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Author: Gerald M. Edelman Publisher: Wiley-Interscience ISBN: Category : Medical Languages : en Pages : 672
Book Description
Presents recent research efforts in the genetic basis of pattern formation and morphogenesis, especially the expression of adhesion molecules. Reviews our understanding of the structure, function, and genetic control of the three families of molecules involved in adhesion: cell adhesion molecules (CAMs), substrate adhesion molecules (SAMs), and cell junctional molecules (CJMs). Covers the biology and chemistry of CAMs, structure and interaction of SAMs, components of junctional complexes, function in histogenesis and disease, and morphology and development.
Author: Gerald M. Edelman Publisher: Wiley-Interscience ISBN: Category : Medical Languages : en Pages : 672
Book Description
Presents recent research efforts in the genetic basis of pattern formation and morphogenesis, especially the expression of adhesion molecules. Reviews our understanding of the structure, function, and genetic control of the three families of molecules involved in adhesion: cell adhesion molecules (CAMs), substrate adhesion molecules (SAMs), and cell junctional molecules (CJMs). Covers the biology and chemistry of CAMs, structure and interaction of SAMs, components of junctional complexes, function in histogenesis and disease, and morphology and development.
Author: Publisher: Academic Press ISBN: 008085771X Category : Psychology Languages : en Pages : 405
Book Description
Selectionism and the Brain addresses a number of important theoretical issues in light of recent empirical data from neuropsychological studies. Edited by two researchers at The Neurosciences Institute, this volume features contributions from such well-known neuroscientists as W. Singer, L.R. Squire, A. Georgopoulos, and O. Sacks. Selectionism and the Brain evaluates selectionist approaches to brain function, including Gerald Edelmans revolutionary theoryof neural Darwinism, and explores how these approaches change the way we look at neurons, neuronal systems, and the brain.
Author: Greg R. Phillips Publisher: ISBN: 9780591581553 Category : Cell adhesion molecules Languages : en Pages : 322
Book Description
Cell-cell and cell-substrate adhesion molecules, CAMs and SAMs, are two classes of morphoregulatory molecules that are important for regulating cellular processes such as cell proliferation, cell migration, cell differentiation, and neurite extension during the development and regeneration of the nervous system. The present study examines the functions of two such molecules, tenascin (TN), a SAM, and the neural cell adhesion molecule (N-CAM), a CAM. TN has a multidomain structure with regions homologous to epidermal growth factor (EGF)-like repeats, fibronectin type III (FNIII) repeats, and fibrinogen (fg). Earlier studies identified cell binding sites within the FNIII repeats and established that the third FNIII repeat interacted with several integrins. In the present study, the FNIII repeat region was further characterized for its ability to support neuron attachment, neurite outgrowth and cell migration. The sixth FNIII repeat was found to support fibroblast and neuronal attachment, and to stimulate neurite outgrowth and glioma cell migration. The binding of fibroblasts and neurons to the sixth FNIII repeat was integrin dependent. The third FNIII repeat also promoted neurite outgrowth and glioma migration. The fifth FNIII repeat supported attachment of glioma cells but not neurons or fibroblasts and inhibited glioma migration. Thus, the involvement of multiple TN domains and the engagement of multiple cellular receptors influences the complex processes of neurite extension and glioma cell migration. N-CAM is an adhesion molecule of the immunoglobulin superfamily and it carries an unusual polysialic acid carbohydrate moiety, the amount of which changes during neural development and regeneration. Polysialylation of N-CAM imparts a negative charge to the cell surface, reducing the strength of cell-cell and cell-matrix interactions. Hamster PST-1 (PST) is a recently cloned sialyltransferase that catalyzes the polysialylation of N-CAM and that displayed homology to a sialyltransferase of unknown specificity, STX. In the present study, a cDNA for rat PST was isolated and both rat PST and rat STX were shown to polysialylate N-CAM at similar levels in transfection studies. The distributions of PST and STX mRNAs were compared with that of polysialic acid and N-CAM at three developmental stages using in situ hybridization and immunohistochemistry. The distribution of both PST and STX mRNAs were consistent with the expression pattern for polysialic acid and suggest that both PST and STX participate in the polysialylation of N-CAM in vivo. The above studies elaborate on the roles of these two molecules in neural development and suggest reagents that may be useful for the study of nerve regeneration.
Author: Publisher: ISBN: Category : Languages : en Pages : 24
Book Description
The hyaluronan binding protein RHAMM is located on the cell surface in the cytoplasm and the nucleus as well as lamellae and in these characteristics resembles the morphogenic branching factor epimorphin. Our goal was the identification and characterization of the interplay between RHAMM and epimorphin during mammary gland morphogenesis and, for the future, breast tumor progression. In order to begin to identify and investigate a function for RHAMM during. epimorphin-regulated mammary gland morphogenesis we analyzed RHAMM expression in virgin and pregnant mice and studied the effect of RHAMM deficiency on in vivo and in vitro branching morphogenesis. RHAMM is expressed by breast epithelial cells, as detected by RT-PCR and western blot analysis and expression increases during pregnancy as shown by RT-%PCR analysis, immuno staining and in situ hybridization. Mammary glands isolated from RHAMM 4- mice show reduced secondary branching compared to mammary glands isolated from wild type (wt) mice. Absence of RHAMM due to genetic deletion or inhibition of RHAMM function by function blocking reagents e.g. antibodies or recombinant protein fragments, leads to enhanced branching in in vitro assays. This difference between in vivo and in vitro results suggests that the in vitro environment might provide factors e.g. growth factors, which are limiting in the in vivo environment, possibly due to the loss of the RHAMM gene. Resurfacing of scratch wounds of breast epithelial cell monolayer is enhanced in the presence of function blocking anti-RHAMM antibodies and regulation of cell motility might be one mechanism by which RHAMM influences branching morphogenesis.
Author: Wanda M. Haschek Publisher: Elsevier ISBN: 0080491448 Category : Medical Languages : en Pages : 2160
Book Description
A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs and chemicals. Toxicologic pathology relies heavily on the fields of both toxicology and pathology, which are well covered individually in various texts and references; however, there are few texts that address the field of toxicologic pathology. The Handbook of Toxicologic Pathology fills this void and is thus essential for all health professionals within or interacting with the field of toxicologic pathology. This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury. Key Features * Easy to find, up-to-date reference information * Graphic and photographic plates * Current hot topics and anticipated changes in toxicologic pathology * Standardized chapter format * Topics that are addressed in both a broad and deep manner, resulting in a stand alone text * Added coverage of important environmental toxicants * Chapters authored by internationally recognized experts and peer-reviewed
Author: Herrick Baltscheffsky Publisher: Cambridge University Press ISBN: 9780521336420 Category : Science Languages : en Pages : 400
Book Description
An interdisciplinary account of the recent advances made in understanding fundamental molecular aspects of the pre-biological and biological evolution of life.
Author: Julius M. Cruse MD PhD Publisher: CRC Press ISBN: 1420039946 Category : Medical Languages : en Pages : 857
Book Description
With more than 1100 computer-generated figures, line drawings, and photographs, Atlas of Immunology clearly demonstrates thata picture is worth a thousand words. Written for students, basic scientists, and clinicians, this second edition provides a thorough and up-to-date treatment of all the concepts needed to comprehend contemporary imm
Author: Gerald M. Edelman
Author: Gerald M. Edelman
Author: Alexander Noveen
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Author: Greg R. Phillips
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Author: Gerald M. Edelman
Author: Kathryn L. Crossin
Author: Wanda M. Haschek
Author: Herrick Baltscheffsky
Author: Julius M. Cruse MD PhD