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Author: Wei Shi Publisher: ISBN: Category : Acoustic imaging Languages : en Pages : 142
Book Description
Tumor metastasis is referred to the spread of cancer from one to another unadjacent part of the body, which results in more than 90% of tumor deaths, and however is still poorly understood. Circulating tumor cells (CTCs) have been proposed as an important biomarker of tumor metastasis. Many approaches have been developed for detection of CTCs, but each has its own advantages and disadvantages. With the aid of nanoparticles (NPs), photoacoustic detection along with efficient magnetic enrichment of CTCs demonstrated high sensitivity. However, differentiation of photoacoustic signals is non-trivial hence specificity can be poor. Surface-enhanced-Raman-scattering (SERS) NPs were used for detection of CTCs with high multiplexing capability. However, the lack of enrichment of CTCs limits its application for in vivo detection. High sensitivity and high specificity in vivo methods of detecting CTCs are in urgent need. A hallmark signature of metastasis is angiogenesis, the proliferation of vessel networks growing from pre-existing vasculature. Imaging angiogenesis is important for cancer research since angiogenesis is regarded as a necessity for tumor growth and tumor metastasis. Photoacoustic imaging (PAM) is a promising technique for imaging angiogenesis due to intrinsic high optical contrast between blood and tissues, and high spatial resolution at adequate penetration depth. Optical-resolution photoacoustic imaging (OR-PAM) pushed the lateral resolution limit of PAM to micron or submicron level, which enables imaging of single capillaries, the finest vasculature elements. However, the low imaging speed of OR-PAM may limit its application in the clinic, and for practical pre-clinical imaging of animal models. A single modality tool for studies on tumor metastasis is unlikely to be able to fullfill these needs. Therefore, the long term goal of this dissertation is to develop a multimodality imaging tool for imaging tumor metastasis and detecting of CTCs with high specificity and high sensitivity. Specially, we focused on the approach of combing PAM with a Raman imaging technology for this purpose. For the task of detecting CTCs, the photoacoustic subsystem could aid in placement of a magnet for trapping of such CTCs and gaging the flow rate for optimal optical and multiplexed detection with the Raman sub-system. The photoacoustic sub-system could also be used for detecting absorption signatures from nanoparticles on tumor cells. For detecting metastases, the Raman imaging subsystem could be used to detect multiple flavors of nanoparticles targeted to (non-circulating) tumor cells and the photoacoustic sub-system could be used to detect neoplasm angiogenesis. We aimed to push limits of OR-PAM imaging frame-rate, to develop a novel CTC detection technique with high sensitivity and high specificity, and to further build a multimodality photoacoustic-Raman imaging tool for high sensitivity and high specificity molecular imaging. Our work presented in this dissertation can be divided into three parts. First, we worked on developing realtime OR-PAM using various high pulse repetition rate lasers and combined with a fast optical scanning galvanometer mirror systems. We reported the first near realtime volumetric OR-PAM with 4 frames per second (fps) imaging speed and ~ 6 ?m lateral resolution by employing a fiber laser with up to 600 kHz pulse repetition rate. Further, we demonstrated in vivo near realtime sustained OR-PAM imaging of dynamic process and 30 fps realtime imaging of cardiac-induced mircrohemodynamics in murine microvasculature. In addition, we studied the scanning speed dependence of photoacoustic signals which may lead to a super-resolution technique in the future. Second, we demonstrated for the first time the magnetic enrichment and detection of CTCs in circulating PBS or rat blood with high specificity and high sensitivity by targeting tumor cells with both SERS NPs and magnetic NPs (MNPs). Third, we presented a multimodality imaging system consisting of PAM and SERS imaging which may advance the research of tumor metastasis in the future.
Author: Wei Shi Publisher: ISBN: Category : Acoustic imaging Languages : en Pages : 142
Book Description
Tumor metastasis is referred to the spread of cancer from one to another unadjacent part of the body, which results in more than 90% of tumor deaths, and however is still poorly understood. Circulating tumor cells (CTCs) have been proposed as an important biomarker of tumor metastasis. Many approaches have been developed for detection of CTCs, but each has its own advantages and disadvantages. With the aid of nanoparticles (NPs), photoacoustic detection along with efficient magnetic enrichment of CTCs demonstrated high sensitivity. However, differentiation of photoacoustic signals is non-trivial hence specificity can be poor. Surface-enhanced-Raman-scattering (SERS) NPs were used for detection of CTCs with high multiplexing capability. However, the lack of enrichment of CTCs limits its application for in vivo detection. High sensitivity and high specificity in vivo methods of detecting CTCs are in urgent need. A hallmark signature of metastasis is angiogenesis, the proliferation of vessel networks growing from pre-existing vasculature. Imaging angiogenesis is important for cancer research since angiogenesis is regarded as a necessity for tumor growth and tumor metastasis. Photoacoustic imaging (PAM) is a promising technique for imaging angiogenesis due to intrinsic high optical contrast between blood and tissues, and high spatial resolution at adequate penetration depth. Optical-resolution photoacoustic imaging (OR-PAM) pushed the lateral resolution limit of PAM to micron or submicron level, which enables imaging of single capillaries, the finest vasculature elements. However, the low imaging speed of OR-PAM may limit its application in the clinic, and for practical pre-clinical imaging of animal models. A single modality tool for studies on tumor metastasis is unlikely to be able to fullfill these needs. Therefore, the long term goal of this dissertation is to develop a multimodality imaging tool for imaging tumor metastasis and detecting of CTCs with high specificity and high sensitivity. Specially, we focused on the approach of combing PAM with a Raman imaging technology for this purpose. For the task of detecting CTCs, the photoacoustic subsystem could aid in placement of a magnet for trapping of such CTCs and gaging the flow rate for optimal optical and multiplexed detection with the Raman sub-system. The photoacoustic sub-system could also be used for detecting absorption signatures from nanoparticles on tumor cells. For detecting metastases, the Raman imaging subsystem could be used to detect multiple flavors of nanoparticles targeted to (non-circulating) tumor cells and the photoacoustic sub-system could be used to detect neoplasm angiogenesis. We aimed to push limits of OR-PAM imaging frame-rate, to develop a novel CTC detection technique with high sensitivity and high specificity, and to further build a multimodality photoacoustic-Raman imaging tool for high sensitivity and high specificity molecular imaging. Our work presented in this dissertation can be divided into three parts. First, we worked on developing realtime OR-PAM using various high pulse repetition rate lasers and combined with a fast optical scanning galvanometer mirror systems. We reported the first near realtime volumetric OR-PAM with 4 frames per second (fps) imaging speed and ~ 6 ?m lateral resolution by employing a fiber laser with up to 600 kHz pulse repetition rate. Further, we demonstrated in vivo near realtime sustained OR-PAM imaging of dynamic process and 30 fps realtime imaging of cardiac-induced mircrohemodynamics in murine microvasculature. In addition, we studied the scanning speed dependence of photoacoustic signals which may lead to a super-resolution technique in the future. Second, we demonstrated for the first time the magnetic enrichment and detection of CTCs in circulating PBS or rat blood with high specificity and high sensitivity by targeting tumor cells with both SERS NPs and magnetic NPs (MNPs). Third, we presented a multimodality imaging system consisting of PAM and SERS imaging which may advance the research of tumor metastasis in the future.
Author: Arnaud Zoubir Publisher: Springer ISBN: 3642282520 Category : Science Languages : en Pages : 388
Book Description
Raman imaging has long been used to probe the chemical nature of a sample, providing information on molecular orientation, symmetry and structure with sub-micron spatial resolution. Recent technical developments have pushed the limits of micro-Raman microscopy, enabling the acquisition of Raman spectra with unprecedented speed, and opening a pathway to fast chemical imaging for many applications from material science and semiconductors to pharmaceutical drug development and cell biology, and even art and forensic science. The promise of tip-enhanced raman spectroscopy (TERS) and near-field techniques is pushing the envelope even further by breaking the limit of diffraction and enabling nano-Raman microscopy.
Author: Fred S. Azar Publisher: Artech House ISBN: 1596933089 Category : Medical Languages : en Pages : 431
Book Description
Supported with 119 illustrations, this milestone work discusses key optical imaging techniques in self-contained chapters; describes the integration of optical imaging techniques with other modalities like MRI, X-ray imaging, and PET imaging; provides a software platform for multimodal integration; presents cutting-edge computational and data processing techniques that ensure rapid, cost-effective, and precise quantification and characterization of the clinical data; covers advances in photodynamic therapy and molecular imaging, and reviews key clinical studies in optical imaging along with regulatory and business issues.
