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Author: Olesja Bondarenko Publisher: Mdpi AG ISBN: 9783036545998 Category : Languages : en Pages : 0
Book Description
Nanoparticles (NPs) offer unique properties for biomedical applications, leading to new nanomedicines. Recent examples of advanced nanoparticle-based nanomedicines are COVID-19 RNA vaccines. Regardless of the delivery route of the NPs into the body (intravenous or subcutaneous injection, oral, intranasal, etc.), NPs inevitably come into contact with immune cells, such as macrophages. Macrophages are phagocytizing cells that determine the fate and the lifetime of NPs in relevant biological fluids or tissues, which has consequences for both nanosafety and nanomedicine. The aim of this Special Issue is to cover recent advancements in our understanding of NP-macrophage interactions, with a focus on in vitro models for nanosafety and novel nanomedicine approaches that allow the modulation of the immunological profile of macrophages. The current Special Issue compiles nine papers: seven research articles and two review articles. The original articles include studies on the interaction of different nanomaterials, such as multi-walled carbon nanotubes (MWCNTs), amorphous silica, gold nanoparticles, lipid carriers, and microspheres, with macrophages in different scenarios.
Author: Olesja Bondarenko Publisher: Mdpi AG ISBN: 9783036545998 Category : Languages : en Pages : 0
Book Description
Nanoparticles (NPs) offer unique properties for biomedical applications, leading to new nanomedicines. Recent examples of advanced nanoparticle-based nanomedicines are COVID-19 RNA vaccines. Regardless of the delivery route of the NPs into the body (intravenous or subcutaneous injection, oral, intranasal, etc.), NPs inevitably come into contact with immune cells, such as macrophages. Macrophages are phagocytizing cells that determine the fate and the lifetime of NPs in relevant biological fluids or tissues, which has consequences for both nanosafety and nanomedicine. The aim of this Special Issue is to cover recent advancements in our understanding of NP-macrophage interactions, with a focus on in vitro models for nanosafety and novel nanomedicine approaches that allow the modulation of the immunological profile of macrophages. The current Special Issue compiles nine papers: seven research articles and two review articles. The original articles include studies on the interaction of different nanomaterials, such as multi-walled carbon nanotubes (MWCNTs), amorphous silica, gold nanoparticles, lipid carriers, and microspheres, with macrophages in different scenarios.
Author: Masayoshi Okubo Publisher: Springer Science & Business Media ISBN: 9783540229230 Category : Technology & Engineering Languages : en Pages : 388
Book Description
In this special volume on polymer particles, recent trends and developments in the synthesis of nano- to micron-sized polymer particles by radical polymerization (Emulsion, Miniemulsion, Microemulsion, and Dispersion Polymerizations) of vinyl monomers in environmentally friendly heterogeneous aqueous and supercritical carbon dioxide fluid media are reviewed by prominent worldwide researchers. In addition to the important challenges and possibilities with regards to design and preparation of functionalized polymer particles of controlled size, the topics described are of great current interest due to the increased awareness of environmental issues.
Author: Swati Gupta Publisher: Springer Nature ISBN: 3030841642 Category : Medical Languages : en Pages : 550
Book Description
The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting. Macrophages have gained substantial attention as therapeutic targets for drug delivery considering their major role in health and regulation of diseases. Macrophage-targeted therapeutics have now added significant value to the lives and quality of life of patients, without undue adverse effects in multiple disease settings. We anticipate examining and integrating the role of macrophages in the instigation and advancement of various diseases. The major focus of the book is on recent advancements in various targeting strategies using delivery systems or nanocarriers followed by application of these nanocarriers for the treatment of macrophage associated disorders. Macrophage Targeted Delivery Systems is primarily targeted to Pharmaceutical Industry & Academia, Medical & Pharmaceutical Professionals, Undergraduate & Post graduate students and Research Scholars, Ph.D, post docs working in the field of medical and pharmaceutical sciences.
Author: Barbara Klajnert Publisher: Royal Society of Chemistry ISBN: 1849736111 Category : Medical Languages : en Pages : 215
Book Description
This book will provide comprehensive coverage of dendrimer applications and clear indications for future research. It will appeal to chemists, biologists and materials scientists, working in both academia and industry.
Author: Masoud Rahman Publisher: Springer Science & Business Media ISBN: 3642375553 Category : Science Languages : en Pages : 95
Book Description
In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
Author: Raha Ahmadkhanbeigi Publisher: ISBN: Category : Languages : en Pages : 318
Book Description
Introduction. Conjugated polymer nanoparticles (CPN) have attracted wide attention for potential applications in bio-imaging and as theranostics due to their unique properties including strong photoluminescence, excellent photostability and broad absorption spectra. Despite the promising applications of CPNs, there are only a few studies in the literature investigating the biocompatibility profile of these systems. In this project the impact of various CPN compositions (core/shell materials) on particle properties, their behaviour in biological environments and their interactions with human blood cells, was investigated. Methods. Poly[(9,9-di-n-octylfluorenyl-2, 7-diyl)-alt-(benzo[2, 1,3]thiadiazol-4,8-diyl)] (F8BT), poly[2,5-di(3 ', 7 '-dimethyloctyl)phenylene-1,4-ethynylene] (PPE) and poly[2- methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV) CPNs were synthesised using mini-emulsion technique utilising sodium dodecyl sulphate (SDS), a charged stabiliser, PEG(0.6kDa)-12-hydroxystearate (Solutol ®HS 15), a steric stabiliser, or a mix of lipidic 1,2- dipalmitoyl-sn-glycero-3-phosphotidylcholine (DPPC) and PEG(2K)phosphotidylethanolamine, as a stabilising shell. Zeta-potential and hydrophilic-interactionchromatography were used to study nanoparticle surface properties and protein corona formation. The impact of surface properties on nanoparticle internalisation, cytokine release and cytotoxicity was investigated in J77 4A.1 cell line, and the interactions of CPN s with human blood components was studied by investigating the affect of the particles on induction of haemolysis, activation and agglomeration of platelets and platelet-monocyte adhesion.
Author: R. Navanietha Krishnaraj Publisher: John Wiley & Sons ISBN: 1119617197 Category : Technology & Engineering Languages : en Pages : 420
Book Description
MICROBIAL INTERACTIONS AT NANOBIOTECHNOLOGY INTERFACES This book covers a wide range of topics including synthesis of nanomaterials with specific size, shape, and properties, structure-function relationships, tailoring the surface of nanomaterials for improving the properties, interaction of nanomaterials with proteins/microorganism/eukaryotic cells, and applications in different sectors. This book also provides a strong foundation for researchers who are interested to venture into developing functionalized nanomaterials for any biological applications in their research. Practical concepts such as modelling nanomaterials, and simulating the molecular interactions with biomolecules, transcriptomic or genomic approaches, advanced imaging techniques to investigate the functionalization of nanomaterials/interaction of nanomaterials with biomolecules and microorganisms are some of the chapters that offer significant benefits to the researchers.
Author: Olesja Bondarenko
Author: Olesja Bondarenko
Author: Heather Leigh Herd
Author: MHD Kamal Al-Hallak
Author: Masayoshi Okubo
Author: Swati Gupta
Author: Barbara Klajnert
Author: Masoud Rahman
Author: Raha Ahmadkhanbeigi
Author: R. Navanietha Krishnaraj
Author: Nader Rifai