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Author: George Tetz Publisher: Frontiers Media SA ISBN: 2832526381 Category : Science Languages : en Pages : 159
Book Description
While there are growing line of evidence for the role of the gut microbiome in different neurodegenerative diseases, the role and even the existence of the brain microbiome is only starting to be uncovered. Indeed, the brain was long considered to be a sterile environment and only recent studies have shown the presence of bacteria and fungi in the human central nervous system, and even inhabiting brain cells. The so called “brain microbiome” is appealing and immediately drew attention, since it is highly possible that microorganisms could have profound direct effects on a variety of processes in the brain, with the non-limiting examples of neurodegenerative and neurodevelopmental diseases triggering and progression. However, the brain microbiome remains poorly understood and even despite recent technological advances, is has only began to be explored.
Author: George Tetz Publisher: Frontiers Media SA ISBN: 2832526381 Category : Science Languages : en Pages : 159
Book Description
While there are growing line of evidence for the role of the gut microbiome in different neurodegenerative diseases, the role and even the existence of the brain microbiome is only starting to be uncovered. Indeed, the brain was long considered to be a sterile environment and only recent studies have shown the presence of bacteria and fungi in the human central nervous system, and even inhabiting brain cells. The so called “brain microbiome” is appealing and immediately drew attention, since it is highly possible that microorganisms could have profound direct effects on a variety of processes in the brain, with the non-limiting examples of neurodegenerative and neurodevelopmental diseases triggering and progression. However, the brain microbiome remains poorly understood and even despite recent technological advances, is has only began to be explored.
Author: Alper Evrensel Publisher: BoD – Books on Demand ISBN: 1789848148 Category : Science Languages : en Pages : 115
Book Description
The gut-brain axis has gained considerable attention from different branches of the scientific community in recent years. In this book, scientists from different disciplines present current scientific knowledge on the topic. The interaction between the prokaryote and eukaryote cells stimulates the evolutionary processes, and results in various systemic illnesses such as neuropsychiatric disorders and may help the continuity of health. Nature has provided us with healthy food that builds our pharmacy. This natural pharmacy store may help the body's healing processes through its effects on gut microbiota and the immune system. This book aims to provide the reader with detailed analyses of the current scientific knowledge on the gut-brain axis and its relation with health and disease. We hope that the reader benefits from the presented material.
Author: Amit Kumar Tripathi Publisher: Springer Nature ISBN: 9811945306 Category : Medical Languages : en Pages : 315
Book Description
This book provides an overview of bidirectional communication between gut-microbiome-brain, pathways, nutrients, and metabolites that are involved in microbiota gut-brain axis (MGBA) interactions. Further it reviews the relevance of this axis in the neurological disorders and potential therapeutic interventions, involving gut microbiome or probiotics and prebiotics which can ameliorate the neurological disorders. The book examines the role of gut microbiota in the establishment and hemostasis of innate immune response and explores the possibility of development of microbiome-targeted therapeutic interventions. Notably, the book discusses the role of the gut microbiota and immune system on the maintenance of brain functions and the development of neurological disorders. It also highlights the recent advances in improving neurological diseases by phytochemicals, prebiotics and probiotics. This book is useful for researchers working in neuropharmacology, Clinical Research, toxicology, neurodegeneration, and stroke biology.
Author: Ulrich Dobrindt Publisher: Springer Science & Business Media ISBN: 3642365604 Category : Medical Languages : en Pages : 360
Book Description
This comprehensive, interdisciplinary book covers different aspects of relevant human pathogens and commensals. The ongoing development of (meta-)genomic, transcriptomic, proteomic and bioinformatic analyses of pathogenic and commensal microorganisms and their host interaction provides a comprehensive introduction to the microbiological analysis of host-microbe interplay and its consequences for infection or commensalism.
Author: G.M. Pasinetti Publisher: IOS Press ISBN: 164368289X Category : Medical Languages : en Pages : 732
Book Description
Despite being confined to the gastrointestinal tract, the gut microbiome has a wide impact on human physiology, supplementing its host’s biochemistry in a complex symbiotic relationship. Research in the field has evolved rapidly in the last decade, and we are now developing a better understanding of how our gut microbiome can influence our immune systems, metabolism, neurological signaling, and perhaps most unexpectedly, our brains; a phenomenon described as the gut-brain-axis. This book, ‘Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease’, sets out to explore the complex role of the microbiome with regard to Alzheimer’s disease (AD). The microbiome is a critical and often overlooked aspect of immunity, which in turn plays a role in cognition. The book presents current research into the gut microbiota and its far-reaching impacts on cognitive function and neurodegeneration. Interventions, including probiotic supplementation, fecal transfer, and supplementation with microbial metabolites, are discussed, as is the use of certain probiotics to study the effects of the gut microbiota on behavior and cognitive function, and as potential therapeutics for AD. Other topics covered include the influence of the gut and oral microbiota on immune inflammatory signals: cytokines, neuroendocrine hormones, bacterial components, neuroactive molecules, and microbial metabolites. The book is divided into four sections, each covering a research area pertinent to the gut-brain-axis and its relationship with cognitive function and AD. It will be of interest to all those whose work includes the study and understanding of these complex, multi-variable biological mechanisms, particularly in the context of cognitive function and AD. The cover shows a color edited MRI image of a sagittal section of a neurological control brain of Dr. Giulio Maria Pasinetti.
Author: Adrien A Eshraghi Publisher: World Scientific ISBN: 9811221162 Category : Science Languages : en Pages : 396
Book Description
In this book the recent advancements in understanding the gut-brain interaction as well as gut microbiome and how this interaction plays a vital role in human health and disease are discussed. Each chapter gives an analysis of questions, research directions, and methods within the field of gut-brain axis. The readers will benefit from the latest knowledge about our understanding about how gut-brain axis and modulation of gut microbiome determines predisposition to neurological disorders. The multidisciplinary book is essential reading for anyone interested in the field of gut-brain axis and gut microbiome: from undergraduates to graduate students as well as scientists and physicians having an interest in the new exciting field of gut microbiome and its relationship with brain function.
Author: Ukamushu Ann Undieh Publisher: ISBN: Category : Alzheimer's disease Languages : en Pages : 0
Book Description
Alzheimer's Disease (AD) and Parkinson's Disease (PD) are the two most common age-related chronic neurodegenerative diseases with significant global health burden. In addition to motor and cognitive impairments, these patients experience gut dysbiosis and gastrointestinal effects that may have a role in exacerbation of the neurological symptoms via the gut microbiome-brain axis. It has also been theorized that certain gut microbial-derived metabolites, indole metabolites of L-tryptophan are associated with neurodegeneration. Increasing evidence suggests that the bacteria that produce them are dysregulated in PD and AD patients. In this study, we used LCMS and Unifi analysis to measure and quantify the levels of these metabolites in fecal samples of rodents with PD or AD disease phenotype. In addition, we evaluated the levels of indole and its metabolites in PD animals treated with long-term L-DOPA which causes dyskinesia (LID) and LID rats treated with an experimental drug called S-SK609. The results showed decreases in the levels of indole-3-carbaldehyde and indole-3-acrylate with an increase in indole in PD animals; decreases in indole-3-carbaldehyde, indole-3-lactate and tryptophan in AD animals; and decreases in tryptophan, tryptamine, indole-3-lactate and indole-3-carbaldehyde with an increase in indole in LID animals. Treatment with the experimental drug S-SK609 had no ameliorating effect on metabolite levels in rodents with either LID or AD but it notably did not worsen the dysbiosis. Our findings validate that there is significant gut dysbiosis in neurodegeneration and measuring the levels of indole and its metabolites can serve as early biomarkers for neurodegeneration.
Author: Tahira Farooqui Publisher: Academic Press ISBN: 0128210400 Category : Medical Languages : en Pages : 388
Book Description
Gut Microbiota in Neurologic and Visceral Diseases presents readers with comprehensive information on the involvement of microbiota in the pathogenesis of neurological disorders. Chapters cover the effect of microbiota on the development of visceral (obesity, type 2 diabetes, heart disease) and neurological disorders (Alzheimer’s disease, Parkinson’s, depression, anxiety, and autism). Sections focus on the molecular mechanisms and signal transduction processes associated with the links among microbiota-related visceral and neurological disorders. It is hoped that this discussion will not only integrate and consolidate knowledge in this field but will also jumpstart more studies on the involvement of microbiota in the pathogenesis of neurological disorders. Reviews the relationship between gut microbiome, diseases and disorders Discusses the relationship between diet, microbiota and inflammation Includes neurodegenerative, neuropsychiatric and cardiovascular disorders Covers diabetes, obesity and metabolic disorders Identifies molecular mechanisms and signal transduction processes Encompasses dietary fiber, fat, prebiotics and probiotics
Author: Mark Lyte Publisher: Springer ISBN: 1493908979 Category : Science Languages : en Pages : 440
Book Description
The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (“us”). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.
Author: George Tetz
Author: George Tetz
Author: Alper Evrensel
Author: Amit Kumar Tripathi
Author: Ulrich Dobrindt
Author: G.M. Pasinetti
Author: Adrien A Eshraghi
Author: Ukamushu Ann Undieh
Author: Tahira Farooqui
Author: Surajit Pathak
Author: Mark Lyte