Author: John Henry Rossmeisl
Publisher: Frontiers Media SA
ISBN: 2832504906
Category : Medical
Languages : en
Pages : 103

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Book Description

Author: Joseph Rogers
Publisher: Birkhäuser
ISBN: 3034883501
Category : Medical
Languages : en
Pages : 266

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Book Description
Research into inflammatory mechanisms that may cause damage to the Alzheimer's disease (AD) brain has now been ongoing for nearly two decades. Some two dozen clinical studies have strongly suggested that conventional anti-inflammatory drugs may be useful to delay the onset or slow the progression of the disorder. Moreover, virtually all the major systems of the innate immune response appear to be present, and most are upregulated, in pathologically-vulnerable regions of the AD brain. These new findings are described in this volume - first in overview form, followed by chapters on topics of special interest. In many ways, to understand AD brain inflammation, one need only review a text on peripheral inflammation biology, leaving out the chapters on humoral medi ators and substituting microglia for macrophages. In several other key respects, however, AD brain inflammation is unique, due primarily to idiosyncratic interac tions of inflammatory mediators and mechanisms with classical AD pathology: amyloid ~ peptide(A~) deposits and neurofibrillary tangles (NFTs). For this reason, some key concepts about the inflammation that occurs in AD may warrant discus sion in preparation for the more detailed chapters that follow.

Author: Rebecca A. Krimins
Publisher: CRC Press
ISBN: 0429509111
Category : Medical
Languages : en
Pages : 224

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Book Description
Learning from Disease in Pets: A ‘One Health’ Model for Discovery is the first encompassing reference guide for veterinarians, researchers and physicians on conducting studies using spontaneous models of disease in animals. The study of naturally occurring disease in (pet) animals can help model our understanding of the biology, prevention and therapy of human and animal diseases. Studies of pet dogs, for instance, can aid treatment of complex medical problems such as cancer, orthopedic, cardiopulmonary, and neuro-inflammatory diseases, and zoonotic infections. Each chapter within this novel cross-species approach is contributed by a leader, or leaders, in their field of research. Using clinical trials to learn how pets with real diseases respond to therapy can lead to breakthroughs in human medicine, as well as benefiting pets suffering from otherwise debilitating illness. Despite similarities of diseases across species, there are very few spontaneous models of disease used in research compared with models where disease is induced in healthy laboratory animals. Many medical researchers and veterinarians have a multitude of questions regarding how to use naturally occurring diseases in pets for the discovery of treatments and diagnostics: this book will demonstrate how to safely make this happen. This book encourages veterinarians to build on and disseminate existing findings for the wider benefit of pets and humans. Many pets suffering from incurable illnesses may benefit from clinical trials; the book includes a section on the imperative communication styles necessary within the research environment and with clients, a compelling discussion on the ethics of using pets in veterinary clinical research, comprehensive tables of diseases that spontaneously occur in animals and humans, the regulatory requirements necessary to move therapy from benchside research to patient bedside, as well as intricate details on how to design a robust clinical study.

Author: Rebecca A. Krimins
Publisher: CRC Press
ISBN: 0429508492
Category : Medical
Languages : en
Pages : 294

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Book Description
Learning from Disease in Pets: A ‘One Health’ Model for Discovery is the first encompassing reference guide for veterinarians, researchers and physicians on conducting studies using spontaneous models of disease in animals. The study of naturally occurring disease in (pet) animals can help model our understanding of the biology, prevention and therapy of human and animal diseases. Studies of pet dogs, for instance, can aid treatment of complex medical problems such as cancer, orthopedic, cardiopulmonary, and neuro-inflammatory diseases, and zoonotic infections. Each chapter within this novel cross-species approach is contributed by a leader, or leaders, in their field of research. Using clinical trials to learn how pets with real diseases respond to therapy can lead to breakthroughs in human medicine, as well as benefiting pets suffering from otherwise debilitating illness. Despite similarities of diseases across species, there are very few spontaneous models of disease used in research compared with models where disease is induced in healthy laboratory animals. Many medical researchers and veterinarians have a multitude of questions regarding how to use naturally occurring diseases in pets for the discovery of treatments and diagnostics: this book will demonstrate how to safely make this happen. This book encourages veterinarians to build on and disseminate existing findings for the wider benefit of pets and humans. Many pets suffering from incurable illnesses may benefit from clinical trials; the book includes a section on the imperative communication styles necessary within the research environment and with clients, a compelling discussion on the ethics of using pets in veterinary clinical research, comprehensive tables of diseases that spontaneously occur in animals and humans, the regulatory requirements necessary to move therapy from benchside research to patient bedside, as well as intricate details on how to design a robust clinical study.

Author: Marc Vandevelde
Publisher: John Wiley & Sons
ISBN: 1118349490
Category : Medical
Languages : en
Pages : 228

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Book Description
Introducing the theoretical and practical basics of veterinary neuropathology, this concise and well illustrated book is an essential basic diagnostic guide for pathologists, neurologists and diagnostic imaging specialists. It presents readers with strategies to deal with neuropathological problems, showing how to interpret gross and histological lesions using a systematic approach based on pattern recognition. It starts with an overview of the general principles of neuroanatomy, neuropathological techniques, basic tissue reaction patterns, and recognition of major lesion patterns. The book goes on to cover vascular diseases, inflammatory diseases, trauma, congenital malformations, metabolic-toxic diseases, neoplasia and degenerative diseases mainly of the central nervous system. In the respective chapters pathologists can quickly find information to support their daily diagnostic workup for both small and large domestic species. Based on the authors’ extensive diagnostic and post graduate teaching experience as well as the inclusion of MRI as it relates to neuropathology, this book also offers a comprehensive but basic analysis of veterinary neuropathology that neurologists and other MRI users will find very useful. An essential manual for daily diagnostic work Richly illustrated with high quality colour gross, histological and MRI images Includes a section on the function and use of MRI (by Johann Lang, DECVDI) Accompanied by a website presenting MRI sequences for interpretation and correlation with neuropathological findings edited by Johann Lang (University of Bern, Switzerland) and Eric Wiesner (University of California, Davis, USA) www.wiley.com/go/vandevelde/veterinaryneuropathology

