Molecular Mechanisms Underlying Proteinuria: a TR(i)P Into the Podocyte PDF Download
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Author: David B. Mount Publisher: Elsevier Health Sciences ISBN: 1416002529 Category : Medical Languages : en Pages : 604
Book Description
This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the nephron as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included. Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.
Author: Z.-H. Liui Publisher: Karger Medical and Scientific Publishers ISBN: 3318026514 Category : Science Languages : en Pages : 274
Book Description
The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.
Author: Guillermo Garcia-Garcia Publisher: Academic Press ISBN: 0128043822 Category : Medical Languages : en Pages : 400
Book Description
Chronic Kidney Disease in Disadvantaged Populations investigates the increased incidence and prevalence of kidney disease in vulnerable populations world-wide. The volume explores the complex interactions of genetic, biologic, cultural and socioeconomic factors such as the environment, and specific health behaviors that seem to be responsible for a significant proportion of the health disparities in these communities. Each chapter is written by leading experts in the field and analyzes the prevalence and incidence of pre-dialysis kidney disease in disadvantaged populations across both developed and developing countries. In addition, each contribution analyzes differentiated risk factors and compares the disparities in access to screening, prevention strategies, treatment protocols and renal replacement therapies. Chronic Kidney Disease in Disadvantaged Populations is essential reading for residents, fellows, clinicians and biomedical researchers working in nephrology, internal medicine, and epidemiology, especially those working in areas with high concentrations of disadvantaged populations. Presents a comprehensive account of both traditional and non-traditional risk factors for kidney disease Explores the mechanisms by which poverty increases the burden of kidney disease in these populations, barriers to access to renal health care, including renal replacement therapies, organ donation, and organ commercialization Offers the latest perspectives on outcomes in renal replacement therapies as well as prevention strategies
Author: Lauri Saxen Publisher: Cambridge University Press ISBN: 0521301521 Category : Medical Languages : en Pages : 185
Book Description
Although this description of a model system for cell differentation and organogenesis emphasizes the mammalian kidney, detailed coverage is also given to the development of the transient excretory organs.
Author: Paul L. Kimmel Publisher: Academic Press ISBN: 0128158778 Category : Science Languages : en Pages : 1390
Book Description
Chronic Renal Disease, Second Edition, comprehensively investigates the physiology, pathophysiology, treatment and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD with no coverage of dialysis or transplantation. Chapters are devoted to the scientific investigation of chronic kidney disease, the most common problems faced by nephrologists in the management of chronic kidney disease, specific illnesses in the CKD framework, and how the management of CKD in a polycystic kidney disease patient differs from other CKD patients. This award-winning reference features a series of case studies, covering both clinical aspects and pathophysiology. Questions are open ended, progressively more difficult, and repetitive across different patient clinical problems and different chapters. The cases and questions included will be useful for medical students, residency board reviews, and clinician teaching or conference preparation. Includes case studies and questions which can be used as a teaching tool for medical students and resident Provides coverage of classification and measurement, epidemiology, pathophysiology, complications of CKD, fluid/electrolyte disorders in CKD, CKD and systemic illnesses, clinical considerations, therapeutic considerations, and special considerations
Author: Barbara Lewko Publisher: Frontiers Media SA ISBN: 2889197107 Category : Diabetic nephropathies Languages : en Pages : 98
Book Description
The understanding of the pathogenesis of diabetic nephropathy (DN) has advanced considerably in the last few years. Much has been learned about the natural history, the relative lack of significance of microalbuminuria in reflecting underlying pathological change, questionable effects of ACEs and ARBs on the progression of nephropathy, the emergence of new biomarkers such as Cystatin and the role of cytokines, inflammatory molecules and adhesion molecules. Podocytes, the cells with limited ability to replenish and to repair, play a pivotal role in glomerular filtration. In recent years these cells have become the focus for research on pathogenesis of DN as well as other nephropathies. A recent review from the NIH has identified new insights into the pathophysiology, the genetics and the role of the podocytes and some of the important new metabolic pathways such as mTOR or autophagy which may be targeting the podocyte. Knowledge is emerging about the role of podocyte as a part of immune system and about the role of growth factors and cytokines in regulation of podocyte functions. Presented in this e-book articles highlight recent advances in our understanding of the pathogenesis of kidney pathology and the role of podocytes in this process.
Author: Neil N. Turner Publisher: Oxford University Press ISBN: 0191017655 Category : Medical Languages : en Pages : 3045
Book Description
This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.
Author: National Collaborating Centre for Chronic Conditions (Great Britain) Publisher: Royal College of Physicians ISBN: 1860163408 Category : Medical Languages : en Pages : 238
Book Description
This guideline presents clear criteria for testing of chronic kidney disease, for suspecting progressive CKD and referring people for specialist assessment.