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Author: Markus J. Tamás Publisher: Springer Science & Business Media ISBN: 3540317198 Category : Science Languages : en Pages : 519
Book Description
One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.
Author: Markus J. Tamás Publisher: Springer Science & Business Media ISBN: 3540317198 Category : Science Languages : en Pages : 519
Book Description
One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.
Author: Stephanie E. Mohr Publisher: Frontiers Media SA ISBN: 2889455564 Category : Languages : en Pages : 144
Book Description
Metals such as copper, iron, manganese, and zinc are clearly required for proper metabolism and development, while imbalances can lead to systemic dysfunction and disease. As a result, organisms have evolved complex genetic systems for the regulation of metal levels, including import, export, and sequestration of metals within cells and sub-cellular compartments. The study of metal biology in insects has the potential to greatly expand our understanding of metal biology. The results of such studies might point to new possible therapeutic interventions for neurological and other human diseases, as well as new strategies for insect disease vector control. The articles collected in this Research Topic comprise review and original research on metal biology in insects.
Author: Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
Metals such as copper, iron, manganese, and zinc are clearly required for proper metabolism and development, while imbalances can lead to systemic dysfunction and disease. As a result, organisms have evolved complex genetic systems for the regulation of metal levels, including import, export, and sequestration of metals within cells and sub-cellular compartments. The study of metal biology in insects has the potential to greatly expand our understanding of metal biology. The results of such studies might point to new possible therapeutic interventions for neurological and other human diseases, as well as new strategies for insect disease vector control. The articles collected in this Research Topic comprise review and original research on metal biology in insects.
Author: Dean H. Hamer Publisher: Wiley-Liss ISBN: 9780471507017 Category : Science Languages : en Pages : 512
Book Description
Discusses how metals are routed and incorporated into regulatory and catalytic proteins and how their pathways are regulated. Describes the diverse strategies that organisms have adopted to acquire, utilize, and store essential metals while protecting themselves against metal toxicity. Metal ion homeostasis and detoxification are considered in terms of structure and regulation. Covers the role of metals in DNA-binding proteins and gene regulation, the chemistry and biology of metal-binding peptides, and methods of metal detoxification. Also includes structural and functional studies of metalloproteins, and a section on the physiology and diseases of unbalanced metal ion homeostasis.
Author: Dietrich H. Nies Publisher: Springer Science & Business Media ISBN: 3540697713 Category : Science Languages : en Pages : 455
Book Description
This book covers allocation of metals in cells, metal transporter, storage and metalloregulatory proteins, cellular responses to metal ion stress, transcription of genes involved in metal ion homeostasis, uptake of essential metals, metal efflux and other detoxification mechanisms. The book also discusses metal bioreporters for the nanomolar range of concentration and tools to address the metallome. In addition, coverage details specific metals.
Author: Irena Sherameti Publisher: Springer Science & Business Media ISBN: 3642214088 Category : Science Languages : en Pages : 468
Book Description
Heavy metals are severe environmental pollutants, and many of them are toxic even at very low concentrations. With industrial development, soil pollution with heavy metal elements have dramatically increased. The uptake of heavy metals via plants that are exposed to contaminated soils is a risk for human health and a major hazard for the ecosystem as a whole, including soil microorganisms. On the other hand, plants may be used in the decontamination of soils. The topics presented in this book include: sources of heavy metals contaminants in soils; plant species that can grow on contaminated soils; the phytoremediation of contaminated soils; tolerance, accumulation and detoxification mechanisms of zinc, copper, arsenic, cadmium and vanadium in plants; the critical role of sulfur metabolism in heavy metal tolerance; the role of aquatic macrophytes, plant growth-promoting bacteria, sugar crops and earthworms in detoxification; and heavy metal stabilization by promoting zeolite synthesis in soils.
Author: Rudolfs K. Zalups Publisher: CRC Press ISBN: 142005998X Category : Medical Languages : en Pages : 442
Book Description
With chapter contributions from more than 30 metal biology experts, Cellular and Molecular Biology of Metals explains the role of key divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals, such as nickel, zinc, and chromium, the text also discusses
Author: Rüdiger Hell Publisher: Springer Science & Business Media ISBN: 3642106137 Category : Science Languages : en Pages : 312
Book Description
Plants are composed of 17 essential and at least 5 beneficial elements, and these must be taken up as metal or nutrient ions to allow for growth and cell division. Much effort has been devoted to studying the physiology and biochemistry of metals and nutrients in plants. The aspect of cell biology, however, is an emerging new field and much needs to be learned about sensing, long-distance communication within plants, and cellular signal transduction chains in response to environmental stress. Cellular malfunction and consequently disease result when any of the key steps in metal and nutrient homeostasis are disrupted. Working together, leading experts in their respective fields provide a new concept that reaches beyond plant nutrition and plasmalemma transport into cellular physiology. Each chapter contains basic information on uptake, physiological function, deficiency and toxicity syndromes, long-distance and intracellular transport. The discussion is devoted to metals and nutrients where recent progress has been made and highlights the aspects of homeostasis and sensing, signaling and regulation, drawing parallels to other organisms including humans. Finally, the book identifies gaps in our current knowledge and lays out future research directions.
