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Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome

Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome PDF Author: Kazunari Kaneko
Publisher: Springer
ISBN: 4431552707
Category : Medical
Languages : en
Pages : 240

Book Description
This comprehensive book reviews our current state of knowledge about the pathogenesis of idiopathic nephrotic syndrome (INS), which comprises a heterogeneous group of diseases with distinct histological characteristics, such as minimal-change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS), and idiopathic membranous nephropathy (IMN). As the word “idiopathic” indicates, the pathogenesis of INS remains unclear. Historically, T-cell dysfunction has been thought to play an important part in the pathogenesis of MCNS, while circulating vascular permeabilities have been believed to induce proteinuria in FSGS. The book further describes recent advances in molecular biology, which have allowed us to speculate on the interactions between visceral glomerular epithelial cells (podocytes) and the relative significance of several molecules in the pathogenesis of INS, such as reactive oxygen species, nuclear factor-kappa B, CD80, angiopoietin-like 4, cardiotrophin-like cytokine-1, and M-type phospholipase A2 receptor. The normally rapid pace of scientific progress occasionally devolves into a state of chaos, and the pathogenetic research on INS is one such case. This volume will help researchers and scientists to collaborate, share resources, and expedite the design of protocols to evaluate the putative factors.

Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome

Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome PDF Author: Kazunari Kaneko
Publisher: Springer
ISBN: 4431552707
Category : Medical
Languages : en
Pages : 240

Book Description
This comprehensive book reviews our current state of knowledge about the pathogenesis of idiopathic nephrotic syndrome (INS), which comprises a heterogeneous group of diseases with distinct histological characteristics, such as minimal-change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS), and idiopathic membranous nephropathy (IMN). As the word “idiopathic” indicates, the pathogenesis of INS remains unclear. Historically, T-cell dysfunction has been thought to play an important part in the pathogenesis of MCNS, while circulating vascular permeabilities have been believed to induce proteinuria in FSGS. The book further describes recent advances in molecular biology, which have allowed us to speculate on the interactions between visceral glomerular epithelial cells (podocytes) and the relative significance of several molecules in the pathogenesis of INS, such as reactive oxygen species, nuclear factor-kappa B, CD80, angiopoietin-like 4, cardiotrophin-like cytokine-1, and M-type phospholipase A2 receptor. The normally rapid pace of scientific progress occasionally devolves into a state of chaos, and the pathogenetic research on INS is one such case. This volume will help researchers and scientists to collaborate, share resources, and expedite the design of protocols to evaluate the putative factors.

Molecular Mechanisms in Chronic Kidney Disease

Molecular Mechanisms in Chronic Kidney Disease PDF Author: Claudia Torino
Publisher: Frontiers Media SA
ISBN: 2889712583
Category : Science
Languages : en
Pages : 282

Book Description


Glomerulonephritis and Nephrotic Syndrome

Glomerulonephritis and Nephrotic Syndrome PDF Author: Thomas Rath
Publisher: BoD – Books on Demand
ISBN: 1789843138
Category : Medical
Languages : en
Pages : 126

Book Description
Chronic kidney disease is a worldwide disease affecting up to 4% of the population. In many cases, glomerulonephritis is the underlying disease leading to kidney failure. One hallmark of glomerulonephritis is proteinuria, which may in its most severe form lead to nephrotic syndrome. In seven chapters, this book puts light on different aspects related to the pathophysiology and clinical aspects of glomerulonephritis. In addition, chapters dealing with the importance of biomarkers in patients with glomerulonephritis will be beneficial for the open-minded reader. Nevertheless, new insights in renal rehabilitation in patients with chronic kidney disease will be provided.

Oxford Textbook of Clinical Nephrology

Oxford Textbook of Clinical Nephrology PDF Author: Neil N. Turner
Publisher: Oxford University Press
ISBN: 0191017655
Category : Medical
Languages : en
Pages : 3045

Book Description
This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.

Encyclopedia of Molecular Mechanisms of Disease

Encyclopedia of Molecular Mechanisms of Disease PDF Author: Florian Lang
Publisher: Springer Science & Business Media
ISBN: 3540671366
Category : Science
Languages : en
Pages : 2348

Book Description
This comprehensive encyclopedia supplies the reader with concise information on the molecular pathophysiology of disease. Entries include defined diseases (such as Parkinson's disease) as well as pathophysiological entities (such as tremor). The 1,200 essays are brilliantly structured to allow rapid retrieval of the desired information. For more detailed reading, each entry is followed by up to five references. Individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved. It is an invaluable companion for clinicians and scientists in all medical disciplines.

Glomerulonephritis

Glomerulonephritis PDF Author: Howard Trachtman
Publisher: Springer
ISBN: 9783319493787
Category : Medical
Languages : en
Pages : 0

Book Description
This Handbook serves as a convenient, state-of-the-art and comprehensive resource on the pathogenesis, diagnosis, and treatment of glomerular diseases. Clinical approaches, modalities and challenges are provided, along with new developments since the publication of Kidney Disease Improving Global Outcomes (KDIGO): Glomerulonephritis. Chapters dedicated to glomerular diseases mirror the current classification schemes used by Nephrologists and Pathologists and will include definition and natural history, epidemiology, clinical manifestations, pathology, diagnosis, differential diagnosis, treatment (algorithms when appropriate), prognosis and future prospects and current direction of research. Contributing authors consist of internationally renowned glomerulonephritis experts, renal pathologists and clinical nephrologists who are engaged in the management of glomerular diseases in clinical pediatric and internal medicine practices. Glomerulonephritis fills a considerable knowledge gap for general nephrologists, providers involved with the care of patients with glomerular diseases, and researchers. It should also be of value to medical students, interns, residents and fellows, as well as all clinicians engaged in medical education.

Complications of Diabetes Mellitus

Complications of Diabetes Mellitus PDF Author: Jahangir Moini
Publisher: CRC Press
ISBN: 1000554902
Category : Medical
Languages : en
Pages : 241

Book Description
Key Features • Details the latest diagnostic tests and treatments of diabetes and its complications, useful for ready reference by students, physicians, and healthcare professionals. • Explains how heart failure and stroke are deadly complications of diabetes along with kidney failure and life-threatening infections. • Establishes how cancer is linked to diabetes – a fact many people are not aware of – the book details the 6 types of cancer that may result from the disease, along with an individualized focus on the different “areas” of complications that occur from diabetes. • Discusses the effect of diabetes upon the minds of patients, in relation to depression, anxiety, panic, PTSD, eating disorders, delirium, and dementia.

Emerging molecular mechanisms and therapeutics of autoimmune liver or kidney diseases

Emerging molecular mechanisms and therapeutics of autoimmune liver or kidney diseases PDF Author: Jiabo Wang
Publisher: Frontiers Media SA
ISBN: 2832547001
Category : Medical
Languages : en
Pages : 130

Book Description


Silva's Diagnostic Renal Pathology

Silva's Diagnostic Renal Pathology PDF Author: Xin J. Zhou
Publisher: Cambridge University Press
ISBN: 1316613984
Category : Medical
Languages : en
Pages : 691

Book Description
An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.

Molecular Mechanisms of Proteinuria, Volume II

Molecular Mechanisms of Proteinuria, Volume II PDF Author: Ilse Sofia Daehn
Publisher: Frontiers Media SA
ISBN: 2832506054
Category : Medical
Languages : en
Pages : 170

Book Description