New Frontiers and Applications of Synthetic Biology PDF Download

Author: Vijai Singh
Publisher: Academic Press
ISBN: 0323859860
Category : Science
Languages : en
Pages : 487

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Book Description
New Frontiers and Applications of Synthetic Biology presents a collection of chapters from eminent synthetic biologists across the globe who have established experience and expertise working with synthetic biology. This book offers several important areas of synthetic biology which allow us to read and understand easily. It covers the introduction of synthetic biology and design of promoter, new DNA synthesis and sequencing technology, genome assembly, minimal cells, small synthetic RNA, directed evolution, protein engineering, computational tools, de novo synthesis, phage engineering, a sensor for microorganisms, next-generation diagnostic tools, CRISPR-Cas systems, and more. This book is a good source for not only researchers in designing synthetic biology, but also for researchers, students, synthetic biologists, metabolic engineers, genome engineers, clinicians, industrialists, stakeholders and policymakers interested in harnessing the potential of synthetic biology in many areas. - Offers basic understanding and knowledge in several aspects of synthetic biology - Covers state-of-the-art tools and technologies of synthetic biology, including promoter design, DNA synthesis, DNA sequencing, genome design, directed evolution, protein engineering, computational tools, phage design, CRISPR-Cas systems, and more - Discusses the applications of synthetic biology for smart drugs, vaccines, therapeutics, drug discovery, self-assembled materials, cell free systems, microfluidics, and more

Author: Mark E. Bunnage
Publisher: Royal Society of Chemistry
ISBN: 184973125X
Category : Medical
Languages : en
Pages : 329

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Book Description
This book highlights the new frontiers in chemical biology and describes their impact and future potential in drug discovery.

Author: Rebecca Thombre
Publisher: Elsevier
ISBN: 0323859275
Category : Science
Languages : en
Pages : 340

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Book Description
New Frontiers in Astrobiology presents a simple and concise overview of the emerging field of astrobiology. Astrobiology studies the evolution, origin, and future of life on Earth and beyond. This book provides a brief overview of the current research and future status of this fascinating field. The book covers a wide range of topics from the history of astrobiology, the big bang, prebiotic chemistry, theories of the origin of life, extreme environments on Earth, and the quest for intelligent life in space. Currently, there is a critical gap in knowledge related to the future scope of astrobiology and its applications in science and society. The hallmark of the book is that it takes critical perspectives to analyze the new frontiers in astrobiology post Mars 2020/ExoMars missions that encompass the latestdevelopments in the detection of biosignatures and habitability beyond our Solar System (exomoons, exoplanets). The book will be a valuable resource for students, researchers, and scientists who seek greater insights into understanding the current status and future of astrobiology. - Explores the background and historical developments in astrobiology - Provides concise cutting-edge reviews on fundamental questions on origin and distribution of life on Earth, habitability beyond Earth, and future of life on Earth - Integrates contemporary and critical views in new frontiers in astrobiology

Author: Serge Morand
Publisher: Springer Science & Business Media
ISBN: 9400721145
Category : Medical
Languages : en
Pages : 335

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Book Description
Molecular epidemiology has recently broaden its focuses due to the development of molecular tools but also by incorporating advances of other fields such as mathematical epidemiology, molecular ecology, population genetics and evolution. Facing new risks of emerging and re-emerging infectious diseases that are threats for humans and their livestock, the objectives of molecular epidemiology include: - the development of molecular tools, genotyping and gene expression - the incorporation of concepts and results of population genetics of infectious diseases - the integration of recent advances in theoretical epidemiology and evolutionary ecology of diseases - a better understanding of transmission for the development of risk factors analyses. This book will demonstrate how the latest developments in molecular tools and in epidemiology can be integrated with studies of host-pathogen interactions. Besides a strong theoretical component, there will also be an emphasis on applications in the fields of epidemiology, public health, veterinary medicine, and health ecology. Students and researchers in the fields of epidemiology, animal and human health, evolutionary ecology, parasitology are the main potential readers of the book, as well as a broader audience from veterinary medicine and conservation.

Author: Heide Schatten
Publisher: Springer
ISBN: 3319956930
Category : Science
Languages : en
Pages : 135

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Book Description
This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.

Author: Colin Kleanthous
Publisher: Frontiers in Molecular Biology
ISBN: 9780199637607
Category : Carrier proteins
Languages : en
Pages : 370

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Book Description
The purpose of Protein-Protein Recognition is to bring together concepts and systems pertaining to protein-protein interactions in a single unifying volume. In the light of the information from the genome sequencing projects and the increase in structural information it is an opportune time totry to make generalizations about how and why proteins form complexes with each other. The emphasis of the book is on heteromeric complexes (complexes in which each of the components can exist in an unbound state) and will use well-studied model systems to explain the processes of formingcomplexes. After an introductory section on the kinetics, thermodynamics, analysis, and classification of protein-protein interactions, weak, intermediate, and high affinity complexes are dealt with in turn. Weak affinity complexes are represented by electron transfer proteins and integrincomplexes. Anti-lysozyme antibodies, the MHC proteins and their interactions with T-cell receptors, and the protein interactions of eukaryotic signal transduction are the systems used to explain complexes with intermediate affinities. Finally, tight binding complexes are represented by theinteraction of protein inhibitors with serine proteases and by nuclease inhibitor complexes. Throughout the chapters common themes are the technologies which have had the greatest impact, how specificity is determined, how complexes are stabilized, and medical and industrial applications.

