New Insights Into Understanding and Managing NAFLD PDF Download

Author: Águeda González Rodríguez
Publisher: Frontiers Media SA
ISBN: 288971988X
Category : Medical
Languages : en
Pages : 223

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Book Description

Author: Naim Alkhouri
Publisher: CRC Press
ISBN: 1000928667
Category : Medical
Languages : en
Pages : 556

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Book Description
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity and metabolic syndrome epidemics, which this up-to-date book deals with comprehensively. The contents outline disease mechanisms, diagnostic tests, management, varying manifestations, and special populations. It covers the mechanistic pathways that contribute to NAFLD development, including the role of genetic variants and the gut microbiome. It elaborates on noninvasive diagnostic tests to screen for NAFLD, determine its severity, and monitor response to lifestyle intervention and pharmacologic treatment. This book helps clinicians diagnose and treat this common and potentially deadly disease. Key Features: Reviews current drugs in development and provides practical advice to clinicians on the diagnosis and management of fatty liver. Proves attractive to primary care providers who are on the front line of managing patients with NAFLD, to gastroenterologists and hepatologists who would benefit from updated data on how to risk-stratify patients and identify those who will be eligible for pharmacologic treatment, and other specialists such as cardiologists, endocrinologists, and nephrologists who will find this book to be a useful reference on the extrahepatic manifestations of NAFLD. Focuses on extrahepatic manifestations and new insights on the mechanistic drivers of the disease.

Author:
Publisher: ScholarlyEditions
ISBN: 1464974330
Category : Medical
Languages : en
Pages : 63

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Book Description
Fatty Liver: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Fatty Liver in a concise format. The editors have built Fatty Liver: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Fatty Liver in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Fatty Liver: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author: Ramón Anibal Rodrigo Salinas
Publisher: Nova Science Publishers
ISBN: 9781634842174
Category : Fatty liver
Languages : en
Pages : 0

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Book Description
Non-alcoholic fatty liver disease, or NAFLD, represents a spectrum of pathologic liver histologic findings ranging from the simple accumulation of fat, known as steatosis, to nonalcoholic steatohepatitis and cirrhosis. It is estimated that NAFLD in all of its forms would have a 20% prevalence worldwide, but the evidence suggests a higher rate for developed countries, exceeding 30% for the US general population. Major risk factors for NAFLD, such as ageing, obesity and insulin resistance, are projected to increase in the following decades, causing the prevalence and relevance of NAFLD to rise in the future. In obese populations and type 2 diabetes patients, the prevalence of this disease exceeds 70%. NAFLD has been called the "silent epidemic" for its lack of symptoms, relatively complex diagnosis and its deleterious effects. The association between NAFLD with cardiovascular diseases, energy metabolism disorders and polycystic ovarian syndrome has promoted the inclusion of this liver pathology within the metabolic syndrome. From a biochemical point of view, current evidence suggests the existence of a bidirectional causal relationship between NAFLD and oxidative stress, where various alterations energy metabolism and important inflammatory components are involved. An abnormal glucose and fatty acid metabolism lead to glucotoxicity and lipotoxicity, respectively, which promote oxidative stress through different pathways. Oxidative stress induces the expression of pro-inflammatory mediators, including transcription factors and cytokines, which trigger an immune activation, a key step in the transition from simple steatosis to steatohepatitis. An early diagnosis and optimal therapy are essential for NAFLD treatment. First-line treatment of NAFLD focuses on lifestyle changes. Weight reduction through an increase in physical activity and/or nutritional management is considered safe and effective, but pharmacological management of common comorbidities such as hyperglycemia, dyslipidemias and hypertension are also essential. The key role of oxidative stress in NAFLD pathophysiology suggests that antioxidant interventions based in natural substances such as polyphenols would be effective. Recently, it was shown that the antioxidant properties of these compounds are beyond their free radical scavenging. This book presents an update of research advances contributing to a better understanding of relevant clinical models of NAFLD, particularly, the disorder in energy metabolism and the role of oxidative stress. It also highlights the clinical and pathophysiological association between NAFLD and the metabolic syndrome, and presents an overview of current diagnosis and treatment and the future avenues for the management of this disease.

Author:
Publisher: ScholarlyEditions
ISBN: 1464977801
Category : Medical
Languages : en
Pages : 37

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Book Description
Alcoholic Fatty Liver: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Alcoholic Fatty Liver in a compact format. The editors have built Alcoholic Fatty Liver: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Alcoholic Fatty Liver in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Alcoholic Fatty Liver: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author: Ju-Seop Kang
Publisher: Intechopen
ISBN: 9781839680908
Category :
Languages : en
Pages : 0

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Book Description
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis that develops in the absence of competing for liver disease etiologies such as alcohol consumption, monogenic hereditary conditions, or iatrogenic causes. The pathogenesis of NAFLD is multifactorial and its understanding is still incomplete. Although knowledge of the cellular and molecular mechanisms underlying disease development and progression has grown significantly in recent years, the exact contribution of environmental and genetic factors as well as that of extrahepatic and intrahepatic events in determining the disease phenotype remains ill defined. This book discusses topics highly correlated with NAFLD such as the regulation of iron metabolism, the role of the enzyme heparanase in liver steatosis, transcriptional regulation by ERR and its role in pathogenesis, hepatic lipid homeostasis, therapeutic approaches to NAFLD, and pathogenesis and significance of HDL as a molecular modifier in NAFLD.