Author: Marc Joseph Frayna Gallenito Publisher: ISBN: Category : Adenosine triphosphatase Languages : en Pages : 0
Book Description
Because of their unique chemistry, transition metals are central to the function of one-third of all proteins identified in the human proteome, thus, play pivotal roles in biological processes. Yet, abnormal metal distribution underlies cellular toxicity. Every cell, as well as whole organisms, is therefore challenged to tightly control and maintain appropriate concentrations of metals while excluding nonessential, toxic metals. Cellular metal import and export often require transmembrane transporter proteins embedded in the membrane. In this dissertation, we investigate the chemical roles underlying selectivity and translocation mechanism of transmembrane proteins involved in metal transport with the aim of shedding light on how homeostasis, detoxification and metal-based drug resistance is achieved. Atomic resolution understanding of metal selectivity by membrane proteins has remained largely elusive. The P1B-type ATPase pumps represent transporters with wide and overlapping substrate specificities. A Zn2+-transporting P-type ATPase (ZntA) was utilized as a model system to understand how metal promiscuity against Zn2+, Cd2+, Hg2+, and Pb2+ is obtained at a molecular level. We dissected the coordination chemistry of metal-bound forms of ZntA through biochemical tools and X-ray absorption spectroscopy analysis. We revealed that coordination plasticity is required to guarantee substrate promiscuity of ZntA. Moreover, our results indicated that divergence from ideal ligand sets and geometries is required for efficient metal translocation by ZntA during its catalytic cycle. The pathology and entrance into the cells of therapeutic metals must also be based on similar coordination chemistry principles of trafficking that govern physiological trace metals. Platinumcoordination complexes are among the most effective chemotherapeutic drugs used in clinic for the treatment of cancer. Despite their efficacy, cancer cells can develop drug resistance leading to treatment failure and relapse. Cellular uptake and extrusion of Pt(II)-complexes mediated by transmembrane proteins are critical in controlling the intracellular concentrations of Pt(II)-drugs and in developing pre-target resistance. TMEM205 is a human transmembrane protein (hTMEM205) overexpressed in cancer cells resistant to cisplatin, but its molecular function underlying resistance remains elusive. We developed a low-cost and high-throughput recombinant expression platform coupled to in vivo functional resistance assays to address the molecular mechanism by which the orphan hTMEM205 protects against Pt(II)-complex toxicity. We demonstrate that hTMEM205 mediates Pt(II)-drug export selectively towards cisplatin and oxaliplatin but not carboplatin. Thus, hTMEM205 represents a new potential target that can be exploited to reduce cellular resistance towards Pt(II)-drugs. We subsequently investigated the nature of the physiological role of the “orphan” hTMEM205 and addressed whether it could exert its function as a novel Cu(I) transporter. The rationale behind this hypothesis is two-pronged: 1) Cu homeostatic pathways have been proposed to act as cisplatin transport systems and 2) Cu(I) and Pt(II) interact with similar biological ligands due to their comparable chemical coordination chemistry preferences according to the Pearson acid-base theory. In this work, through a combination of in vivo and in vitro activity assays, we defined that hTMEM205 is a novel human Cu(I) transporter. First, we developed a bacterial-based approach to show the directionality of hTMEM205-mediated copper transport. Second, successful purification of recombinant hTMEM205 allowed the establishment of a hTMEM205-reconstituted proteoliposome platform to dissect its enzymatic transport activity. By mutagenesis, we revealed that hTMEM205 recognize and mediate Cu(I) extrusion by a putative sulfur-based translocation mechanism. This work sheds light on the physiological relevance of hTMEM205 in cellular metal metabolism and establishes a new transporter-based copper pathway.
Author: Jose M. Arguello Publisher: Academic Press ISBN: 0123943906 Category : Science Languages : en Pages : 478
Book Description
This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise
Author: Markus J. Tamás
Author: Markus J. Tamás
Author: Stephanie E. Mohr
Author: 
Author: Dean H. Hamer
Author: Dietrich H. Nies
Author: Irena Sherameti
Author: Rudolfs K. Zalups
Author: Rüdiger Hell
Author: Marc Joseph Frayna Gallenito
Author: Jose M. Arguello