Multiple Testing Problems in Pharmaceutical Statistics PDF Download

Author: Alex Dmitrienko
Publisher: CRC Press
ISBN: 1584889853
Category : Mathematics
Languages : en
Pages : 323

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Book Description
Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c

Author: John C. Reinard
Publisher: SAGE Publications
ISBN: 1506320481
Category : Language Arts & Disciplines
Languages : en
Pages : 604

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Book Description
"While most books on statistics seem to be written as though targeting other statistics professors, John Reinard′s Communication Research Statistics is especially impressive because it is clearly intended for the student reader, filled with unusually clear explanations and with illustrations on the use of SPSS. I enjoyed reading this lucid, student-friendly book and expect students will benefit enormously from its content and presentation. Well done!" --John C. Pollock, The College of New Jersey Written in an accessible style using straightforward and direct language, Communication Research Statistics guides students through the statistics actually used in most empirical research undertaken in communication studies. This introductory textbook is the only work in communication that includes details on statistical analysis of data with a full set of data analysis instructions based on SPSS 12 and Excel XP. Key Features: Emphasizes basic and introductory statistical thinking: The basic needs of novice researchers and students are addressed, while underscoring the foundational elements of statistical analyses in research. Students learn how statistics are used to provide evidence for research arguments and how to evaluate such evidence for themselves. Prepares students to use statistics: Students are encouraged to use statistics as they encounter and evaluate quantitative research. The book details how statistics can be understood by developing actual skills to carry out rudimentary work. Examples are drawn from mass communication, speech communication, and communication disorders. Incorporates SPSS 12 and Excel: A distinguishing feature is the inclusion of coverage of data analysis by use of SPSS 12 and by Excel. Information on the use of major computer software is designed to let students use such tools immediately. Companion Web Site! A dedicated Web site includes a glossary, data sets, chapter summaries, additional readings, links to other useful sites, selected "calculators" for computation of related statistics, additional macros for selected statistics using Excel and SPSS, and extra chapters on multiple discriminant analysis and loglinear analysis. Intended Audience: Ideal for undergraduate and graduate courses in Communication Research Statistics or Methods; also relevant for many Research Methods courses across the social sciences

Author: Frank Bretz
Publisher: CRC Press
ISBN: 1420010905
Category : Mathematics
Languages : en
Pages : 202

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Book Description
Adopting a unifying theme based on maximum statistics, Multiple Comparisons Using R describes the common underlying theory of multiple comparison procedures through numerous examples. It also presents a detailed description of available software implementations in R. The R packages and source code for the analyses are available at http://CRAN.R-project.org After giving examples of multiplicity problems, the book covers general concepts and basic multiple comparisons procedures, including the Bonferroni method and Simes’ test. It then shows how to perform parametric multiple comparisons in standard linear models and general parametric models. It also introduces the multcomp package in R, which offers a convenient interface to perform multiple comparisons in a general context. Following this theoretical framework, the book explores applications involving the Dunnett test, Tukey’s all pairwise comparisons, and general multiple contrast tests for standard regression models, mixed-effects models, and parametric survival models. The last chapter reviews other multiple comparison procedures, such as resampling-based procedures, methods for group sequential or adaptive designs, and the combination of multiple comparison procedures with modeling techniques. Controlling multiplicity in experiments ensures better decision making and safeguards against false claims. A self-contained introduction to multiple comparison procedures, this book offers strategies for constructing the procedures and illustrates the framework for multiple hypotheses testing in general parametric models. It is suitable for readers with R experience but limited knowledge of multiple comparison procedures and vice versa. See Dr. Bretz discuss the book.

Author: Dongseok Choi
Publisher: Springer
ISBN: 9811081689
Category : Mathematics
Languages : en
Pages : 168

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Book Description
This book presents the proceedings of the 2nd Pacific Rim Statistical Conference for Production Engineering: Production Engineering, Big Data and Statistics, which took place at Seoul National University in Seoul, Korea in December, 2016. The papers included discuss a wide range of statistical challenges, methods and applications for big data in production engineering, and introduce recent advances in relevant statistical methods.

Author: Peter H. Westfall
Publisher: John Wiley & Sons
ISBN: 9780471557616
Category : Mathematics
Languages : en
Pages : 382

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Book Description
Combines recent developments in resampling technology (including the bootstrap) with new methods for multiple testing that are easy to use, convenient to report and widely applicable. Software from SAS Institute is available to execute many of the methods and programming is straightforward for other applications. Explains how to summarize results using adjusted p-values which do not necessitate cumbersome table look-ups. Demonstrates how to incorporate logical constraints among hypotheses, further improving power.

Author: Douglas G. Altman
Publisher: CRC Press
ISBN: 1000228819
Category : Mathematics
Languages : en
Pages : 624

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Book Description
Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background. The author draws on twenty years of experience as a consulting medical statistician to provide clear explanations to key statistical concepts, with a firm emphasis on practical aspects of designing and analyzing medical research. Using real data and including dozens of interesting data sets, this bestselling text gives special attention to the presentation and interpretation of results and the many real problems that arise in medical research.

Author: Dimitris N. Politis
Publisher: Springer Science & Business Media
ISBN: 1461215544
Category : Mathematics
Languages : en
Pages : 359

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Book Description
Since Efron's profound paper on the bootstrap, an enormous amount of effort has been spent on the development of bootstrap, jacknife, and other resampling methods. The primary goal of these computer-intensive methods has been to provide statistical tools that work in complex situations without imposing unrealistic or unverifiable assumptions about the data generating mechanism. This book sets out to lay some of the foundations for subsampling methodology and related methods.

Author: Z. Govindarajulu
Publisher: World Scientific
ISBN: 9789812389053
Category : Mathematics
Languages : en
Pages : 338

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Book Description
This book contains topics that can be covered in a single-semester course. Only elementary proofs are provided, and thus the mathematics and statistics are maintained at a basic level. Only a course in each of three areas ? advanced calculus, probability and statistical inference ? is assumed of the student. The book has a chapter on applications to biostatistics and a supplement presenting computer programs for selected sequential procedures. Identified problems are provided at the end of each chapter.

Author: Thorsten Dickhaus
Publisher: Springer Science & Business Media
ISBN: 3642451829
Category : Science
Languages : en
Pages : 182

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Book Description
This monograph will provide an in-depth mathematical treatment of modern multiple test procedures controlling the false discovery rate (FDR) and related error measures, particularly addressing applications to fields such as genetics, proteomics, neuroscience and general biology. The book will also include a detailed description how to implement these methods in practice. Moreover new developments focusing on non-standard assumptions are also included, especially multiple tests for discrete data. The book primarily addresses researchers and practitioners but will also be beneficial for graduate students.

Author: John W. Berry
Publisher: Frontiers Media SA
ISBN: 2889713539
Category : Science
Languages : en
Pages : 192

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Book Description