Author: Donald Lee BehrmannPublisher:
ISBN:
Category :
Languages : en
Pages : 268
Book Description
Modelling of Spinal Cord Injury in the Rat
Author: Donald Lee BehrmannThe Rat as a Model for Spinal Cord Injury
Author: Halina Ruth FliegelPublisher:
ISBN:
Category : Spinal cord
Languages : en
Pages : 104
Book Description
Modeling Incomplete Cervical Spinal Cord Injury in Rats to Explore Mechanisms of Rehabilitative Training
Author: Caitlin L. HurdPublisher:
ISBN:
Category : Spinal cord
Languages : en
Pages : 110
Book Description
Although limited functional recovery is observed following spinal cord injury (SCI), the most successful approach to promote recovery to date has been rehabilitative training. However, the effects of training are not stunning. With a thorough understanding of the intracellular mechanisms involved in training- induced recovery as well as a re-evaluation of the animal models used, it may be possible to enhance training efficacy following SCI. This thesis describes a study in which the cyclic AMP/protein kinase A intracellular signaling pathway was inhibited throughout rehabilitative reaching training in a rat model of incomplete cervical SCI to characterize its role in training-induced recovery. Additionally, a re-evaluation of a single pellet skilled reaching test is described in which an animal model of rehabilitative training and reaching recovery is analyzed. These data contribute to our understanding of rehabilitative training in animal models of SCI and may lead to greater improvements in this treatment approach.
A Study of Rat Spinal Cord Injury Using Three Different Models
Author: Leanna Beatrice LoyModeling and Treatment of Rat Cervical Spinal Cord Injury
Author: John Carib GenselPublisher:
ISBN:
Category : Bruises
Languages : en
Pages : 200
Book Description
Abstract: Spinal cord injury (SCI) is a long lasting, debilitating condition with no cure. Cervical SCI is the most common form of human SCI, often leaving patients paralyzed with a 15-20 year decrease in life expectancy. The majority of animal SCI contusion models are focused on thoracic injury. SCI at this level results in deficits almost entirely due to white matter damage that disconnects the rostral nervous system from the caudal spinal cord. Damage at the cervical level is different; in addition to the disconnection, gray matter damage affects the neurons controlling the upper extremities and diaphragm. To investigate injury at the cervical level, we characterized a unilateral C5 cervical contusion model in rats. By examining six-week behavioral recovery after SCI, we demonstrated that functional deficits are dependent upon the severity of injury. Analysis of the histopathology revealed that behavioral consequences are a result of damage to both the gray and white matter. Unilateral injury provides within-subject controls and preserves bladder and respiratory function. Many treatments for experimental rat SCI improve behavioral and histological outcomes but have yet to be implemented after human SCI. Treatments must be safe and tested in clinically relevant models to move from animals to humans. We examined the effects of three different clinically acceptable drugs. Methlyprednisolone and minocycline have anti-inflammatory effects if given after injury. Topiramate blocks glutamate receptors and hence excitotoxicity, an important component of secondary injury. Minocycline and methylprednisolone treatment yielded no significant behavioral or histological improvements when tested after moderate-severe unilateral cervical contusion injury. Topiramate was first tested in a model of excitotoxicity and then after cervical SCI and was compared to NBQX, a standard AMPA-receptor antagonists used in animal models of disease. Both drugs preserved neurons after excitotoxic injury, but only topiramate was found to protect neurons after SCI. More small and medium sized neurons were spared in the topiramate treated group compared to control 48 hours after SCI. NBQX treatment increased white matter sparing compared to control, but resulted in worse motor function compared to topiramate. Both treatments were only effective when applied after moderate-severe injury and not after mild injury.
Assessment of Spinal Cord Injury in a Rat Model Using an Orthogonal Filter-probe Diffusion Encoding Scheme
Author: Nathan Phillip SkinnerPublisher:
ISBN: 9780438707498
Category :
Languages : en
Pages : 136
Book Description
A Study of Rat Spinal Cord Injury Using Three Different Models [microform]
![A Study of Rat Spinal Cord Injury Using Three Different Models [microform] PDF](https://books.google.com/books/content/images/frontcover/-PggNAEACAAJ?fife=w80-h100)
Author: Leanna Beatrice LoyPublisher: Montréal : Service des archives, Université de Montréal, Section Microfilm
ISBN:
Category :
Languages : en
Pages : 218
Book Description
Author: 
Author: Natasha J. Olby
Author: