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Author: Fredrick J. Seil Publisher: Lippincott Williams & Wilkins ISBN: Category : Alzheimer's disease Languages : en Pages : 392
Book Description
Describes the mechanisms by which the nervous system is injured in disease and in trauma, examines repair or regenerative responses to neural injury, and explores therapeutic interventions aimed at promoting these responses.
Author: Fredrick J. Seil Publisher: Lippincott Williams & Wilkins ISBN: Category : Alzheimer's disease Languages : en Pages : 392
Book Description
Describes the mechanisms by which the nervous system is injured in disease and in trauma, examines repair or regenerative responses to neural injury, and explores therapeutic interventions aimed at promoting these responses.
Author: William M. Reichert Publisher: CRC Press ISBN: 1420009303 Category : Medical Languages : en Pages : 300
Book Description
Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel
Author: James B. Phillips Publisher: Springer ISBN: 9783030210519 Category : Technology & Engineering Languages : en Pages : 612
Book Description
This updatable book provides an accessible informative overview of the current state of the art in nerve repair research.The introduction includes history of nerve repair research and establishes key concepts and terminology and will be followed by sections that represent the main areas of interest in the field: (1) Biomaterials, (2) Therapeutic Cells, (3) Drug, Gene and Extracellular Vesicle Therapies, (4) Research Models and (5) Clinical Translation. Each section will contain 3 - 6 chapters, capturing the full breadth of relevant technology. Bringing together diverse disciplines under one overarching theme echoes the multidisciplinary approach that underpins modern tissue engineering and regenerative medicine. Each chapter will be written in an accessible manner that will facilitate interest and understanding, providing a comprehensive single reference source. The updatable nature of the work will ensure that it can evolve to accommodate future changes and new technologies. The main readership for this work will be researchers and clinicians based in academic, industrial and healthcare settings all over the world.
Author: Norman Saunders Publisher: CRC Press ISBN: 0203304489 Category : Medical Languages : en Pages : 354
Book Description
Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.
Author: Kwok Fai So Publisher: Academic Press ISBN: 0128018348 Category : Science Languages : en Pages : 444
Book Description
Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including: Neural regeneration in lower vertebrates Neural regeneration in the peripheral nervous system Neural regeneration in the central nervous system Transplantation-mediated neural regeneration Clinical and translational research on neural regeneration The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China. Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries. This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research. Provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration Highly translational and clinically-relevance International authors who are leaders in their respective fields Vivid art work making the chapters easily understood
Author: Ana Colette Maurício Publisher: BoD – Books on Demand ISBN: 9535131656 Category : Science Languages : en Pages : 226
Book Description
Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge.
Author: Hanno Millesi Publisher: Springer Science & Business Media ISBN: 3211729585 Category : Medical Languages : en Pages : 166
Book Description
All over the world research is going on to improve the outcome of the treatment of peripheral nerve lesions. Yet, there exist many questions, such as: Is the autologeous nerve grafting still the golden standard in bridging defects? Have alternative techniques to overcome defects reached a level to replace autografting? What can be expected from end to side coaptation? The contributions in this book give answers to all of these questions.
Author: Michael Miloro Publisher: Springer Science & Business Media ISBN: 3642355390 Category : Medical Languages : en Pages : 371
Book Description
Trigeminal nerve injuries present complex clinical challenges and can be very distressing for patients, resulting in abnormal sensations of the oro-facial region, yet surgeons may lack the knowledge required for optimal patient management based upon the specific nerve injury. This textbook is the first to be devoted to the diagnosis and management of trigeminal nerve injuries. A wide range of topics are covered, including historical perspectives, demographics, etiology, anatomy and physiology, pathophysiology, clinical neurosensory testing, nonsurgical management, and surgical management and principles of microneurosurgery, specifically involving the inferior alveolar and lingual nerves. Algorithms and a glossary are provided that will assist in the clinical management of these complex scenarios. The authors include surgeons with considerable experience and expertise in the field who have previously published on the subject. This book will serve as an ideal clinical reference for surgeons with patients who sustain trigeminal nerve injuries.
Author: George Davis Bittner Publisher: Frontiers Media SA ISBN: 2832544789 Category : Science Languages : en Pages : 142
Book Description
Peripheral nerve injuries (PNIs) by trauma are the most common neuronal injury in civilian and military populations and significantly burden health care systems. Mammals (including humans) with PNIs experience: (1) immediate loss of sensory and motor functions mediated by the denervated target tissues; (2) rapid (3-7d) Wallerian Degeneration (WD) of severed distal axonal segments; and, (3) slow (~1mm/day) regeneration by naturally occurring axonal outgrowths from surviving, severed proximal stumps that produce poor (if any) functional recovery because of slow axonal regeneration for long distances and lack of axonal guidance. Denervated muscle fibers and sensory organs often atrophy before any re-innervation can occur.
Author: Fredrick J. Seil
Author: Fredrick J. Seil
Author: William M. Reichert
Author: Giovanna Gambarotta
Author: James B. Phillips
Author: Norman Saunders
Author: Kwok Fai So
Author: Ana Colette Maurício
Author: Hanno Millesi
Author: Michael Miloro
Author: George Davis Bittner