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Author: Eugene I. Chazov Publisher: Springer Science & Business Media ISBN: 1475744412 Category : Medical Languages : en Pages : 624
Book Description
This volume of Advances in Myocardiology is derived from a part of the proceedings of the 10th Congress of the International Society for Heart Research, which was held in Moscow on September 23-29, 1980. This book contains selected papers which have been arranged in two sections, Cardiac Hypertrophy, Adaptation, and Pathophysiology and Cardiac Hypoxia, Is chemia, and Infarction. The first section, on the pathophysiology of heart hypertrophy and failure, contains 24 chapters that focus on the derangement of biochemical, physiological, and immunological processes during the de velopment of heart disease due to a wide variety of pathogenic factors. Some of the recent developments in understanding the myocardial synthetic ma chinery in heart hypertrophy are also described in these papers, and we believe that the contents of this section will stimulate further research in the area of heart disease. The second section, which mainly deals with myocardial ischemia, contains 35 chapters providing the necessary back ground for the diagnosis of ischemic heart disease and some possible ther apeutic approaches. It hardly needs to be emphasized that ischemic heart disease is a major cause of death in highly industrialized countries, but unfortunately the exact mechanism by which ischemic insult leads to the development of heart cell damage is far from understood. We are hopeful that the articles in this section will provide valuable information in this field and thus will help in improving the treatment of ischemic heart disease.
Author: Eugene I. Chazov Publisher: Springer Science & Business Media ISBN: 1475744412 Category : Medical Languages : en Pages : 624
Book Description
This volume of Advances in Myocardiology is derived from a part of the proceedings of the 10th Congress of the International Society for Heart Research, which was held in Moscow on September 23-29, 1980. This book contains selected papers which have been arranged in two sections, Cardiac Hypertrophy, Adaptation, and Pathophysiology and Cardiac Hypoxia, Is chemia, and Infarction. The first section, on the pathophysiology of heart hypertrophy and failure, contains 24 chapters that focus on the derangement of biochemical, physiological, and immunological processes during the de velopment of heart disease due to a wide variety of pathogenic factors. Some of the recent developments in understanding the myocardial synthetic ma chinery in heart hypertrophy are also described in these papers, and we believe that the contents of this section will stimulate further research in the area of heart disease. The second section, which mainly deals with myocardial ischemia, contains 35 chapters providing the necessary back ground for the diagnosis of ischemic heart disease and some possible ther apeutic approaches. It hardly needs to be emphasized that ischemic heart disease is a major cause of death in highly industrialized countries, but unfortunately the exact mechanism by which ischemic insult leads to the development of heart cell damage is far from understood. We are hopeful that the articles in this section will provide valuable information in this field and thus will help in improving the treatment of ischemic heart disease.
Author: Peter Harris Publisher: Springer Science & Business Media ISBN: 1475712871 Category : Medical Languages : en Pages : 354
Book Description
The Eleventh World Congress of the International Society for Heart Re search 1983 provided an opportunity to review some of the growing points in our knowledge of the structure and function of the myocardium. Those at the meeting will recall how London suddenly went tropical. Yet aseries of scintillating reviews held over six hundred scientists captive in the lecture halls of Imperial College. There were sessions on nuclear magnetic reso nance, the molecular basis of electrophysiology, calmodulin, protein syn thesis and degradation, oxygen free radicals, the structural components of the myocyte, sarcolemmal sodium exchange, and the influence of lipids on membranes. Here we have gathered together, as quickly as possible, a number of the presentations of the speakers invited to the symposia. They give, we believe, a striking picture ofthe diversity oftechnology and scientific enquiry which underlies this immensely active domain of modern cardiology. If only our clinical colleagues were more aware of it! Peter Harris Philip A. Poole-Wilson London v Contents Evolution, Cardiac Failure, and Water Metabolism: Presidential Address . . . . . . . . . . . . . . . . . . .
Author: E. Gordon DePuey Publisher: Lippincott Williams & Wilkins ISBN: 9780781720076 Category : Medical Languages : en Pages : 366
Book Description
Cardiac SPECT Imaging, Second Edition offers the best of all possible worlds--a critical topic, internationally recognized authors and cutting-edge coverage. It guides you through all aspects of the modality--from basic principles (acquiring and processing images, quality control)...and clinical applications (evaluating myocardial infarction and coronary artery disease)...to the very latest equipment. It even compares SPECT with other modalities (PET, CT, MRI, and echocardiography) to ensure smart, cost-effective decisions by both the cardiologist and nuclear medicine physician.Look for new chapters on attenuation correction, gated perfusion SPECT, radiopharmaceuticals, and myocardial perfusion SPECT, as well as the very latest on myocardial perfusion SPECT in conjunction with exercise and pharmacologic stress, assessment of perfusion/viability with Tc-99m agents, how SPECT compares with other advanced cardiac imaging modalities, and more!
