Pathologic Conditions of the Human Nervous and Muscular Systems Associated with Mutant Chaperones: Molecular and Mechanistic Aspects PDF Download

Author: Alberto J. L. Macario
Publisher: Frontiers Media SA
ISBN: 2889454576
Category :
Languages : en
Pages : 111

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Book Description
This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.

Author: Ygal Haupt
Publisher: Frontiers Media SA
ISBN: 2889199614
Category : Medicine (General)
Languages : en
Pages : 99

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Book Description
TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation.

Author: Anthony Faber
Publisher: Academic Press
ISBN: 0128228342
Category : Science
Languages : en
Pages : 150

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Book Description
Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer. - Presents historical context on how NSCLC and SCLC has been treated, with an emphasis on NSCLC and how the concept of EGFR inhibitors has been implemented - Discusses critical resistant mechanisms seen in the clinic to 1st, 2nd and 3rd generation EGFR inhibitors - Encompasses the current state of affairs in clinical trials to address resistance

Author: Marco Cordani
Publisher: Frontiers Media SA
ISBN: 288971537X
Category : Medical
Languages : en
Pages : 174

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Author: Swati Palit Deb
Publisher: Springer
ISBN: 9401792119
Category : Medical
Languages : en
Pages : 376

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Book Description
This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.

Author: Yaxiong Zhang
Publisher: Frontiers Media SA
ISBN: 2832503802
Category : Medical
Languages : en
Pages : 239

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Book Description

Author: Arnold Brams Grobman
Publisher:
ISBN:
Category : Chromosomes
Languages : en
Pages : 6

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Book Description

Author: John P. Sundberg
Publisher: John Wiley & Sons
ISBN: 1119624576
Category : Medical
Languages : en
Pages : 564

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Book Description
An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

Author: Jim Lawson
Publisher: IDW Publishing
ISBN: 1623025605
Category : Comics & Graphic Novels
Languages : en
Pages : 135

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Book Description
Volume 8 begins collecting the Mirage Studios series Teenage Mutant Ninja Turtles Volume 2 that ran from 1993_1995. Includes the stories "Memories of the Future," "Winds of Change," "Evolution," "Intruders," and "Death Race", all written and drawn by Turtles veteran Jim Lawson.

Author: Tom Waltz
Publisher: IDW Publishing
ISBN: 1684067987
Category : Comics & Graphic Novels
Languages : en
Pages : 156

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Book Description
It's all been leading up to this! A massive showdown on the streets of NYC! Everything comes together in this explosive story that sees New York City torn apart by different factions, mutant and human alike! Karai returns to New York and the future of the TMNT, and all of NYC, comes down to a final negotiation between Splinter and Karai. Can they reach an agreement before Bishop's new plan begins? Leonardo, Raphael, Donatello, and Michelangelo face a gauntlet of danger unlike anything they have experienced before! Collects issues #90-95 of the ongoing series.