Author: Surya N. Thakur Publisher: Elsevier ISBN: 0323972012 Category : Science Languages : en Pages : 692
Book Description
Photoacoustic and Photothermal Spectroscopy: Principles and Applications introduces the basic principles, instrumentation and major developments in the many applications of Photoacoustic and Photothermal Spectroscopy over the last three decades. The book explains the processes of sound generation by periodic optical excitation and ultrasonic generation by pulsed laser excitation and describes the workings of photoacoustic cells equipped with microphones and piezoelectric transducers. Photoacoustic imaging (PAI) is one of the fastest-growing imaging modalities of recent times. It combines the advantages of ultrasound and optical imaging techniques. These non-invasive and non-destructive techniques offer many benefits to users by enabling spectroscopy of opaque and inhomogeneous materials, (solid, liquid, powder, gel, gases) without any sample preparation, and more. - Written in a non-mathematical, simple-to-read manner - Presents recent developments in the field, along with the scope of future progress, including up-to-date references - Includes detailed illustrations, such as equipment layout, spectra, experimental setups, tables, photographs, and more
Author: Yuen Y. Hui Publisher: John Wiley & Sons ISBN: 111937345X Category : Technology & Engineering Languages : en Pages : 407
Book Description
A comprehensive reference on biochemistry, bioimaging, bioanalysis, and therapeutic applications of carbon nanomaterials Carbon nanomaterials have been widely applied for biomedical applications in the past few decades, because of their unique physical properties, versatile functionalization chemistry, and biological compatibility. This book provides background knowledge at the entry level into the biomedical applications of carbon nanomaterials, focusing on three applications: bioimaging, bioanalysis, and therapy. Carbon Nanomaterials for Bioimaging, Bioanalysis and Therapy begins with a general introduction to carbon nanomaterials for biomedical applications, including a discussion about the pros and cons of various carbon nanomaterials for the respective therapeutic applications. It then goes on to cover fluorescence imaging; deep tissue imaging; photoacoustic imaging; pre-clinical/clinical bioimaging applications; carbon nanomaterial sensors for cancer and disease diagnosis; targeted cancer therapy; and photothermal/photodynamic therapy. Each chapter briefly introduces the biomedical application and emphasizes the most appropriate carbon nanomaterial(s) for the application. Provides an introduction to the biomedical applications of carbon nanomaterials for early-career scientists, as well as background and context for mid-career scientists and researchers Contains four sections covering biochemistry, bioimaging, bioanalysis, and therapeutic applications of carbon nanomaterials Presented by experts who have strong background in the field of nanotechnology for biomedical applications Covers a hot area of research which has very unique physical properties, versatile functionalization chemistry, and biological compatibility Carbon Nanomaterials for Bioimaging, Bioanalysis and Therapy is an excellent resource for academic researchers and industrial scientists working on preparation and bio-application of carbon nanomaterials, biomedical engineering, and nanotechnology.
Author: Yi-Hwa Liu Publisher: CRC Press ISBN: 1466595388 Category : Medical Languages : en Pages : 454
Book Description
This comprehensive book focuses on multimodality imaging technology, including overviews of the instruments and methods followed by practical case studies that highlight use in the detection and treatment of cardiovascular diseases. Chapters cover PET-CT, SPECT-CT, SPECT-MRI, PET-MRI, PET-optical imaging, SPECT-optical imaging, photoacoustic Imaging, and hybrid intravascular imaging. It also addresses the important issues of multimodality imaging probes and image quantification. Readers from radiology and cardiology as well as medical imaging and biomedical engineering will learn essentials of the field. They will be shown how the field has advanced quantitative analysis of molecularly targeted imaging through improvements in the reliability and reproducibility of imaging data. Moreover, they will be presented with quantification algorithms and case illustrations, including coverage of such topics such as multimodality image fusion and kinetic modeling. Yi-Hwa Liu, PhD is Senior Research Scientist in Cardiovascular Medicine at Yale University School of Medicine and Technical Director of Nuclear Cardiology at Yale New Haven Hospital. He is also an Associate Professor (Adjunct) of Biomedical Imaging and Radiological Sciences at National Yang-Ming University, Taipei, Taiwan, and Professor (Adjunct) of Biomedical Engineering at Chung Yuan Christian University, Taoyuan, Taiwan. He is an elected senior member of Institute of Electrical and Electronic Engineers (IEEE) and a full member of Sigma Xi of The Scientific Research Society of North America. Albert J. Sinusas, M.D., FACC, FAHA is Professor of Medicine (Section of Cardiovascular Medicine) and Radiology and Biomedical Imaging, at Yale University School of Medicine, and Director of the Yale Translational Research Imaging Center (Y-TRIC), and Director of Advanced Cardiovascular Imaging at Yale New Haven Hospital. He is a recipient of the Society of Nuclear Medicine’s Hermann Blumgart Award.
