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Author: Ben Martynoga Publisher: Troubador Publishing Ltd ISBN: 1789014271 Category : Science Languages : en Pages : 240
Book Description
Reveals some of the thrilling developments that have transformed biology since the 1960s. Highlights the challenges ahead for biologists but suggests what they can learn from the past. Energetic, jargon-free writing that will appeal to a broad audience. During the 1960s Edinburgh became a hotbed for a forward-thinking group of biologists. This is the story of these innovators who saw that life’s big mysteries were best tackled by studying its molecular foundations. It introduces the eccentric thinkers, ingenious tinkerers and tenacious experimenters who broke down the cultural barriers between traditional scientific disciplines. They produced a series of transformative ideas and tools that wholly reoriented biology. Edinburgh scientists invented genetic engineering. They laid the foundations for DNA fingerprinting and the human genome project. They also cloned Dolly the sheep, purified the first gene and kick-started the now-influential fields of epigenetics and systems biology. Yet Edinburgh’s leading role in most of these world-changing stories have not been told before. Ben Martynoga intertwines science, biography and anecdote to describe the roots and lasting significance of key biological concepts. He describes the crucial micro-details, the blind alleys, botched experiments, and chance encounters to give a rare insight into the way science really progresses. Now, in the 21st century, biology is increasingly a ‘big science’ endeavour. A deeper understanding of biology could deliver not only new drugs and diagnostics, but also improved ways to feed, clothe and fuel us. But the world still awaits the long-promised fruits of biology’s molecular revolution. The successes of Edinburgh’s unsung molecular pioneers remind us why it is crucial to carve out space for small-scale, curiosity-led research.
Author: Ben Martynoga Publisher: Troubador Publishing Ltd ISBN: 1789014271 Category : Science Languages : en Pages : 240
Book Description
Reveals some of the thrilling developments that have transformed biology since the 1960s. Highlights the challenges ahead for biologists but suggests what they can learn from the past. Energetic, jargon-free writing that will appeal to a broad audience. During the 1960s Edinburgh became a hotbed for a forward-thinking group of biologists. This is the story of these innovators who saw that life’s big mysteries were best tackled by studying its molecular foundations. It introduces the eccentric thinkers, ingenious tinkerers and tenacious experimenters who broke down the cultural barriers between traditional scientific disciplines. They produced a series of transformative ideas and tools that wholly reoriented biology. Edinburgh scientists invented genetic engineering. They laid the foundations for DNA fingerprinting and the human genome project. They also cloned Dolly the sheep, purified the first gene and kick-started the now-influential fields of epigenetics and systems biology. Yet Edinburgh’s leading role in most of these world-changing stories have not been told before. Ben Martynoga intertwines science, biography and anecdote to describe the roots and lasting significance of key biological concepts. He describes the crucial micro-details, the blind alleys, botched experiments, and chance encounters to give a rare insight into the way science really progresses. Now, in the 21st century, biology is increasingly a ‘big science’ endeavour. A deeper understanding of biology could deliver not only new drugs and diagnostics, but also improved ways to feed, clothe and fuel us. But the world still awaits the long-promised fruits of biology’s molecular revolution. The successes of Edinburgh’s unsung molecular pioneers remind us why it is crucial to carve out space for small-scale, curiosity-led research.
Author: Isaac Ishaaya Publisher: Springer Science & Business Media ISBN: 9400744978 Category : Science Languages : en Pages : 331
Book Description
Among the highlights of this book is the use of novel insecticides acting on a specific site in an insect group and are compatible with natural enemies and the environment. One of such approaches is based on disrupting the activity of biochemical sites acting on transcription factors such as the Helix-Loop-Helix (bHLH) family, anti juvenile hormone (AJH) agents that target JH biosynthetic enzymes, G-protein coupled receptors (GPCR) and bursicon as a target for insect control. Another one is the biotechnology or the genetic approach such as gene silencing (RNA interference) and Bt-crops. Other sections of the book are devoted to the plant’s natural products, optical manipulation and the use of nanotechnology for improving insect control methods.
Author: Deniz Ekinci Publisher: BoD – Books on Demand ISBN: 9535100491 Category : Science Languages : en Pages : 448
Book Description
Chemical biology utilizes chemical principles to modulate systems to either investigate the underlying biology or create new function. Over recent years, chemical biology has received particular attention of many scientists in the life sciences from botany to medicine. This book contains an overview focusing on the research area of protein purification, enzymology, vitamins, antioxidants, biotransformation, gene delivery, signaling, regulation and organization. Particular emphasis is devoted to both theoretical and experimental aspects. The textbook is written by international scientists with expertise in synthetic chemistry, protein biochemistry, enzymology, molecular biology, drug discovery and genetics many of which are active chemical, biochemical and biomedical research. The textbook is expected to enhance the knowledge of scientists in the complexities of chemical and biological approaches and stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications of chemical biology.
