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Author: David D. Eisenstat Publisher: Springer Nature ISBN: 3031207920 Category : Medical Languages : en Pages : 816
Book Description
This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.
Author: David D. Eisenstat Publisher: Springer Nature ISBN: 3031207920 Category : Medical Languages : en Pages : 816
Book Description
This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.
Author: Andrew Fuller Publisher: ISBN: 9781951075958 Category : Languages : en Pages : 248
Book Description
Imagine schools where everyone learns at high levels. Not just some students. Every student. This resource aims to help educators bring these schools to life through the power of neurodevelopmental differentiation. Backed by scientific and educational research, the book outlines how to assess and build students' inherent strengths in eight major areas in order to increase engagement, mastery, and ultimately, success. Study eight brain processing systems and understand how developing strengths in these areas increases academic success. Discover how to identify students' learning strengths and needs. Learn how to develop individualized learning plans to fit the needs of all students. Contemplate reflective questions on the eight brain areas to determine next steps in your own classroom. Utilize free online reproducibles to further your understanding of the material presented in the book. Contents: Acknowledgments Table of Contents About the Authors Foreword Introduction Chapter 1: Spatial Reasoning Chapter 2: Perceptual and Motor Skills Chapter 3: Concentration and Memory Chapter 4: Planning and Sequencing Chapter 5: Thinking and Logic Chapter 6: People Smarts Chapter 7: Language and Word Smarts Chapter 8: Number Smarts Chapter 9: Implementing Neurodevelopmental Differentiation References and Resources Index
Author: Colin R Martin Publisher: Academic Press ISBN: 0128179899 Category : Psychology Languages : en Pages : 628
Book Description
Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. In addition, the book also examines the pharmacological and non-pharmacological interventions of development-related conditions. - Provides the most comprehensive coverage of the broad range of topics relating to the neuroscience of aging - Features sections on the genetics that influences aging and diseases of aging - Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter - Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations - Includes more than 500 illustrations and tables
Author: Bin Chen Publisher: Academic Press ISBN: 0128144106 Category : Medical Languages : en Pages : 428
Book Description
Neurodevelopmental Disorders, the latest release in the Comprehensive Developmental Neuroscience series, presents the most thorough coverage available, addressing all aspects on how the nervous system and its components develop. This book brings together the latest research in this rapidly evolving field, with section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neurodevelopmental disorders in humans and experimental organisms. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. - Features leading experts in various subfields as section editors and article authors - Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship - Covers disorders of the nervous system that arise through defects in neural development
Author: Emanuel DiCicco-Bloom Publisher: Springer Nature ISBN: 3030454932 Category : Medical Languages : en Pages : 307
Book Description
This book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.
Author: Kevin J. Mitchell Publisher: John Wiley & Sons ISBN: 1118524993 Category : Medical Languages : en Pages : 385
Book Description
Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.
Author: Dante Cicchetti Publisher: John Wiley & Sons ISBN: 1119125529 Category : Psychology Languages : en Pages : 2725
Book Description
The complete reference of biological bases for psychopathology at any age Developmental Psychopathology is a four-volume compendium of the most complete and current research on every aspect of the field. Volume Two: Developmental Neuroscience focuses on the biological basis of psychopathology at each life stage, from nutritional deficiencies to genetics to functional brain development to evolutionary perspectives and more. Now in its third edition, this comprehensive reference has been fully updated to better reflect the current state of the field, and detail the newest findings made possible by advances in technology and neuroscience. Contributions from expert researchers and clinicians provide insight into brain development, molecular genetics methods, neurogenics approaches to pathway mapping, structural neuroimaging, and much more, including targeted discussions of specific disorders. Advances in developmental psychopathology have burgeoned since the 2006 publication of the second edition, and keeping up on the latest findings in multiple avenues of investigation can be burdensome to the busy professional. This series solves the problem by collecting the information into one place, with a logical organization designed for easy reference. Consider evolutionary perspectives in developmental psychopathology Explore typical and atypical brain development across the life span Examine the latest findings on stress, schizophrenia, anxiety, and more Learn how genetics are related to psychopathology at different life stages The complexity of a field as diverse as developmental psychopathology deepens with each emerging theory, especially with consideration of the rapid pace of neuroscience advancement and genetic discovery. Developmental Psychopathology Volume Two: Developmental Neuroscience provides an invaluable resource by compiling the latest information into a cohesive, broad-reaching reference.
Author: Stéphane Martin Publisher: Springer Nature ISBN: 1071625691 Category : Medical Languages : en Pages : 271
Book Description
This volume explores the latest techniques used to study neurodevelopmental diseases (NDD) that range from molecular aspects to integrated research approaches and brain imaging in living rodents. Chapters in this book cover topics such as protocols to deliver shRNA in vitro and in vivo using lentiviral particles to knock-down specific protein expression; experimental procedures to use recombinant fluorescent probes to visualize endogenous proteins at the mammalian synapse; CRISPR/Cas9 toolkit to assess either gain- or loss-of-gene function in brain organoids; detailed protocols to use in vivo manipulations to correct the behavioral phenotypes in cognitive disorder mouse lines; and experimental approaches to genetically engineer macaque models of NDDs and investigate how genetic predisposition may cause neural and functional alterations. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Research Methods in Neurodevelopmental Disorders is a valuable resource for all researchers who want to learn more about this important and developing field.
Author: David D. Eisenstat
Author: David D. Eisenstat
Author: Andrew Fuller
Author: Colin R Martin
Author: Bin Chen
Author: Emanuel DiCicco-Bloom
Author: Kevin J. Mitchell
Author: Edna Grünblatt
Author: Dante Cicchetti
Author: Stéphane Martin
Author: Hongbao Cao