Mouse Models of B Cell Malignancies PDF Download

Author: Gema Perez-Chacon
Publisher: Frontiers Media SA
ISBN: 2889718964
Category : Medical
Languages : en
Pages : 202

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Author: Shaoguang Li
Publisher: Springer Science & Business Media
ISBN: 0387691324
Category : Medical
Languages : en
Pages : 298

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Book Description
In this book, Dr. Li and his author team plan to emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The authors do not intend to cover all types of blood cancers; instead, they will focus on some major ones such as leukemias and lymphomas. However, the authors will try to cover as much as they can the cancer types and point out that many blood cancers need to be studied in mouse disease models although they are still not available at present. A major focus in the book will be to show what we can or cannot learn from mouse disease models and to also show the critical contributions of mouse models in therapeutic drug development.

Author: María José Moreno Jiménez
Publisher:
ISBN:
Category :
Languages : en
Pages : 258

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Author: Eric C. Holland
Publisher: John Wiley & Sons
ISBN: 047144460X
Category : Science
Languages : en
Pages : 504

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Book Description
Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

Author: Marten H. Hofker
Publisher: Springer Science & Business Media
ISBN: 1592593402
Category : Science
Languages : en
Pages : 382

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Book Description
Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.

Author: Samuel Robert Lifton
Publisher:
ISBN:
Category : Cancer genes
Languages : en
Pages : 83

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Book Description
Three potential driver genes were identified by use of retroviral mutagenesis in the newly developed iMyc model of B cell malignancy. To do so, iMyc mice, which bear an inserted copy of c-Myc in the IgH locus, were treated with MOL4070LTR to favor the development of B cell malignancies. After tumor development, B cell origin tumors were identified by use of immunohistochemistry and selected for downstream analysis. Three genes were chosen as potential driver genes and validated in mouse or human disease as involved in disease or directly in malignancy. These genes are CD82, IRAK2 and DNMT3a.

Author: Dean Walton Felsher
Publisher:
ISBN:
Category :
Languages : en
Pages : 282

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Author: Briana Fitch
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Excessive inflammatory responses to common childhood infections are associated with an increased risk of pediatric B cell Acute Lymphoblastic Leukemia (B ALL). Despite the identification of several neonatal inflammatory markers as B ALL risk factors, the mechanism(s) by which these markers stimulate an excessive immune response leading B ALL remain largely unknown. Here, we demonstrate that IL 10 deficiency, a neonatal risk factor for B ALL, indirectly impairs B lymphopoiesis and increases B cell DNA damage through induction of inflammation in mice. Altered B cell number and DNA damage in Il10-/- mice were associated with a module of 6 pro inflammatory/myeloid associated cytokines (IL-1Îł, IL-6, IL-12p40, IL 13, CCL4/MIP 1Îø, and G CSF). Importantly, inflammation and defects in bone marrow B cells were attenuated by treating pre leukemic Il10-/- Ckdn2a-/- mice with antibiotics that target Helicobacter species. In the TEL AML1 Ckdn2a-/- mouse model of B ALL, decreased levels of IL-10 accelerated B cell neoplasms in a dose dependent manner, and altered the mutational profile of B cell neoplasm to favor C>T and T>C mutations. Infection of Cdkn2a-/- mice to Aspiculuris, a parasite that induces IL-10 production, delayed the development of B cell neoplasms in Cdkn2a-/- mice, demonstrating a novel protective effect of microbial exposure. Our results identify commensal bacteria as modulators of bone marrow B cell responses to IL 10 deficiency, and suggest that microbial dysbiosis underlies the infectious etiology of pediatric B ALL.

Author: Jérôme Paggetti
Publisher: Frontiers Media SA
ISBN: 2889742415
Category : Medical
Languages : en
Pages : 164

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Author: Robert M. Hoffman
Publisher: Springer
ISBN: 3319574248
Category : Medical
Languages : en
Pages : 304

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Book Description
This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems