New Roles of Autophagy Pathways in Cancer PDF Download

Author: Daniel Hector Grasso
Publisher: Frontiers Media SA
ISBN: 2889712818
Category : Science
Languages : en
Pages : 369

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Book Description

Author: M. A. Hayat
Publisher: Academic Press
ISBN: 0128094273
Category : Medical
Languages : en
Pages : 431

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Book Description
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. - Presents the most advanced information regarding the role of the autophagic system in life and death - Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both - Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation - Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment - Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Author: Patrizia Agostinis
Publisher: Frontiers Media SA
ISBN: 2889454223
Category :
Languages : en
Pages : 111

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Book Description
Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of autophagy during tumor development and dissemination. The discoveries that autophagy may either support or repress neoplastic growth and contextually favor or weaken resistance and impact antitumor immunity have spurred efforts from many laboratories trying to conceptualize the complex role of autophagy in cancer using cellular and preclinical models. This complexity is further accentuated by recent findings highlighting that various autophagy-related genes have roles beyond this catabolic mechanism and interface with oncogenic pathways, other trafficking and degradation mechanisms and the cell death machinery. From a therapeutic perspective, knowledge of how autophagy modulates the tumor microenvironment is crucial to devise autophagy-targeting strategies using smart combination of drugs or anticancer modalities. This eBook contains a collection of reviews by autophagy researchers and provides a background to the state-of-the-art in the field of autophagy in cancer, focusing on various aspects of autophagy regulation ranging from its molecular components to its cell autonomous role, e.g. in cell division and oncogenesis, miRNAs regulation, cross-talk with cell death pathways as well as cell non-autonomous role, e.g. in secretion, interface with tumor stroma and clinical prospects of autophagy-based biomarkers and autophagy modulators in anticancer therapy. This eBook is part of the TransAutophagy initiative to better understand the clinical implications of autophagy in cancer.

Author: Hong-Gang Wang
Publisher: Springer Science & Business Media
ISBN: 1461465613
Category : Medical
Languages : en
Pages : 267

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Book Description
With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it. ​

Author: Noemí Rubio Romero
Publisher: Elsevier Inc. Chapters
ISBN: 0128069171
Category : Medical
Languages : en
Pages : 34

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Book Description
Reactive oxygen species (ROS) have emerged as signaling molecules in pathways regulating cell growth and differentiation, inflammation, immune responses, survival, and death. ROS have been shown to promote autophagy, a lysosomal pathway for degradation of dysfunctional unnecessary cellular components. In fact, recent works have revealed a complex cross-talk between these intertwined signals. Whereas ROS can modulate autophagy activation in response to different types of stimuli, autophagy, in turn, may modulate ROS production by degrading, for example, dysfunctional mitochondria that generate aberrant amounts of ROS. Autophagy pathways can act both as tumor-promoter and tumor-suppressor mechanisms, with involvement of ROS in both cases. Paradoxically, whereas ROS and autophagy regulation may contribute to cancer initiation and progression, many antineoplastic treatments are precisely based on the massive production of ROS and activation of autophagy to induce cell death and eradication of diseased tissue. Nevertheless, autophagy activation has also shown a cytoprotective role against the efficiency of the therapy, and the mechanism that controls the switch between these two cellular functions in still unknown. In this chapter we will review the molecular mechanisms by which ROS modulate autophagy, and those modulated by autophagy to control ROS production, in the context both of cancer development and of cancer treatment.

Author: M. A. Hayat
Publisher: Academic Press
ISBN: 0128010541
Category : Medical
Languages : en
Pages : 339

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Book Description
Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 5 comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. In spite of the increasing importance of autophagy in the various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases remains poorly understood. This book is an asset to newcomers as a concise overview of the diverse disease implications of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series

Author: Salem Chouaib
Publisher: Academic Press
ISBN: 0128227575
Category : Science
Languages : en
Pages : 244

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Book Description
Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies. - Presents updated knowledge on autophagy at the basic level and its potential use in cancer treatment - Offers the first book to cover autophagy at the interface of cell biology, immunology and tumor biology - Provides a wealth of information on the topic in a coherent and comprehensive collection of contributions by world renowned scientists and investigators

Author: Yannick Bailly
Publisher: BoD – Books on Demand
ISBN: 9535110624
Category : Science
Languages : en
Pages : 526

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Book Description
The chapters in this book review the latest advances in the molecular mechanisms of autophagy, highlighting some of the most challenging research topics. The focus is mainly on how this basic cell defense mechanism comes into play in various pathologies, including liver diseases, myopathies, infectious diseases, cancers and neurodegenerative diseases. In these diseases, the contradictory autophagy roles of cell survival versus cell death emphasize the necessity of taking into account this double-edged nature in future development of already promising, autophagy- modulating, therapies.

Author:
Publisher: Academic Press
ISBN: 0128241594
Category : Medical
Languages : en
Pages : 384

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Book Description
Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. Addresses the relationship between autophagy and senescence in cancer therapy Covers autophagy and senescence in tumor dormancy Explores autophagy and senescence in disease recurrence

Author: Sujit Kumar Bhutia
Publisher: Springer Nature
ISBN: 9811569304
Category : Medical
Languages : en
Pages : 284

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Book Description
This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.