Molecular Pathology of Gastroenterological Cancer PDF Download

Author: Eiichi Tahara
Publisher: Springer Science & Business Media
ISBN: 4431659153
Category : Medical
Languages : en
Pages : 360

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Book Description
Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop me nt and progression of esophageal, gastric, and colon cancer require mul tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi cal Association Clinical Laboratory since August 1993.

Author: Antonia R. Sepulveda
Publisher: Springer Science & Business Media
ISBN: 1461460158
Category : Medical
Languages : en
Pages : 276

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Book Description
Molecular Pathology of Neoplastic Gastrointestinal Diseases reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on: the molecular basis of the individual disease molecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapies recommended guidelines for clinical application of molecular tests are included whenever available molecular testing for hereditary predisposition or disease risk animal models and cell culture models of disease

Author: Wataru Yasui
Publisher:
ISBN: 9783805598835
Category : Medical
Languages : en
Pages : 0

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Book Description
The highest rates of gastric cancer are observed in eastern Asia, South America and eastern Europe. More than half of all cases worldwide occur in eastern Asia. Distinguished experts in Asia have reviewed current topics and future perspectives for gastric cancer treatment in molecular pathology, tissue engineering, surgery and chemotherapy. Advances in diagnosis and treatment offer excellent long-term survival rates in the case of early cancer diagnosis, but the prognosis of advanced cancer still remains poor. A detailed understanding of molecular pathogenesis and the individual characteristics of gastric cancer and the development of new medical technologies and therapeutic agents help to provide personalized cancer care for patients of early and advanced cancer. For ongoing success, interactions and developments between bench and bedside as well as clinics and bench are crucial. This special issue is recommended for researchers, pathologists, surgeons, physicians and oncologists in the field of gastroenterology, who are interested in the current topics and future perspectives of molecular pathology, tissue engineering, surgery and chemotherapy of gastric cancer.

Author: Kevin M. Haigis, Ph.D.
Publisher: Springer Science & Business Media
ISBN: 146148412X
Category : Medical
Languages : en
Pages : 319

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Book Description
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.

Author: Chen Liu
Publisher: Springer
ISBN: 331968082X
Category : Medical
Languages : en
Pages : 274

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Book Description
This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available knowledge, the book also discusses the future development of a precision and personalized medicine approach for HCC. Written by experts in the field, Precision Molecular Pathology of Liver Cancer is a concise yet comprehensive resource for practitioners who treat patients with hepatocellular carcinoma.

Author: Laura W. Lamps, MD
Publisher: Springer Publishing Company
ISBN: 1617051217
Category : Medical
Languages : en
Pages : 408

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Book Description
This concisely written, abundantly illustrated guide to a wide range of topics in gastrointestinal neoplasia facilitates the evaluation and accurate diagnosis of gastrointestinal neoplasms, both straightforward and challenging. This approachable guide covers the entire tubular GI tract and features more than 600 high quality images. Written and arranged with the busy practicing pathologist in mind, this practical guide includes, for each entity, definitions and terminology, gross and morphologic features, differential diagnoses, useful ancillary tests, staging and grading parameters, and clinical considerations. Beautiful color figures throughout the volume highlight essential histologic features as well as differential diagnoses and potential diagnostic pitfalls. The book is organized into six introductory chapters focused on approaches to neoplasia, followed by 6 organ-specific chapters covering each segment of the GI tract. The final two chapters offer an in-depth discussion of immunohistochemistry and molecular pathology of gastrointestinal neoplasia. This book is a vital reference for practicing pathologists, and with its clear, concise presentation it is also an excellent resource for pathologists in training. Key Features: Provides clear, concise coverage of neoplastic disease across the entire tubular gastrointestinal tract Offers over 600 high-quality images highlighting key differential points and potentially misleading variants Comprehensive tables cover diagnostic features, tumor types, and other crucial data for pathologists About the Authors: Laura W. Lamps, MD, is Professor and Vice-Chair for Academic Affairs, Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR Andrew M Bellizzi, MD, is Clinical Associate Professor, Department of Pathology, University of Iowa Hospitals and Clinics, University of Iowa Carver College of Medicine; Co-Director of Immunopathology Laboratory and Co-Director of GI Pathology, Holden Comprehensive Cancer Center, Iowa City, IA

