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Author: Enrico Chiavazza Publisher: LAP Lambert Academic Publishing ISBN: 9783659416200 Category : Languages : en Pages : 132
Book Description
Nowadays, imaging techniques are an indispensable tool in cancer research, clinical trials and medical practice and they are of great aid for oncologists to localize and characterize abnormal tissues. Detection and characterization of lesions, especially tumors, can be achieved by using specific tracers or contrast media that are capable of selectively interact with the biological target. This approach is defined as Molecular Imaging. A MI probe is usually composed of a biologically active component (vector) that interacts with the intended molecular target, an imaging reporter that should produce a detectable signal and a linker between the two components. Among the different imaging modalities only a few are characterized by the merging of these functional units into one molecular identity: PET tracers and Hyperpolarized MRI probes use labeled nuclides (either radioactive or stable) as imaging reporters within the biologically active molecule. My work has dealt with the development of hyperpolarized MRI tracers, which are able to overcome the sensitivity issue typical of the MRI methodology avoiding the radiological concerns that negatively affect the use of nuclear techniques.
Author: Enrico Chiavazza Publisher: LAP Lambert Academic Publishing ISBN: 9783659416200 Category : Languages : en Pages : 132
Book Description
Nowadays, imaging techniques are an indispensable tool in cancer research, clinical trials and medical practice and they are of great aid for oncologists to localize and characterize abnormal tissues. Detection and characterization of lesions, especially tumors, can be achieved by using specific tracers or contrast media that are capable of selectively interact with the biological target. This approach is defined as Molecular Imaging. A MI probe is usually composed of a biologically active component (vector) that interacts with the intended molecular target, an imaging reporter that should produce a detectable signal and a linker between the two components. Among the different imaging modalities only a few are characterized by the merging of these functional units into one molecular identity: PET tracers and Hyperpolarized MRI probes use labeled nuclides (either radioactive or stable) as imaging reporters within the biologically active molecule. My work has dealt with the development of hyperpolarized MRI tracers, which are able to overcome the sensitivity issue typical of the MRI methodology avoiding the radiological concerns that negatively affect the use of nuclear techniques.
Author: Xiaoyuan Chen Publisher: World Scientific ISBN: 9814293679 Category : Medical Languages : en Pages : 1102
Book Description
This review volume integrates the advances in cancer biology, molecular imaging techniques and imaging probes for visualization and quantitative measurement of anatomical, functional, and molecular profiles of cancer. The volume also presents a comprehensive summary of the state-of-the-art technology in molecular imaging probe design and applications in radionuclide (PET and SPECT), magnetic resonance (MR), optical (fluorescence, Raman, photoacoustic), ultrasound, CT, and multimodality imaging. Bringing together the fundamentals of molecular imaging, and the basic principles of each molecular imaging modality in this volume, readers' understanding in this field is further enhanced. With a strong emphasis on the chemistry of the design of appropriate molecular imaging probes for early cancer detection, therapy-response monitoring, and anti-cancer drug development, the process of translating novel cancer imaging probes from bench to bedside is extensively discussed.
Author: Michael J. Welch Publisher: CRC Press ISBN: 1439841950 Category : Science Languages : en Pages : 390
Book Description
Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.
Author: Stefan Kubik Publisher: John Wiley & Sons ISBN: 3527344675 Category : Science Languages : en Pages : 586
Book Description
Provides deep insight into the concepts and recent developments in the area of supramolecular chemistry in water Written by experts in their respective field, this comprehensive reference covers various aspects of supramolecular chemistry in water?from fundamental aspects to applications. It provides readers with a basic introduction to the current understanding of the properties of water and how they influence molecular recognition, and examines the different receptor types available in water and the types of substrates that can be bound. It also looks at areas to where they can be applied, such as materials, optical sensing, medicinal imaging, and catalysis. Supramolecular Chemistry in Water offers five major sections that address important topics like water properties, molecular recognition, association and aggregation phenomena, optical detection and imaging, and supramolecular catalysis. It covers chemistry and physical chemistry of water; water-mediated molecular recognition; peptide and protein receptors; nucleotide receptors; carbohydrate receptors; and ion receptors. The book also teaches readers all about coordination compounds; self-assembled polymers and gels; foldamers; vesicles and micelles; and surface-modified nanoparticles. In addition, it provides in-depth information on indicators and optical probes, as well as probes for medical imaging. -Covers, in a timely manner, an emerging area in chemistry that is growing more important every day -Addresses topics such as molecular recognition, aggregation, catalysis, and more -Offers comprehensive coverage of everything from fundamental aspects of supramolecular chemistry in water to its applications -Edited by one of the leading international scientists in the field Supramolecular Chemistry in Water is a one-stop-resource for all polymer chemists, catalytic chemists, biochemists, water chemists, and physical chemists involved in this growing area of research.
Author: Lorenzo Tei Publisher: Frontiers Media SA ISBN: 288945598X Category : Languages : en Pages : 129
Book Description
Over the past decades, the field of molecular imaging has been rapidly growing involving multiple disciplines such as medicine, biology, chemistry, pharmacology and biomedical engineering. Any molecular imaging procedure requires an imaging probe that is an agent used to visualize, characterize and quantify biological processes in living systems. Such a probe typically consists of an agent that usually produces signal for imaging purpose, a targeting moiety, and a linker connecting the targeting moiety and the signaling agent. Many challenging problems of molecular imaging can be addressed by exploiting the great possibilities offered by modern synthetic organic and coordination chemistry and the powerful procedures provided by conjugation chemistry. Thus, chemistry plays a decisive role in the development of this cutting-edge methodology. Currently, the diagnostic imaging modalities include Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Ultrasound (US), Nuclear Imaging (PET, SPECT), Optical Imaging (OI) and Photoacoustic Imaging (PAI). Each of these imaging modalities has its own advantages and disadvantages, and therefore, a multimodal approach combining two techniques is often adopted to generate complementary anatomical and functional information of the disease. The basis for designing imaging probes for a given application is dictated by the chosen imaging modality, which in turn is dependent upon the concentration and localization profile (vascular, extracellular matrix, cell membrane, intracellular, near or at the cell nucleus) of the target molecule. The development of high-affinity ligands and their conjugation to the targeting vector is also one of the key steps for pursuing efficient molecular imaging probes. Other excellent reviews, text and monographs describe the principles of biomedical imaging, focusing on molecular biology or on the physics behind the techniques. This Research Topic aims to show how chemistry can offer molecular imaging the opportunity to express all its potential.
Author: Alexei Bogdanov Publisher: Springer Science & Business Media ISBN: 354026809X Category : Medical Languages : en Pages : 269
Book Description
The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.
Author: Otmar Schober Publisher: Springer Science & Business Media ISBN: 3642108539 Category : Medical Languages : en Pages : 421
Book Description
The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing steadily. Many innovative molecular imaging probes have already entered clinical practice, and there is no doubt that the future emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation. This handbook addresses all aspects of molecular imaging in oncology, from basic research to clinical applications. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.
Author: Wellington Pham Publisher: Springer Nature ISBN: 9811957398 Category : Technology & Engineering Languages : en Pages : 321
Book Description
This book describes insight mechanisms for designing molecular probes and methods that these agents can be used for medical diagnosis in preclinical animal models via optical, MRI and PET imaging. The book has a wealth of schemes of synthesis and methods deduced from pioneers in the field, making it possible to immerse into real-world molecular imaging. Written for graduate student training and practitioners, this book will serve as a teaching material and/or reference for anyone interested in exploring the power of chemical synthesis of imaging agents.
Author: Otmar Schober Publisher: Springer ISBN: 9783642108549 Category : Medical Languages : en Pages : 416
Book Description
The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing steadily. Many innovative molecular imaging probes have already entered clinical practice, and there is no doubt that the future emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation. This handbook addresses all aspects of molecular imaging in oncology, from basic research to clinical applications. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.
Author: Enrico Chiavazza
Author: Enrico Chiavazza
Author: Xiaoyuan Chen
Author: Michael J. Welch
Author: Stefan Kubik
Author: Lorenzo Tei
Author: Alexei Bogdanov
Author: Otmar Schober
Author: Louise Tear
Author: Wellington Pham
Author: Otmar Schober