Author: Ns. Arif Rohman Mansur, S.Kep., M.Kep
Publisher: PENERBIT KBM INDONESIA
ISBN: 6234998968
Category : Antiques & Collectibles
Languages : en
Pages : 191

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Book Description
In The Unseen Battle: Living with Non-Alcoholic Fatty Liver Disease (NAFLD) Ns. Arif Rohman Mansur, S.Kep. M.Kep, offers an in-depth exploration of a silent yet widespread liver condition affecting millions globally. This comprehensive guide begins with an overview of the liver’s essential functions, laying the groundwork for a detailed examination of NAFLD, its causes, risk factors, and the disease’s progression. The book is meticulously structured, starting with the fundamentals of liver anatomy and physiology, then delving into the liver’s metabolic roles, including carbohydrate, fat, and protein metabolism. It transitions to an exhaustive analysis of NAFLD, covering its definition, prevalence, and significant health concerns. The author elucidates the multifaceted causes and risk factors, such as genetic predispositions, lifestyle choices, and environmental influences, offering a clear understanding of how these elements exacerbate liver conditions. A notable section is dedicated to the symptoms of NAFLD, emphasizing how the disease often remains unnoticed in its early stages, only manifesting severe symptoms like jaundice, pruritis, and ascites as it progresses. Diagnostic approaches are thoroughly examined, from clinical evaluations and laboratory tests to advanced imaging studies and liver biopsies. The book extends beyond diagnosis, providing valuable insights into lifestyle changes essential for managing NAFLD. It discusses dietary modifications, weight loss strategies, and the importance of physical activity, all supported by scientific evidence and practical tips. Additionally, the book explores pharmacological treatments, including the latest research on medications that can help manage and potentially reverse the condition. The Unseen Battle serves as both a health reference and a beacon of hope, encouraging readers to take control of their health through informed decisions and lifestyle changes. This book is an essential read for anyone affected by or interested in understanding non-alcoholic fatty liver disease.

Author:
Publisher: ScholarlyEditions
ISBN: 1481658743
Category : Medical
Languages : en
Pages : 109

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Book Description
Fatty Liver: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Diagnosis and Screening in a concise format. The editors have built Fatty Liver: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Fatty Liver: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author: Geoffrey C. Farrell
Publisher: John Wiley & Sons
ISBN: 1118556224
Category : Medical
Languages : en
Pages : 438

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Book Description
The sharp rise in cases of Non-alcoholic fatty liver disease is fast becoming one of the major concerns for hepatologists worldwide. This comprehensive clinical guide explains how to diagnose NAFLD and manage patients according to the best standards of care. Contributors from the world's leading institutions concentrate on patient care, drawing on their extensive experience.

Author: Dr Rundell Meehan
Publisher: Independently Published
ISBN:
Category : Health & Fitness
Languages : en
Pages : 0

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Book Description
Are you tired of feeling helpless in the face of Non-Alcoholic Fatty Liver Disease (NAFLD)? Do you want to take charge of your liver health and break free from the crisis it brings? Look no further! "Breaking the Crisis on Non-Alcoholic Fatty Liver Disease" is your ultimate guide to understanding, managing, and conquering NAFLD. In this groundbreaking book, you'll embark on a journey through the intricate landscape of NAFLD, starting with a deep dive into its origins, prevalence, and global impact. From unraveling the mystery of NAFLD to exploring its various stages, complications, and comorbidities, every chapter is a revelation. Delve into the anatomy of the liver and grasp its pivotal role in NAFLD development. Learn about the spectrum of NAFLD, from simple steatosis to the advanced stages fraught with complications like hepatocellular carcinoma and heart problems. But fear not, as this book arms you with the knowledge and techniques needed to intervene and supervise your liver health effectively. Discover the myriad risk factors and contributors to NAFLD, from genetics to metabolic syndrome, insulin resistance, and diabetes. Equip yourself with the tools for diagnosis and screening, including clinical evaluation, imaging techniques, and laboratory tests, ensuring early detection and proactive management. But knowledge alone is not enough; actionable steps are crucial. Learn how lifestyle modifications, dietary strategies, physical activity, and weight management can significantly impact NAFLD progression. Explore pharmacological interventions and emerging therapies, alongside the challenges and future developments in treatment options. As you journey through the pages, gain invaluable insights into the comorbidities associated with NAFLD, understanding its cardiovascular implications, type 2 diabetes connection, and impact on overall health. Walk alongside patients as they share their perspectives, coping strategies, and support networks, offering invaluable wisdom and solidarity. Moreover, "Breaking the Crisis on Non-Alcoholic Fatty Liver Disease" doesn't stop at individual health; it extends to prevention and public health initiatives. Dive into discussions on public awareness, education, policy implications, and future directions in NAFLD prevention, advocating for systemic change and collective action. This book is not just a passive read; it's a call to action-a roadmap to reclaiming your liver health and transforming your life. Don't let NAFLD dictate your future; empower yourself with knowledge, strategies, and a commitment to wellness. Your liver deserves nothing less. Take the first step towards a healthier tomorrow-GRAB YOUR COPY of "Breaking the Crisis on Non-Alcoholic Fatty Liver Disease" now and embark on a journey of healing, resilience, and triumph.