Author: Kanti Bhooshan Pandey
Publisher: John Wiley & Sons
ISBN: 1119983312
Category : Science
Languages : en
Pages : 356

View

Book Description
Natural Products and their Bioactives in Antidiabetic Drug Discovery Enables researchers to effectively understand and use bioactive compounds to target, prevent, and manage diabetes Natural Products and Their Bioactives in Antidiabetic Drug Discovery provides readers with an overview of recent research in new drug discovery against diabetic complications based on bioactives from NPs, bridging the gap between the public research institutes and private companies working to find drugs to treat diabetes. To aid in reader comprehension, the text includes case studies and illustrated examples in relevant chapters. Part one presents chapters on fundamental concepts of diabetes mellitus (DM) and recent drug discovery progress along with the various druggable targets and challenges. Part two covers bioactive compounds targeting Type-1 Diabetes. Part three focuses on Type-2 Diabetes. In Part four, the contributors address gestational DM prevention and management with natural compounds. Written by a global team of experts in the field, Natural Products and their Bioactives in Antidiabetic Drug Discovery covers sample topics such as: Obesity risk factor in patients with T1DM and possible role of nutritional therapy in its management Use of natural non-insulin drugs as a novel approach to enhance therapeutic outcomes against T1DM Effectiveness of functional foods in intervening the diabetic complications and realistic results in clinical trials Implementation of nanotechnology in improving the bioavailability and reducing the threshold dose of bioactive compounds Various antidiabetic mechanisms of action of different polyphenols and immunomodulatory role of NPs bioactives relevance in T1DM therapy Effects of natural products on genetics of gestational diabetes With comprehensive coverage of recent research in new drug discovery against diabetic complications based on bioactives from NPs, Natural Products and Their Bioactives in Antidiabetic Drug Discovery is an essential resource for researchers and professionals involved in drug discovery and development, health care, medicinal chemistry, phytochemistry, plant science, and toxicology.

Author: Joginder Singh
Publisher: Springer Nature
ISBN: 9811513945
Category : Medical
Languages : en
Pages : 733

View

Book Description
This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.

Author: Goutam Brahmachari
Publisher: World Scientific
ISBN: 9814335371
Category : Science
Languages : en
Pages : 695

View

Book Description
Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Author: Goutam Brahmachari
Publisher: Elsevier
ISBN: 0128096926
Category : Medical
Languages : en
Pages : 334

View

Book Description
Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Author: Suresh R. Naik
Publisher: Elsevier Inc. Chapters
ISBN: 0128084928
Category : Science
Languages : en
Pages : 40

View

Book Description
Bioactive natural products are an excellent source of novel therapeutics. The search for bioactive molecules from nature continues to play a major role in developing new generation natural products of therapeutic importance. The present critical review includes research work carried out by active researchers in natural products’ chemistry, pharmacology and therapeutics, and their implications in antidiabetic medications. This compiled scientific information will be a useful resource for future research especially in indentifying promising leads and direction for the development of novel drugs including useful adjuvants for the treatment of diabetic patient. The present therapeutic approaches in the treatment of diabetes are mainly focused to lower the elevated blood glucose by reducing its absorption in gastrointestinal tract, enhancing the sensitivity of insulin, controlling or modulating hepatic glucose output, and increased utilization of the glucose by the peripheral tissues. Involvement of oxidative stress and its impact on the cellular damage in diabetes mellitus has been established and could be a useful paradigm for the development of novel antihyperglycemics along with other therapeutic strategies. The present review also highlights the effects of various herbs, phytoconstituents, phytochemicals, microbial metabolites, and products of marine origins on hyperglycemic/diabetic conditions. Furthermore, efforts were made to discuss novel molecular targets such as insulin-signaling pathways, peroxisome proliferative activating receptor-γ, and G-protein-coupled receptors that are participating in enhancing/influencing insulin secretion, critical carbohydrate metabolism pathways, endoplasmic reticulum stress-related pathways, intracellular events associated intracellular inflammation, and chromatin-modification pathways involvement in antidiabetic activity and their significance.