Author: Naranjan S. Dhalla Publisher: Springer Science & Business Media ISBN: 1461320550 Category : Medical Languages : en Pages : 352
Book Description
Whenever the coronary flow is inadequate to provide enough oxygen to meet the energy demands of the tissue, the heart becomes ischemic. Manifestations of myocardial ischemia include depression in contractile activity, changes in metabolic pattern, abnormalities in ultrastructure, and alterations in membrane potential. Ischemic changes during the early phase are reversible but as the period of ischemia is extended, the injury becomes irreversible. The transition from reversible to irreversible ischemic injury is usually associated with some membrane defects. It is worthwhile to consider that the irreversible damage to the ischemic myocardium occurs when the sarcolemmal membrane is altered in suoh a way that it would promote 2 a net gain of ca + in the cardiac cell upon reinstitution of blood flow. Suoh a lesion could result when mechanisms for the entry as well as removal 2 of ca + from the myocardial oell become defective. In this regard, 2 depression of the sarcolemmal ca + pump would favour the oocurrenoe of 2 intracellular ca + overload. Furthermore, inhibition of the Na+-K+ pump would lead to elevation of myoplasmic Na+ which oould then increase the 2 2 intracellular concentration of ca + through the sarcolemmal Na+-ca + exchange mechanism. In faot recent studies have revealed an inhibition of 2 the sarcolemmal Na+-ca + exchange mechanism in the ischemic heart and this 2 change could also contribute towards the occurrence of intracellular ca + 2 overload.
Author: R. Ferrari Publisher: Springer Science & Business Media ISBN: 146844865X Category : Medical Languages : en Pages : 337
Book Description
Over the past years, the thrust of research in cardiology has been toward an understanding of the engineering of the heart as a pump that transports blood to the various organs of the body. More recently, the fields of biochemistry and biophysics have come to influence heart research. The modern cardiologist can no longer pretend to understand, for example, what is happening to the patient with myocardial infarction or ischemia without understanding the principles of molecular biology. The structure and function of the heart are therefore central themes of cardiological research and practice, which incorporate knowledge and discoveries from diverse disciplines. The importance of lipid metabolism in the myocardium has become clearly understood. In the well-oxygenated heart, fatty acids are the preferred substrates. The fact that the heart derives most of its energy from the oxidation of lipids, which represent the larg est energy store of the body, is logical for an organ that must work throughout our lifetime. There are, however, several lines of evidence that during ischemia, lipids may. be harmful to the heart. High levels of free fatty acids in the serum have been suggested to play a role in causing life-threatening arryhthmias and damage in the ischemic heart. The molecular basis for these effects remains poorly understood, and several possible mechanisms for these harm ful effects have been suggested.
Author: H.M. Piper Publisher: Springer Science & Business Media ISBN: 9400904754 Category : Medical Languages : en Pages : 420
Book Description
In industrialized countries, ischemic heart disease is by far the most common organ-specific cause of death. The thrombotic occlusion of a coronary artery which had previously been severely altered by atherosclerosis, is the most frequent cause of ischemic deterioration of myocardial tissue, i. e. myocardial infarction. Death of the human individual occurs when myocardial ischemia causes a critical impairment of cardiac pump function. The failure of a heart with an ischemic area may be due to the amount and location of contractile tissue becoming paralyzed or even necrotic, or to arrhythmias provoked by the ischemic condition, or by a combination of both factors. Considerable progress has been made in the development of antiarrythmic therapy. Effective tools have been developed to reperfuse ischemic myocar dial tissue as soon as the patient reaches hospital. However, therapeutical principles for the ischemic-reperfused myocardium which would specifically interfere with the state of injury of the ischemic tissue at the onset of reperfusion, and avoid the apparent hazards of the reperfusion process itself, have yet to be established. But not only approved therapeutical concepts are lacking, the pathophysiology of myocardial cell injury in pro gressive ischemia and under reperfusion is in itself only partly understood.
Author: Eugene I. Chazov
Author: Eugene I. Chazov
Author: Peter Harris
Author: Wilhelm Raab
Author: 
Author: Wilhelm Raab
Author: Eörs Bajusz
Author: E. Gordon DePuey
Author: Naranjan S. Dhalla
Author: R. Ferrari
Author: H.M. Piper