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Author: Vinoth Jagaroo Publisher: Springer ISBN: 1461438462 Category : Psychology Languages : en Pages : 310
Book Description
The interest in ‘biomarkers’ seen across a spectrum of biomedical disciplines reflects the rise of molecular biology and genetics. A host of ‘omics’ disciplines in addition to genomics, marked by multidimensional data and complex analyses, and enabled by bioinformatics, have pushed the trajectory of biomarker development even further. They have also made more tractable the complex mappings of genotypes to phenotypes – genome-to-phenome mapping – to which the concept of a biomarker is central. Genomic investigations of the brain are beginning to reveal spectacular associations between genes and neural systems. Neural and cognitive phenomics are considered a necessary complement to genomics of the brain. Other major omics developments such as connectomics, the comprehensive mapping of neurons and neural networks, are heralding brain maps of unprecedented detail. Such developments are defining a new era of brain science. And in this new research environment, neural systems and cognitive operations are pressed for new kinds of definitions – that facilitate brain-behavioral alignment in an omics operating environment. This volume explores the topic of markers framed around the constructs of cognitive and neural systems. ‘Neurophenotype’ is a term adopted to describe a neural or cognitive marker that can be scientifically described within an associative framework – and while the genome-to-phenome framework is the most recognized of these, epigenetics and non-gene-regulated neural dynamics also suggest other frameworks. In either case, the term neurophenotype defines operational constructs of brain-behavioral domains that serve the integration of these domains with neuroscientific and omics models of the brain. The topic is critically important to psychiatry and neuropsychology: Neurophenotypes offer a ‘format’ and a ‘language’ by which psychiatry and neuropsychology can be in step with the brain sciences. They also bring a new challenge to the clinical neurosciences in terms of construct validation and refinement. Topics covered in the volume include: Brain and cognition in the omics era Phenomics, connectomics, and Research Domain Criteria Circuit-based neurophenotypes, and complications posed by non-gene regulated factors The legacy of the endophenotype concept – its utility and limitations Various potential neurophenotypes of relevance to clinical neuroscience, including Response Inhibition, Fear Conditioning and Extinction, Error Processing, Reward Dependence and Reward Deficiency, Face Perception, and Language Phenotypes Dynamic (electrophysiological) and computational neurophenotypes The challenge of a cultural shift for psychiatry and neuropsychology The volume may be especially relevant to researchers and clinical practitioners in psychiatry and neuropsychology and to cognitive neuroscientists interested in the intersection of neuroscience with genomics, phenomics and other omics disciplines.
Author: Vinoth Jagaroo Publisher: Springer ISBN: 1461438462 Category : Psychology Languages : en Pages : 310
Book Description
The interest in ‘biomarkers’ seen across a spectrum of biomedical disciplines reflects the rise of molecular biology and genetics. A host of ‘omics’ disciplines in addition to genomics, marked by multidimensional data and complex analyses, and enabled by bioinformatics, have pushed the trajectory of biomarker development even further. They have also made more tractable the complex mappings of genotypes to phenotypes – genome-to-phenome mapping – to which the concept of a biomarker is central. Genomic investigations of the brain are beginning to reveal spectacular associations between genes and neural systems. Neural and cognitive phenomics are considered a necessary complement to genomics of the brain. Other major omics developments such as connectomics, the comprehensive mapping of neurons and neural networks, are heralding brain maps of unprecedented detail. Such developments are defining a new era of brain science. And in this new research environment, neural systems and cognitive operations are pressed for new kinds of definitions – that facilitate brain-behavioral alignment in an omics operating environment. This volume explores the topic of markers framed around the constructs of cognitive and neural systems. ‘Neurophenotype’ is a term adopted to describe a neural or cognitive marker that can be scientifically described within an associative framework – and while the genome-to-phenome framework is the most recognized of these, epigenetics and non-gene-regulated neural dynamics also suggest other frameworks. In either case, the term neurophenotype defines operational constructs of brain-behavioral domains that serve the integration of these domains with neuroscientific and omics models of the brain. The topic is critically important to psychiatry and neuropsychology: Neurophenotypes offer a ‘format’ and a ‘language’ by which psychiatry and neuropsychology can be in step with the brain sciences. They also bring a new challenge to the clinical neurosciences in terms of construct validation and refinement. Topics covered in the volume include: Brain and cognition in the omics era Phenomics, connectomics, and Research Domain Criteria Circuit-based neurophenotypes, and complications posed by non-gene regulated factors The legacy of the endophenotype concept – its utility and limitations Various potential neurophenotypes of relevance to clinical neuroscience, including Response Inhibition, Fear Conditioning and Extinction, Error Processing, Reward Dependence and Reward Deficiency, Face Perception, and Language Phenotypes Dynamic (electrophysiological) and computational neurophenotypes The challenge of a cultural shift for psychiatry and neuropsychology The volume may be especially relevant to researchers and clinical practitioners in psychiatry and neuropsychology and to cognitive neuroscientists interested in the intersection of neuroscience with genomics, phenomics and other omics disciplines.
Author: Klaus A. Miczek Publisher: Springer Nature ISBN: 3031042565 Category : Medical Languages : en Pages : 517
Book Description
Social stress has emerged as a research front in the neurosciences, and this volume highlights recent insights in brain mechanisms and methodological advances. The topics range from the evolutionary origins of coping with social challenges to neural mechanism-driven focus on novel treatment targets. The parallel presentation of work with animal models and human subjects is bound to be useful to a broad research community.
Author: Robert T. Gerlai Publisher: Academic Press ISBN: 012817529X Category : Medical Languages : en Pages : 616
Book Description
Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. - Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field - Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish - Features examples of zebrafish models of human central nervous system disorders - Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics
Author: Rajkumar Rajendram Publisher: Academic Press ISBN: 0323903134 Category : Medical Languages : en Pages : 1742
Book Description
The Neuroscience of Pain, Anesthetics and Analgesics examines the syndromes of pain and how they interlink with anesthesia and analgesics. The book covers assessments, screening and resources, and provides applications to related areas of medicine. It explores how the perception of pain results from a multifaceted interaction between illness beliefs, age, gender, time of onset, stress, socioeconomic status, and other factors. In addition, it scrutinizes how the neuroscience of pain in one condition may be relevant to understanding pain observed in other conditions. Sections address the onset of pain, the cause of pain, and the administration of analgesia or anesthesia. The book works to clarify all of the subjects pertinent to anesthesia and the brain. Featuring chapters on neurotransmitters, pharmacology and brain imaging, this volume discusses the mechanisms of pain and experimental studies undertaken to better understand the pathways involved. - Includes content on the features and assessments of pain, anesthesia and analgesia - Provides a mini-dictionary of terms and summary points that succinctly encapsulate each chapter - Covers a broad range of topics related to the neuroscience of analgesics and anesthetics - Helps readers navigate key areas for research and further clinical recommendations - Features chapters on molecular pathways, imaging and a deep look at behavior associated with the experience of pain
Author: Gonzalo G. De Polavieja Publisher: Frontiers E-books ISBN: 2889193284 Category : Neurosciences. Biological psychiatry. Neuropsychiatry Languages : en Pages : 368
Book Description
Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.
Author: National Academies of Sciences, Engineering, and Medicine Publisher: National Academies Press ISBN: 0309488761 Category : Medical Languages : en Pages : 91
Book Description
To examine the promise, concerns, and challenges related to neuroscience research using genetically modified nonhuman primates, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop on October 4, 2018, bringing together an international group of experts and stakeholders representing academia, industry, laboratory animal management, disease-focused foundations, and federal agencies. The workshop was designed to explore the current state and future promise of research using genetically modified nonhuman primate models of disease to understand the complex functions of the brain that control behavior, movement, and cognition in both health and disease states. This publication summarizes the presentations and discussions from the workshop.
Author: Marcus Jacobson Publisher: Springer Science & Business Media ISBN: 1489917810 Category : Medical Languages : en Pages : 394
Book Description
The author makes a unique contribution to the field by discussing the history and philosophy of the neurosciences, and then developing critical approaches which integrate techniques, theory, and ethics. Taken as a whole, Jacobson's work will provide a coherent and humane framework for future research programs. The paperback edition of this highly successful text, first published in 1993, is now available! The author brings the ethics of neuroscience into a closer relationship with empirical research. Covering the field's history, philosophy, theories, and techniques, this volume provides the necessary moral and ethical framework to evaluate neuroscience research.
Author: Zoran Josipovic Publisher: Frontiers Media SA ISBN: 2889199711 Category : Psychology Languages : en Pages : 168
Book Description
A recent wave of brain research has advanced our understanding of the neural mechanisms of conscious states, contents and functions. A host of questions remain to be explored, as shown by lively debates between models of higher vs. lower-order aspects of consciousness, as well as global vs. local models. (Baars 2007; Block, 2009; Dennett and Cohen, 2011; Lau and Rosenthal, 2011). Over some twenty-five centuries the contemplative traditions have also developed explicit descriptions and taxonomies of the mind, to interpret experiences that are often reported in contemplative practices (Radhakrishnan & Moore, 1967; Rinbochay & Naper, 1981). These traditional descriptions sometimes converge on current scientific debates, such as the question of conceptual vs. non-conceptual consciousness; reflexivity or “self-knowing” associated with consciousness; the sense of self and consciousness; and aspects of consciousness that are said to continue during sleep. These real or claimed aspects of consciousness have not been fully integrated into scientific models so far. This Research Topic in Consciousness Research aims to provide a forum for theoretical proposals, new empirical findings, integrative literature reviews, and methodological improvements inspired by meditation-based models. We include a broad array of topics, including but not limited to: replicable findings from a variety of systematic mental practices; changes in brain functioning and organization that can be attributed to such practices; their effects on adaptation and neural plasticity; measurable effects on perception, cognition, affect and self-referential processes. We include contributions that address the question of causal attribution. Many published studies are correlational in nature, because of the inherent difficulty of conducting longitudinal experiments based on a major lifestyle decision, such as the decision to commit to a mental practice over a period of years. We also feature clinical and case studies, integrative syntheses and significant opinion articles.
Author: Vinoth Jagaroo
Author: Vinoth Jagaroo
Author: Klaus A. Miczek
Author: Jurong Ding
Author: Robert T. Gerlai
Author: Rajkumar Rajendram
Author: Gonzalo G. De Polavieja
Author: National Academies of Sciences, Engineering, and Medicine
Author: Marcus Jacobson
Author: Rosalba Morese
Author: Zoran Josipovic