited as authors and portray in step-by-step detail about each procedure. Of the 32 chapters, 23 are dedicated only for the surgical procedures. Each chapter is enriched by numerous figures, which complement the text, permitting the understanding of each surgical technique from its beginning until the last step. Eight additional chapters are dedicated to the clinical and anatomical aspects of rectal cancer. In the last decade there has been an impressive evolution in the treatment of patients with rectal cancer, with a focus not only on the preservation of a cancer-free life, but the quality of that life. This book has been written to be useful for everyone involved in rectal cancer management. From internists, gastroenterologists, endoscopists, oncologists, radiotherapists and radiologists involved in the treatment of rectal cancer during their daily practice, to surgeons specialized in colorectal surgery, to junior faculty to trainees, all interested in new and innovative techniques.
Author: Gloria Ravegnini Publisher: Frontiers Media SA ISBN: 2889662020 Category : Science Languages : en Pages : 78
Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author: Francesk Mulita
Author: Francesk Mulita
Author: Xuelei Ma
Author: Massimo Pignatelli
Author: Kevin M. Haigis, Ph.D.
Author: Catherine Alix-Panabieres
Author: Stella Pelengaris
Author: Aldo Rocca
Author: Tomoharu Sugie
Author: Giovanni Dapri
Author: Gloria Ravegnini