Author: James L. Abbruzzese
Publisher:
ISBN: 0195133722
Category : Medical
Languages : en
Pages : 938

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Book Description
In 74 chapters, Gastrointestinal Oncology brings together a diverse group of specialists to provide the most authoritative, up-to-date and encyclopedic volume currently available on the subject. The first part of this text introduces a series of concepts and topics taht are important to gastrointestinal malignancies in general. These topics include epidemiologic principles, prevention, screening, familial GI cancers, developmental and molecular biology, pathobiology, general therapeutic principles, emerging therapies, and palliative care. The second part of the book covers each of the specific cancers affecting the human gastrointestinal tract. These chapters are introduced by state of the art discussions outlining our current understanding of the pathobiology and molecular biology relevant to each cancer. Subsequent sections describe the multidisciplinary management of specific clinical situations. By organizing the treatment-related chapters around clinical scenarios, the reader will readily find the information necessary to effectively manage the complex clinical situations encountered by patients with gastrointestinal malignancies.

Author: Vincenzo Canzonieri
Publisher: Springer
ISBN: 3030048616
Category : Medical
Languages : en
Pages : 256

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Book Description
Gastric cancer is one of the most common and potentially lethal gastrointestinal malignancy, but it is now at the forefront of modern oncology due to new discoveries. In recent years, the field of gastric cancer has been transformed by many notable developments in both the diagnostic area and the therapeutic strategies. The main aim of the text is to propose a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for oncologists, pathologists, surgeons and researchers with an interest in gastric cancer. The first chapters will review the interplay between pathogens and especially H. pylori, inflammation, genomic instability, and tumorigenesis. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspectives will be illustrated. Two specific chapters will deal with tissue and serum biomarkers with an important role in diagnosis as well as prognostic and predictive markers of response to specific therapy. A central section of the book will focus on treatment options available today for patients. Surgery is the cornerstone of treatment for gastric cancer; however, the prognosis of patients with locally advanced disease is still poor even after curative resection. Therefore, in order to improve the prognosis of patients, especially with advanced stage, a multimodal strategy is advisable and is thoroughly addressed in the appropriate section. With the advent of next-generation sequencing and new preclinical model technologies, the genomic landscape of gastric cancer has been delineated and molecular characterizations finalized to novel therapeutic targets of each molecular subtype have been identified. These advances are making it feasible to integrate clinical and phenotype-based diagnostic and therapeutic methods and are described in a dedicated section. The text will conclude with chapters focusing on the future direction of gastric cancer research in the precision medicine era: an in-depth analysis of non-coding RNAs and their role in gastric cancer, the impact of immunomodulation/immunotherapy and the perspectives of nano-medicine will be finally proposed to the audience. A brief review of the existing literature addressing the above mentioned topics will be present in each chapter. This text will serve as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Author: Gyula Mozsik
Publisher: IntechOpen
ISBN: 9789535109075
Category : Medical
Languages : en
Pages : 276

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Book Description
Gastritis, as a medical term, exists for the last 150 years, however, terminology and etiology (including the prognosis ) has changed. Gastritis related medical problems are in the focus of different sub-disciplines: internists , gastroenterologists, pathologists, immunologists, bacteriologists, genetics, biologists etc. After the publications by Marshall and Warren most of the clinicians accepted only the etiopathological role of Helicobacter pylori in the development of gastric and duodenal ulcer , as well as in the gastric cancer. This book presents chapters abou the history of gastritis terminology, animal models, epidemiology, new gastric mucosal endogenous defensive neural mechanism (capsaicin-sinsitive afferentation), different research and clinical methods applied to the background studies and the molecular pathology, biochemistry and genetics involved in the pathways from Helicobacter pylori infection to development of gastric cancer. Intended audience of this book are internists, gastroenterologists, pathologists, bacteriologists, pharmacologists, genetics, biologists , immunologists and other interested researchers.

Author: F. T. Bosman
Publisher: International Agency for Research on Cancer
ISBN:
Category : Medical
Languages : en
Pages : 424

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Book Description
"The WHO Classification of Tumours of the Digestive System presented in this book reflects the views of a Working Group that convened for an Editorial and Consensus Conference at the International Agency for Research on Cancer (IARC), Lyon, December 10-12, 2009"--P. [5].