Author: Mithun Kuniyil Ajith Singh Publisher: Springer Nature ISBN: 9811539847 Category : Science Languages : en Pages : 393
Book Description
This book highlights the use of LEDs in biomedical photoacoustic imaging. In chapters written by key opinion leaders in the field, it covers a broad range of topics, including fundamentals, principles, instrumentation, image reconstruction and data/image processing methods, preclinical and clinical applications of LED-based photoacoustic imaging. Apart from preclinical imaging studies and early clinical pilot studies using LED-based photoacoustics, the book includes a chapter exploring the opportunities and challenges of clinical translation from an industry perspective. Given its scope, the book will appeal to scientists and engineers in academia and industry, as well as medical experts interested in the clinical applications of photoacoustic imaging.
Author: Michael R. Hamblin Publisher: Elsevier ISBN: 1908818786 Category : Science Languages : en Pages : 573
Book Description
Nanoscience has become one of the key growth areas in recent years. It can be integrated into imaging and therapy to increase the potential for novel applications in the field of photomedicine. In the past commercial applications of nanoscience have been limited to materials science research only, however, in recent years nanoparticles are rapidly being incorporated into industrial and consumer products. This is mainly due to the expansion of biomedical related research and the burgeoning field of nanomedicine. Applications of Nanoscience in Photomedicine covers a wide range of nanomaterials including nanoparticles used for drug delivery and other emerging fields such as optofluidics, imaging and SERS diagnostics. Introductory chapters are followed by a section largely concerned with imaging, and finally a section on nanoscience-enabled therapeutics. - Covers a comprehensive up-to-date information on nanoscience - Focuses on the combination of photomedicine with nanotechnology to enhance the diversity of applications - Pioneers in the field have written their respective chapters - Opens a plethora of possibilities for developing future nanomedicine - Easy to understand and yet intensive coverage chapter by chapter
Author: Ahmed Barhoum Publisher: Springer Nature ISBN: 3031321502 Category : Science Languages : en Pages : 2831
Book Description
This book highlights all newly reported carbon nanostructures including graphene and its derivatives, carbon nanotubes, metal organic frameworks, fullerenes, nanorods, nanospheres, nano onions, porous nanoparticles, nanohorns, nanofibers and nanoribbons, nanodiamonds, graphitic carbon nitrides, carbon aerogels and hydrogels, graphdiyne and graphenylene. It presents the historical development of carbon nanostructures technologies, different types and classifications, and different fabrication and functionalization techniques, including outer/inner surface functionalization and covalent and noncovalent functionalization. This Handbook discusses the unique properties of functionalized carbon nanostructures that can be obtained by modifying their structures, composition, and surface. It gives the reader an in-depth look at the current achievements of research and practice while pointing you ahead to new possibilities in functionalizing and using carbon nanomaterials. Finally, it covers the various applications of functionalized carbon nanostructures including adsorbents, additives, active materials in energy accumulating systems (batteries, hydrogen storage systems, and supercapacitors), filtering media, catalysts or supports for catalysts, sensors or substrates for sensors, additives for polymers, ceramic composites, metal and carbon alloys, glasses, digital textiles, and composite materials.
Author: Wei Shi
Author: Wei Shi
Author: Arnaud Zoubir
Author: Fred S. Azar
Author: Dalong Ni
Author: Surya N. Thakur
Author: Yuen Y. Hui
Author: Yi-Hwa Liu
Author: Mithun Kuniyil Ajith Singh
Author: Michael R. Hamblin
Author: Ahmed Barhoum