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Author: Sara Sadeghi Publisher: ISBN: Category : Biopolymers Languages : en Pages : 176
Book Description
Biopolymers are one of the main components of living systems. Their sequence dictates their structure that ultimately determines their function. Many factors play key mechanical roles in the cell and one of the most abundant biopolymers that is involved in such tasks is the class of coiled-coil proteins. Various theoretical and experimental studies have been done to explore the mechanical properties of these proteins and there are now a number of single molecule measurements that measure their force response characteristics, making coiled-coils an excellent model system to test folding models connecting sequence to structure to function. In this thesis we have developed a coarse-grained atomistic model to study coiled-coil formation and explore both mechanical and thermal properties. Our model is able to reproduce known coiled-coil structures using only a simple hydrophobic-polar (HP) representation of their sequence and is able to explain the observed mechanical response measured in single molecule experiments. To address how common coiled-coil formation is with respect to all possible helix packs, we have evaluated the designability of the space of possible helical folds, define d as the number of sequences that can fold into a particular structure. We find that left-handed coils emerge as one of the most highly designable structures. From the designability calculation we can identify sequence patterns that design particular coiled-coil folds and mutations that lead to their instability. We also predict that designable coiled-coil structures are more mechanically stable than less designable helical packs.
Author: Sara Sadeghi Publisher: ISBN: Category : Biopolymers Languages : en Pages : 176
Book Description
Biopolymers are one of the main components of living systems. Their sequence dictates their structure that ultimately determines their function. Many factors play key mechanical roles in the cell and one of the most abundant biopolymers that is involved in such tasks is the class of coiled-coil proteins. Various theoretical and experimental studies have been done to explore the mechanical properties of these proteins and there are now a number of single molecule measurements that measure their force response characteristics, making coiled-coils an excellent model system to test folding models connecting sequence to structure to function. In this thesis we have developed a coarse-grained atomistic model to study coiled-coil formation and explore both mechanical and thermal properties. Our model is able to reproduce known coiled-coil structures using only a simple hydrophobic-polar (HP) representation of their sequence and is able to explain the observed mechanical response measured in single molecule experiments. To address how common coiled-coil formation is with respect to all possible helix packs, we have evaluated the designability of the space of possible helical folds, define d as the number of sequences that can fold into a particular structure. We find that left-handed coils emerge as one of the most highly designable structures. From the designability calculation we can identify sequence patterns that design particular coiled-coil folds and mutations that lead to their instability. We also predict that designable coiled-coil structures are more mechanically stable than less designable helical packs.
Author: Emelio A. Scarpetti Publisher: Nova Publishers ISBN: 9781600215995 Category : Science Languages : en Pages : 358
Book Description
This book presents leading-edge research on colloids and surface science and spans a wide range of topics including biological interactions at surfaces, molecular assembly of selective surfaces, role of surface chemistry in microelectronics and catalysis, tribology, and colloidal physics in the context of crystallisation and suspensions; fluid interfaces; adsorption; surface aspects of catalysis; dispersion preparation, characterisation and stability; aerosols, foams and emulsions; surfaces forces; micelles and microemulsions; light scattering and spectroscopy; nanoparticles; new material science; detergency and wetting; thin films, liquid membranes and bilayers; surfactant science; polymer colloids; rheology of colloidal and disperse systems; electrical phenomena in interfacial and disperse systems.
Author: J. Andrew McCammon Publisher: Cambridge University Press ISBN: 9780521356527 Category : Science Languages : en Pages : 256
Book Description
This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.
Author: Publisher: ScholarlyEditions ISBN: 1464963304 Category : Technology & Engineering Languages : en Pages : 11119
Book Description
Issues in Materials and Manufacturing Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Materials and Manufacturing Research. The editors have built Issues in Materials and Manufacturing Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Materials and Manufacturing Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Materials and Manufacturing Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: S.B. Ross-Murphy Publisher: Springer ISBN: 1461521017 Category : Technology & Engineering Languages : en Pages : 453
Book Description
This preface is very short, not least because an introductory chapter incorporating much of the material of a conventional preface has been included and covers most of the important points in somewhat greater detail than we have scope for here. The reader should consult this as a guide to the structure of this volume, and the purpose it serves. Nevertheless, some general comments are pertinent. At a practical level, some understanding of the properties of food biopolymers is presumably historical, perhaps dating back to the invention of fire, when stone age man first discovered that heating animal carcasses increased their palatability. Indeed, one is reminded of the essay of Charles Lamb in which he claims that roast pork was first discovered by accident, when the pig-sty of an ancient Chinese village was accidentally burnt to the ground, consuming its unfortunate occupants. In the last 20 years, however, substantial scientific advances have been made in this area, by the application of ideas perhaps more common in other areas of macromolecular science to food biopolymer constituents, and this knowledge is now being applied in a non empirical manner to the development of new products. One very successful example of this approach is the work on low-fat 'healthy option' products in which understanding of the thermodynamics, interactions, structure and rheology of mixed protein-polysaccharide gelling systems is being employed. The present volume describes the application of modern macro molecular techniques to the characterisation of food biopolymers.
Author: Sara Sadeghi
Author: Sara Sadeghi
Author: Pamela Ann Mills
Author: O. A. Ogunsola
Author: Emelio A. Scarpetti
Author: J. Andrew McCammon
Author: Lawrence V. Gallacher
Author: 
Author: S.B. Ross-Murphy
Author: Aviva Rice
Author: James Patton Downey