Author: Dierk Scheel
Publisher: Oxford University Press, USA
ISBN: 9780199638802
Category : Science
Languages : en
Pages : 324

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Book Description
The growth and differentiation of living organisms are continuously adjusted to a multitude of environmental factors, each of which underlies a perpetual variation. The sessile existence of plants further emphasizes the requirement for efficient adaptation and defence mechanisms. The changes in environmental factors may range from moderate to dramatic and can concern many components at the same time. They may be abiotic or biotic in nature and range from essential to toxic in their effects. Among the numerous abiotic factors are nutrients, light, oxygen, water, temperature, gravity, wind, touch and chemicals. Biotic factors are represented by other organisms involved in symbiotic, pathogenic or herbivorous interactions with plants. All of these environmental factors are independently and specifically recognized by plants. Perception and overall response are linked by signal transduction pathways at cellular, systemic and interorganismic levels. In order to guarantee proper adaptation to the environment, signals generated following perception of a multitude of environmental factors need to be integrated and evaluated according to their importance. Cross-talk between different signaling pathways within such networks appears to be the basis for the evaluation of the importance of incoming signals. Knowledge of these complex processes allows a better understanding of the molecular mechanisms underlying adaptation. Modulation of distinct signaling elements can generate plants with improved stress resistance. This book represents a comprehensive summary of the enormous amount of information that is now available on signal transduction processes involved in the communication of plants with abiotic and biotic elements of their environment.

Author: Jianfeng Feng
Publisher: Springer Science & Business Media
ISBN: 1849961964
Category : Science
Languages : en
Pages : 411

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Book Description
Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician’s fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such as the International HapMap project, enable large-scale studies, such as genome-wide association st- ies, which could potentially identify most common genetic variants as well as rare variants of the human DNA that may alter individual’s susceptibility to disease and the response to medical treatment. Meanwhile the multi-electrode recording from behaving animals makes it feasible to control the animal mental activity, which could potentially lead to the development of useful brain–machine interfaces. - bracing the sheer volume of genetic, genomic, and other type of data, an essential approach is, ?rst of all, to avoid drowning the true signal in the data. It has been witnessed that theoretical approach to biology has emerged as a powerful and st- ulating research paradigm in biological studies, which in turn leads to a new - search paradigm in mathematics, physics, and computer science and moves forward with the interplays among experimental studies and outcomes, simulation studies, and theoretical investigations.

Author: Jaan Laane
Publisher: Elsevier
ISBN: 0128112212
Category : Science
Languages : en
Pages : 788

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Book Description
Frontiers and Advances in Molecular Spectroscopy once again brings together the most eminent scientists from around the world to describe their work at the cutting-edge of molecular spectroscopy. Much of what we know about atoms, molecules and the nature of matter has been obtained using spectroscopy over the last one hundred years or so. Going far beyond the topics discussed in Jaan Laane's earlier book on the subject, these chapters describe new methodologies and applications, instrumental developments and theory, which are taking spectroscopy into still new frontiers. The robust range of topics once again demonstrates the wide utility of spectroscopic techniques. New topics include ultrafast spectroscopy of the transition state, SERS/far-uv spectroscopy, femtosecond coherent anti-Stokes Raman spectroscopy, high-resolution laser induced fluorescence spectroscopy, Raman spectroscopy and biosensors, vibrational optical activity, ultrafast two-dimensional spectroscopy, biology with x-ray lasers, isomerization dynamics and hydrogen bonding, single molecule imaging, spectra of intermediates, matrix isolation spectroscopy and more. - Covers spectroscopic investigations on the cutting edge of science - Written and edited by leading experts in their respective fields - Allows researchers to access a broad range of essential modern spectroscopy content from a single source rather than wading through hundreds of scattered journal articles

Author: Avi Ma'ayan
Publisher: Springer Science & Business Media
ISBN: 9400743300
Category : Medical
Languages : en
Pages : 204

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Book Description
The rapidly developing field of systems biology is influencing many aspects of biological research and is expected to transform biomedicine. Some emerging offshoots and specialized branches in systems biology are receiving particular attention and are becoming highly active areas of research. This collection of invited reviews describes some of the latest cutting-edge experimental and computational advances in these emerging sub-fields of systems biology. In particular, this collection focuses on the study of mammalian embryonic stem cells; new technologies involving mass-spectrometry proteomics; single cell measurements; methods for modeling complex stochastic systems; network-based classification algorithms; and the revolutionary emerging field of systems pharmacology.