Motion Compensation for 4D PET/CT PDF Download

Author: Matthijs Ferdinand Kruis
Publisher:
ISBN: 9789462594661
Category :
Languages : en
Pages : 0

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Author: Andrea Martinez-Movilla
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Abstract: Background Patient's breathing affects the quality of chest images acquired with positron emission tomography/computed tomography (PET/CT) studies. Movement correction is required to optimize PET quantification in clinical settings. We present a reproducible methodology to compare the impact of different movement compensation protocols on PET image quality. Static phantom images were set as reference values, and recovery coefficients (RCs) were calculated from motion compensated images for the phantoms in respiratory movement. Image quality was evaluated in terms of: (1) volume accuracy (VA) with the NEMA phantom; (2) concentration accuracy (CA) by six refillable inserts within the electron density CIRS phantom; and (3) spatial resolution (R) with the Jaszczak phantom. Three different respiratory patterns were applied to the phantoms. We developed an open-source package to automatically analyze VA, CA and R. We compared 10 different movement compensation protocols available in the Philips Gemini TF-64 PET/CT (4-, 6-, 8- and 10-time bins, 20%-, 30%-, 40%-window width in Inhale and Exhale). Results The homemade package provided RC values for VA, CA and R of 102 PET images in less than 5 min. Results of the comparison of the 10 different protocols demonstrated the feasibility of the proposed method for quantifying the variations observed qualitatively. Overall, prospective protocols showed better motion compensation than retrospective. The best performance was obtained for the protocol Exhale 30% (0.3 s after maximum Exhale position and window width of 30%) with RCVA=1.6±1.3 , RCCA=0.90±0.09 and RCR=0.6±0.4 . Among retrospective protocols, 8 Phase protocol showed the best performance. Conclusion We provided an open-source package able to automatically evaluate the impact of motion compensation methods on PET image quality. A setup based on commonly available experimental phantoms is recommended. Its application for the comparison of 10 time-based approaches showed that Exhale 30% protocol had the best performance. The proposed framework is not specific to the phantoms and protocols presented on this study

Author: Habib Zaidi
Publisher: Elsevier Health Sciences
ISBN: 1455772208
Category : Medical
Languages : en
Pages : 260

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The complexity of issues associated with gating studies with PET imaging are mostly unknown among practitioners of the field, which is posing a significant danger to those who undergo such studies. This is particularly true for respiratory gating examination. Topics in this issue include both basic and clinical topics, including views from radiation oncology physicians.

Author: Marco Durante
Publisher: Frontiers Media SA
ISBN: 288945391X
Category :
Languages : en
Pages : 650

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High-energy charged particles represent a cutting-edge technique in radiation oncology. Protons and carbon ions are used in several centers all over the world for the treatment of different solid tumors. Typical indications are ocular malignancies, tumors of the base of the skull, hepatocellular carcinomas and various sarcomas. The physical characteristics of the charged particles (Bragg peak) allow sparing of much more normal tissues than it is possible using conventional X-rays, and for this reason all pediatric tumors are considered eligible for protontherapy. Ions heavier than protons also display special radiobiological characteristics, which make them effective against radioresistant and hypoxic tumors. On the other hand, protons and ions with high charge (Z) and energy (HZE particles) represent a major risk for human space exploration. The main late effect of radiation exposure is cancer induction, and at the moment the dose limits for astronauts are based on cancer mortality risk. The Mars Science Laboratory (MSL) measured the dose on the route to Mars and on the planet’s surface, suggesting that a human exploration missions will exceed the radiation risk limits. Notwithstanding many studies on carcinogenesis induced by protons and heavy ions, the risk uncertainty remains very high. In this research topic we aim at gathering the experiences and opinions of scientists dealing with high-energy charged particles either for cancer treatment or for space radiation protection. Clinical results with protons and heavy ions, as well as research in medical physics and pre-clinical radiobiology are reported. In addition, ground-based and spaceflight studies on the effects of space radiation are included in this book. Particularly relevant for space studies are the clinical results on normal tissue complications and second cancers. The eBook nicely demonstrates that particle therapy in oncology and protection of astronauts from space radiation share many common topics, and can learn from each other.

Author: Jerold T. Bushberg
Publisher: Lippincott Williams & Wilkins
ISBN: 1975103246
Category : Medical
Languages : en
Pages : 1688

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Book Description
Widely regarded as the cornerstone text in the field, the successful series of editions continues to follow the tradition of a clear and comprehensive presentation of the physical principles and operational aspects of medical imaging. The Essential Physics of Medical Imaging, 4th Edition, is a coherent and thorough compendium of the fundamental principles of the physics, radiation protection, and radiation biology that underlie the practice and profession of medical imaging. Distinguished scientists and educators from the University of California, Davis, provide up-to-date, readable information on the production, characteristics, and interactions of non-ionizing and ionizing radiation, magnetic fields and ultrasound used in medical imaging and the imaging modalities in which they are used, including radiography, mammography, fluoroscopy, computed tomography, magnetic resonance, ultrasound, and nuclear medicine. This vibrant, full-color text is enhanced by more than 1,000 images, charts, and graphs, including hundreds of new illustrations. This text is a must-have resource for medical imaging professionals, radiology residents who are preparing for Core Exams, and teachers and students in medical physics and biomedical engineering.