Author: Rupesh Chikhale
Publisher: Elsevier
ISBN: 9780443300868
Category : Science
Languages : en
Pages : 0

View

Book Description
Antidiabetic Drug Discovery from Natural Products provides up-to-date and in- depth information, practical understanding and guidance in a comprehensive, systematic and easy-to-understand manner to scientists, researchers, graduate students on important and emerging biochemical topics related to current antidiabetic drug discovery research. This book analyzes and studies natural active substances and their medicinal chemistry in preventing and treating diabetes and its complications. It covers a wide range of critical issues to assist chemists in the discovery and development of safer, more affordable treatments, from identifying promising leads from medicinal plants to the extraction and synthesis of bioactive compounds. Following an introduction to bioactive chemical compounds from plants with antidiabetic effects, "Antidiabetic Drug Discovery from Natural Products” describes the discovery and extraction of antidiabetic drugs and antioxidants from natural sources. It also examines antidiabetic plants before delving deeper into the chemistry behind major medicinal substances and their derivatives like Mangiferin and Resveratrol, discussing current and prospective uses. It intends to support and inspire medicinal chemists who are exploring natural sources as a starting point for creating standardized, safe, and effective antidiabetic therapies.

Author: Deepu Pandita
Publisher: CRC Press
ISBN: 100057511X
Category : Health & Fitness
Languages : en
Pages : 355

View

Book Description
This volume takes an in-depth look at the potential pharmacological applications of 11 important antidiabetic plants, examining their antihyperglycemic, hypoglycemic, and anti-lipidemic properties along with current genome editing research perspectives. Plant natural products, or phytoconstituents, are promising candidates for antidiabetic pharmacological actions. The phytoconstituents, such as fl avonoids, terpenoids, saponins, carotenoids, alkaloids and glycosides, play vital roles in the current and future potent antidiabetic drug development programs Each chapter reviews a particular plant with antidiabetic properties, explaining the therapeutic aspects, its active antidiabetic compounds, and relevant genome editing technology. The specific plants discussed include Azadirachta indica (commonly known as neem, nimtree or Indian lilac), Gymnema sylvestre (commonly called gymnema, Australian cowplant, and Periploca of the woods), Syzygium cumini (commonly known as Malabar plum, Java plum, black plum, jamun or jambolana), Ceylon cinnamon (or true cinnamon, as opposed to cassia cinnamon), insulin plant (or Costus pictus), Trigonella foenum-graecum (better known as fenugreek), Mulberry, Nigella sativa L. (black caraway, also known as black cumin, nigella, kalojeera, kalonji or kalanji), Aegle marmelos (L.) (commonly known as bael (or bili or bhel), also Bengal quince, golden apple, Japanese bitter orange, stone apple or wood apple), Ficus benghalensis (the banyan, banyan fig and Indian banyan), and of course, garlic (Allium sativum). Antidiabetic Plants for Drug Discovery: Pharmacology, Secondary Metabolite Profiling, and Ingredients with Insulin Mimetic Activity will serve as a valuable source of information for students, drug researchers, medical practitioners, diabetic patients, and many others in the effort to gain understand of how these plant drug molecules can help fight diabetes.

Author: Dilipkumar Pal
Publisher: Springer Nature
ISBN: 3030540278
Category : Technology & Engineering
Languages : en
Pages : 862

View

Book Description
This book covers the recent innovations relating to various bioactive natural products (such as alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, volatile oils, fixed oils, fats and waxes, proteins and peptides, vitamins, marine products, camptothecin, piperines, carvacrol, gedunin, GABA, ginsenosides) and their applications in the pharmaceutical fields related to academic, research and industry.

Author: Atta-ur- Rahman
Publisher: Bentham Science Publishers
ISBN: 1681082136
Category : Medical
Languages : en
Pages : 253

View

Book Description
Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.

Author:
Publisher:
ISBN: 9789811513954
Category : Drug development
Languages : en
Pages :

View

Book Description
This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the books closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the books goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.