Author: Joe V. ChakkalakalPublisher:
ISBN:
Category : Calmodulin
Languages : en
Pages : 790
Book Description
Molecular Mechanisms Affecting Utrophin Expression in Fast Versus Slow Skeletal Muscles ; Possible Therapeutic Targets for Duchenne Muscular Dystrophy
Author: Joe V. ChakkalakalPublisher:
ISBN:
Category : Calmodulin
Languages : en
Pages : 790
Book Description
Molecular Mechanisms Contributing to the Expression of Utrophin at the Mammalian Neuromuscular Synapse
Author: Anthony O. GramoliniPublisher:
ISBN:
Category : Duchenne muscular dystrophy
Languages : en
Pages : 588
Book Description
Investigating the Potential Effectiveness of Two Therapeutic Targets, Utrophin and HSP70, in the Treatment of Duchenne Muscular Dystrophy
Author: Daniel SpensieriMolecular Mechanisms of Muscular Dystrophies
Author: Steve J. WinderPublisher: CRC Press
ISBN: 1498713963
Category : Science
Languages : en
Pages : 250
Book Description
There is no doubt that the study of the muscular dystrophies in recent years has been exciting and rewarding. It has attracted the attention of many investigators of international repute, and this is reflected in the various contributions to this volume. Molecular Mechanisms of Muscular Dystrophies represents a personal collection of chapters cover
Disorders of Voluntary Muscle
Author: George KarpatiPublisher: Cambridge University Press
ISBN: 9780521650625
Category : Medical
Languages : en
Pages : 800
Book Description
Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.
Mechanisms in Duchenne Muscular Dystrophy Pathophysiology and Treatment
Author: Atsushi AsakuraPublisher: Frontiers Media SA
ISBN: 2832533809
Category : Science
Languages : en
Pages : 150
Book Description
Skeletal Muscle Specific IRES Activity of Utrophin A Is Enhanced by Eef1a2
Author: Adèle CoriatiPublisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Understanding the regulatory mechanisms controlling utrophin A expression at the sarcolemma of dystrophic muscles will facilitate the development of therapeutic strategies to ameliorate the pathophysiological features of Duchenne Muscular Dystrophy (DMD). The main goal of this study was to characterize the regulation of utrophin A IRES activity using a transgenic mouse model expressing the utrophin A 5'UTR bicistronic reporter and to identify trans-acting factors that could mediate IRES activity and endogenous expression of utrophin A. We found that utrophin A IRES activity is specifically expressed in skeletal muscles. Moreover, we identified eEF1A2 as a muscle-specific trans-acting factor that can interact with utrophin A and mediate IRES-dependent translation of utrophin A. Finally, we showed that eEF1A2 mediates endogenous utrophin A expression and localization in skeletal muscle. Identifying pharmacological compounds that would specifically target eEF1A2 and increase endogenous levels of utrophin A expression could serve as a drug-based therapy to treat DMD.
Duchenne Muscular Dystrophy
Author: Jeffrey S. ChamberlainPublisher: CRC Press
ISBN: 0849374456
Category : Medical
Languages : en
Pages : 491
Book Description
Duchenne Muscular Dystrophy (DMD) is one of the most prevalent genetic disorders of childhood and currently stands as an incurable condition. This authoritative guide provides a clear overview of the latest current and experimental approaches to the treatment of DMD and examines the clinical, genetic, and pathophysiological aspects of the disease i
Cardioskeletal Myopathies in Children and Young Adults
Author: John Lynn JefferiesPublisher: Academic Press
ISBN: 0128005807
Category : Medical
Languages : en
Pages : 422
Book Description
Cardioskeletal Myopathies in Children and Young Adults focuses on plaques that kill people in their 40's-50's and the way they start to form in young adulthood. The Annals of Family Medicine report that approximately half of young adults have at least one cardiovascular disease risk factor (Mar 2010), and an increase in cardiovascular mortality rates in young adults was substantiated in a study at Northwestern Medicine (Nov 2011). Given the increasing recognition of genetic triggers behind all types of cardiovascular disease, and the growing population of young adults with primary or acquired myocardial disease, the need has arisen for a reference that offers a comprehensive approach to the understanding of basic, translational, and clinical aspects of specific muscle diseases while making the link between young adult and adult health. - Reveals the link between cardiac muscle disease and skeletal muscle disease - Explains how genetics and environmental factors effect muscle function of diverse origins - Designates current and novel therapeutic strategies that target both cardiac and skeletal muscle systems
Muscular Dystrophy
Author: Madhuri HegdePublisher: BoD – Books on Demand
ISBN: 9535106031
Category : Medical
Languages : en
Pages : 558
Book Description
With more than 30 different types and subtypes known and many more yet to be classified and characterized, muscular dystrophy is a highly heterogeneous group of inherited neuromuscular disorders. This book provides a comprehensive overview of the various types of muscular dystrophies, genes associated with each subtype, disease diagnosis, management as well as available treatment options. Though each different type and subtype of muscular dystrophy is associated with a different causative gene, the majority of them have overlapping clinical presentations, making molecular diagnosis inevitable for both disease diagnosis as well as patient management. This book discusses the currently available diagnostic approaches that have revolutionized clinical research. Pathophysiology of the different muscular dystrophies, multifaceted functions of the involved genes as well as efforts towards diagnosis and effective patient management, are also discussed. Adding value to the book are the included reports on ongoing studies that show a promise for future therapeutic strategies.