Author: Valentin Gordeliy Publisher: Springer Nature ISBN: 107162329X Category : Science Languages : en Pages : 371
Book Description
This volume provides readers with the latest information on the advances made in the field of rhodopsins. The chapters in this book cover topics such as new discoveries and developments; new ways to search for rhodopsins; methods to characterize the function and structure of rhodopsins on a molecular level; nano volume high throughput in meso crystallization, and fourth generation x-ray synchrotron sources. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Rhodopsin: Methods and Protocols is a valuable resource for any scientist and researcher interested in learning more about this developing field.
Author: Sabine Begall Publisher: Springer Science & Business Media ISBN: 3540692762 Category : Science Languages : en Pages : 392
Book Description
Subterranean Rodents presents achievements from recent years of research on these rodents, divided into five sections: ecophysiology; sensory ecology; life histories, behavioural ecology and demography; environmental and economical impact; molecular ecology and evolution. It is a must for all researchers working in this field and will be of interest to zoologists, physiologists, morphologists, ecologists, and evolutionary biologists.
Author: Spencer Scoular Publisher: Createspace Independent Publishing Platform ISBN: 1490548343 Category : Science Languages : en Pages : 329
Book Description
Albert Einstein once wrote: "The supreme task of the physicist is to arrive at those universal laws from which the cosmos can be built up by pure deduction." Remarkably, in this book we arrive at those universal axioms from which universal science can be built up by pure deduction. Within the prevailing paradigm of science - the mathematical philosophy of nature - we show it is not possible to unify science. To overcome this limitation we introduce a new, more general paradigm. Since the new paradigm is a generalisation of the mathematical philosophy of nature, we are able to retain the mathematical knowledge built up within the prevailing paradigm. Within the new paradigm we introduce four empirical universal axioms, from which we deduce that it is not possible to mathematically unify the two fundamental theories of physics - quantum theory and general relativity. Instead, from the universal axioms we logically deduce the first symmetry of nature, the first invariance of nature, the universal arrow of time, the universal laws of nature, and the three universal dynamic theories of nature - quantum theory, general relativity and universal evolution. The first symmetry of nature and first invariance of nature arise from the constancy of the universal laws of nature not only being a symmetry, but a unifying symmetry. The biological view of universal evolution provides a new theory of biological evolution that replaces what we show is the deficient neo-Darwinian synthesis. In a similar way, theories of evolution in all the sciences are based on their respective views of universal evolution. From the universal axioms, we deduce the universal features of nature thereby unifying physics, chemistry, biology, psychology, sociology, economics and all of science. This book is written for scientifically-inclined general readers, teachers, students, scientists, philosophers, physicists, chemists, biologists, psychologists, sociologists, and economists.
Author: Publisher: Academic Press ISBN: 0123918723 Category : Science Languages : en Pages : 451
Book Description
This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers G protein coupled receptors - Contains chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain
Author: Gernot Riedel Publisher: Springer Science & Business Media ISBN: 9780306478628 Category : Medical Languages : en Pages : 646
Book Description
The decade of the brain has brought us a few steps closer to some of the key questions in neuroscience. The complexity of memory is seen on the systems and cellular level, and different types of memory are implemented in several cellular changes that can interact, or work independently. From Messengers to Molecules: Memories are Made of These, follows the arguments from different research teams for their particular area of expertise. All chapters are written to stand-alone and provide an up-to-date introduction to the topic for both specialists and novices alike. As a result, a comprehensive compendium covering cellular mechanisms contributing to memory formation in an unusual breadth has emerged. This books will be of interest to researchers working on the pharmacology, physiology and genetics of memory formation, clinicians memory disorders, industry and students in advanced courses in Neuroscience or Pharmacology.
Author: Ernesto Di Mauro Publisher: John Wiley & Sons ISBN: 1789451655 Category : Science Languages : en Pages : 276
Book Description
Origin of Life studies have a nearly-impossible goal: understanding nature through the comprehension of its origins and its complexities. As a growing field with poorly-defined borders, Origin of Life studies profit from progress in other disciplines. This book proposes both an overview of this large area and an in-depth look at the opinions and results obtained by some of the active contributors of this fascinating and deeply thought-provoking matter. The topics are presented in a bottom-up order, first touching on the habitability of the universe, then the rationale behind meaningful prebiotic chemistry, the possible or probable prebiotic chemical frames, the problem of chirality, and moving on through the role of minerals in biogenesis, biogenic fertile environments, the in-and-out problem as solved by vesicles physics, the evolution of the codes, the structure of LUCA and its proto metabolisms and the meaning of complex extant biological biomorphs, as exemplified by viroids. These topics and the reasoning within the chapters are provided against the backdrop of the evolution of information and complexity.
Author: Ben Martynoga
Author: Ben Martynoga
Author: Isaac Ishaaya
Author: Deniz Ekinci
Author: Valentin Gordeliy
Author: Sabine Begall
Author: P. Narayanan
Author: Spencer Scoular
Author: 
Author: Gernot Riedel
Author: Ernesto Di Mauro