Author: Mohammad Dawood
Publisher: CRC Press
ISBN: 1439813019
Category : Medical
Languages : en
Pages : 301

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Written by an interdisciplinary team of medical doctors, computer scientists, physicists, engineers, and mathematicians, Correction Techniques in Emission Tomography presents various correction methods used in emission tomography to generate and enhance images. It discusses the techniques from a computer science, mathematics, and physics viewpoint.

Author: Yuji Kuge
Publisher: Springer
ISBN: 4431558942
Category : Medical
Languages : en
Pages : 328

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Book Description
​This work is devoted to understanding the recent advances in nuclear medicine and molecular imaging technologies along with their application to integrated medical therapy and future drug development. This anthology is based on the international symposium in 2015 entitled “Perspective on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. “The symposium provided an opportunity to exchange ideas on how to promote nuclear medicine technology and how to extend the technology to medical therapy and drug development, and was also a good opportunity to discuss the future perspective of nuclear medicine and molecular imaging by worldwide leaders in the field. Molecular imaging technologies have been rapidly developed worldwide in recent years. Among those developments, nuclear medicine has come to play an important role in quantitative analysis of biological process in vivo as well as in wide clinical use. With the current progress of nuclear medicine and molecular imaging, this modality has been applied for treatment monitoring and predicting its outcome with the use of optimal imaging biomarkers and suitable quantitative analysis. Truly, a new era has arrived with clinical use of nuclear medicine and molecular imaging for personalized medicine. This volume will benefit a wide variety of researchers in life science including those working in drug development, molecular imaging, and medical therapy as well as physicians who utilize diagnostic imaging.

Author:
Publisher: ScholarlyEditions
ISBN: 1464964734
Category : Medical
Languages : en
Pages : 1312

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Issues in Cancer Treatment / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer Treatment. The editors have built Issues in Cancer Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer Treatment in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Cancer Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author: Jan Ehrhardt
Publisher: Springer Science & Business Media
ISBN: 3642364411
Category : Science
Languages : en
Pages : 352

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Respiratory motion causes an important uncertainty in radiotherapy planning of the thorax and upper abdomen. The main objective of radiation therapy is to eradicate or shrink tumor cells without damaging the surrounding tissue by delivering a high radiation dose to the tumor region and a dose as low as possible to healthy organ tissues. Meeting this demand remains a challenge especially in case of lung tumors due to breathing-induced tumor and organ motion where motion amplitudes can measure up to several centimeters. Therefore, modeling of respiratory motion has become increasingly important in radiation therapy. With 4D imaging techniques spatiotemporal image sequences can be acquired to investigate dynamic processes in the patient’s body. Furthermore, image registration enables the estimation of the breathing-induced motion and the description of the temporal change in position and shape of the structures of interest by establishing the correspondence between images acquired at different phases of the breathing cycle. In radiation therapy these motion estimations are used to define accurate treatment margins, e.g. to calculate dose distributions and to develop prediction models for gated or robotic radiotherapy. In this book, the increasing role of image registration and motion estimation algorithms for the interpretation of complex 4D medical image sequences is illustrated. Different 4D CT image acquisition techniques and conceptually different motion estimation algorithms are presented. The clinical relevance is demonstrated by means of example applications which are related to the radiation therapy of thoracic and abdominal tumors. The state of the art and perspectives are shown by an insight into the current field of research. The book is addressed to biomedical engineers, medical physicists, researchers and physicians working in the fields of medical image analysis, radiology and radiation therapy.

Author: Vasken Dilsizian
Publisher: John Wiley & Sons
ISBN: 1118754506
Category : Medical
Languages : en
Pages : 482

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Book Description
A complete guide to non-invasive imaging techniques in cardiology Todays imaging technologies offer cardiologists more ways than ever to diagnose conditions of the heart without the need of endoscopies and other invasive procedures. Now in its third edition,Cardiac CT, PET and MRI continues to provide an in-depth explanation of these tools and their correct applications, while also exploring cardiac imagings most recent and groundbreaking developments. This wide-ranging guide places CT, PET and MRI in a practical context, illustrating clearly their respective functions as they apply to specific cardiological disorders and clinical situations. With the addition of seven new chapters, it also offers an expanded insight into PET – an increasingly popular and affordable diagnostic utility, hitherto underexplored in texts devoted to imaging. Cardiac CT, PET and MRI includes: Clinically focused examinations of CT, PET and MRI – the three most popular non-invasive imaging modalities Illustrative full-color photos and images Access to a companion website featuring additional content Cardiologists, radiologists, nuclear medicine physicians, physicists, and imaging technologists alike will find the third edition of Cardiac CT, PET and MRI an informative and accessible resource with a direct use in their day-to-day practice.