Author: Anne Waugh
Publisher: Elsevier Health Sciences
ISBN: 0323834620
Category : Medical
Languages : en
Pages : 600

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Book Description
Now in its fourteenth edition, this best-selling textbook has been honed over many years to provide a clear, straightforward introduction to the human body for students of nursing, allied health or biomedical and paramedical science. The book covers the core essentials of anatomy and physiology, including basic pathology and pathophysiology of important diseases and disorders. This new edition presents additional illustrations to enhance understanding of key concepts, including pathophysiology and diagnostics. Included for the first time is an introduction to surface anatomy, while other updating reflects current scientific knowledge and developments, including coronavirus. Enhanced learning features and an extensive online resource help you grasp all the important areas. Like millions of readers before you, you will treasure Ross & Wilson as a go-to resource that you will refer to time and again to support this critical aspect of your healthcare education. - Clear and easy to read – suitable for students new to the area and anyone whose first language is not English - Hundreds of stunning illustrations and images to make learning easy - Helpful learning features such as Learning Outcomes boxes, colour coding and orientation icons to facilitate navigation - Definitions of common prefixes, suffixes and roots, examples, glossary and an appendix of normal biological values - Self-assessment activities in each chapter, including 'spot check' questions for each section and case studies with answers to develop understanding of key principles - Accompanying website with animations, videos, audio-glossary and other self-assessment material Evolve Study Resources Online content offered with Ross & Wilson Anatomy and Physiology in Health and Illness 14th edition includes: - New for this edition – a set of expert-narrated 3D videos summarizing key topics in the book, powered by Complete Anatomy: the world's most advanced 3D anatomy platform - Over 120 animations clarifying underlying principles and make learning fun - More than 1700 audio glossary entries - Body Spectrum © online colouring and self-test software - Self-assessment questions to help students test their knowledge

Author: Ryszard M. Kozlowski
Publisher: Woodhead Publishing
ISBN: 0128190701
Category : Science
Languages : en
Pages : 754

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Book Description
The Handbook of Natural Fibres: Volume Two, Processing and Applications, Second Edition provides detailed coverage of the latest processing techniques and industrial applications of a wide range of natural fibers. Natural fibrous resources, both lignocellulosic and protein ones, are renewable, biodegradable, and nontoxic, making them an important source of sustainable textile solutions. A broad range of sources of natural fibers are covered in the book, including flax, hemp, bast, jute, coir, linen, cotton and silk. This wealth of expert information provides a uniquely detailed reference for the processing, characterization, selection and application of natural fibers. - Connects natural fibers to a wide range of industries, including construction, automotive, packaging and medical - Helps readers appraise natural fibers on the basis of their mechanical, electrokinetic, antimicrobial or flame retardant qualities - Provides a rare glimpse of emerging manufacturing methods for silk

Author: Vincenzo Di Marzo
Publisher: Academic Press
ISBN: 0128004290
Category : Medical
Languages : en
Pages : 208

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Book Description
The Endocannabinoidome: The World of Endocannabinoids and Related Mediators is dedicated to the latest research and studies on endocannabinoids and cannabinoid receptors to illustrate their important role in the discovery of new, endocannabinoid-related, lipid mediators. Written by leading experts across different disciplines, this book focuses on the biochemical and anlayticial aspects of novel lipid signals, their pharmacological activities and their potential utilization for the development of new and effective therapeutic strategies. The first book of its kind, The Endocannabinoidome is a meaningful reference for all those involved in experimental efforts to further the development of this field. - Explores the novel and exciting aspects of several endocannabinoid-like molecules for which researchers are still seeking a function - Discusses the novel metabolic pathways for endocannabinoids in order to explain the failure of some clinical trials with inhibitors of more conventional metabolic pathways - Incorporates pharmacology, biochemistry and potential clinical applications to provide researchers with a complete look at endocannabinoids

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1872

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Book Description

Author: Graham A.W. Rook
Publisher: Springer Science & Business Media
ISBN: 3764389036
Category : Medical
Languages : en
Pages : 312

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Book Description
Man has moved rapidly from the hunter-gatherer environment to the living conditions of industrialised countries. The hygiene hypothesis suggests that the resulting reduced exposure to micro-organisms has led to disordered regulation of the immune system, and hence to increases in certain chronic inflammatory disorders, like allergic disorders, autoimmunity, inflammatory bowel disease, atherosclerosis, depression, some cancers and perhaps Alzheimer and Parkinson. This book discusses the evidence for and against in the context of Darwinian medicine, which uses knowledge of evolution to cast light on human diseases. The approach is interdisciplinary, looking at man’s microbiological history, at the biology of the effects of microorganisms on the immune system, and at the implications for chronic inflammatory disorders in multiple organ systems. Finally, the authors describe progress in the exploitation of microorganisms or their components as novel prophylactics and treatments.