Modeling and simulation of biological networks : American Mathematical Society short course, January 10 - 11, 2006, San Antonio, Texas ; [lecture notes prepared for the American Mathematical Society Short Course Modeling and Simulation of Biological Networks, held in San Antonio, Texas, January 10 - 11, 2006] PDF Download

Author: Reinhard C. Laubenbacher
Publisher:
ISBN: 9780821839645
Category :
Languages : en
Pages : 0

View

Book Description

Author: American Mathematical Society. Short Course, Modeling and Simulation of Biological Networks
Publisher: American Mathematical Soc.
ISBN: 0821839640
Category : Mathematics
Languages : en
Pages : 161

View

Book Description
The aim of this volume is to explain some of the biology and the computational and mathematical challenges with the modeling and simulation of biological networks. The different chapters provide examples of how these challenges are met, with particular emphasis on nontraditional mathematical approaches. The volume features a broad spectrum of networks across scales, ranging from biochemical networks within a single cell to epidemiological networks encompassing whole cities. Also, this volume is broad in the range of mathematical tools used in solving problems involving these networks.

Author: American Mathematical Society. Short Course, Modeling and Simulation of Biological Networks
Publisher: American Mathematical Society(RI)
ISBN: 9780821892794
Category : NATURE
Languages : en
Pages : 160

View

Book Description
It is the task of computational biology to help elucidate the unique characteristics of biological systems. This process has barely begun, and many researchers are testing computational tools that have been used successfully in other fields. Mathematical and statistical network modeling is an important step toward uncovering the organizational principles and dynamic behavior of biological networks. Undoubtedly, new mathematical tools will be needed, however, to meet this challenge. The workhorse of this effort at present comprises the standard tools from applied mathematics, which have proven to be successful for many problems. But new areas of mathematics not traditionally considered applicable are contributing other powerful tools. This volume is intended to introduce this topic to a broad mathematical audience. The aim is to explain some of the biology and the computational and mathematical challenges we are facing. The different chapters provide examples of how these challenges are met, with particular emphasis on nontraditional mathematical approaches.The volume features a broad spectrum of networks across scales, ranging from biochemical networks within a single cell to epidemiological networks encompassing whole cities. Chapter topics include phylogenetics and gene finding using tools from statistics and algebraic geometry, biochemical network inference using tools from computational algebra, control-theoretic approaches to drug delivery using differential equations, and interaction-based modeling and discrete mathematics applied to problems in population dynamics and epidemiology.

Author: American Mathematical Society. Short course
Publisher: American Mathematical Soc.
ISBN: 0821867717
Category : Mathematics
Languages : en
Pages : 203

View

Book Description
The first three chapters of this book introduce the reader to knot theory, topological chirality and molecular symmetry, and DNA topology. The second half of the book is focused on three particular applications of knot theory.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309042283
Category : Mathematics
Languages : en
Pages : 148

View

Book Description
As requested by the National Science Foundation (NSF) and the Interagency Committee for Extramural Mathematics Programs (ICEMAP), this report updates the 1984 Report known as the "David Report." Specifically, the charge directed the committee to (1) update that report, describing the infrastructure and support for U.S. mathematical sciences research; (2) assess trends and progress over the intervening five years against the recommendations of the 1984 Report; (3) briefly assess the field scientifically and identify significant opportunities for research, including cross-disciplinary collaboration; and (4) make appropriate recommendations designed to ensure that U.S. mathematical sciences research will meet national needs in coming years. Of the several components of the mathematical sciences community requiring action, its wellspring--university research departments--is the primary focus of this report. The progress and promise of research--described in the 1984 Report relative to theoretical development, new applications, and the refining and deepening of old applications--have if anything increased since 1984, making mathematics research ever more valuable to other sciences and technology. Although some progress has been made since 1984 in the support for mathematical sciences research, the goals set in the 1984 Report have not been achieved. Practically all of the increase in funding has gone into building the infractructure, which had deteriorated badly by 1984. While graduate and postdoctoral research, computer facilities, and new institutes have benefited from increased resources, some of these areas are still undersupported by the standards of other sciences. And in the area of research support for individual investigators, almost no progress has been made. A critical storage of qualified mathematical sciences researchers still looms, held at bay for the moment by a large influx of foreign researchers, an uncertain solution in the longer term. While government has responded substantially to the 1984 Report's recommendations, particularly in the support of infrastructure, the universities generally have not, so that the academic foundations of the mathematical sciences research enterprise are as shaky now as in 1984. The greatet progress has been made in the mathematics sciences community, whose members have shown a growing awareness of the problems confronting their discipline and increased interest in dealing with the problems, particularly in regard to communication with the public and government agencies and involvement in education. (AA)

Author: Peter Deuflhard
Publisher: Springer
ISBN: 3319200593
Category : Mathematics
Languages : en
Pages : 185

View

Book Description
This book is intended for students of computational systems biology with only a limited background in mathematics. Typical books on systems biology merely mention algorithmic approaches, but without offering a deeper understanding. On the other hand, mathematical books are typically unreadable for computational biologists. The authors of the present book have worked hard to fill this gap. The result is not a book on systems biology, but on computational methods in systems biology. This book originated from courses taught by the authors at Freie Universität Berlin. The guiding idea of the courses was to convey those mathematical insights that are indispensable for systems biology, teaching the necessary mathematical prerequisites by means of many illustrative examples and without any theorems. The three chapters cover the mathematical modelling of biochemical and physiological processes, numerical simulation of the dynamics of biological networks and identification of model parameters by means of comparisons with real data. Throughout the text, the strengths and weaknesses of numerical algorithms with respect to various systems biological issues are discussed. Web addresses for downloading the corresponding software are also included.

Author: James Sneyd
Publisher: American Mathematical Soc.
ISBN: 9780821867648
Category : Medical
Languages : en
Pages : 196

View

Book Description
In many respects, biology is the new frontier for applied mathematicians. This book demonstrates the important role mathematics plays in the study of some biological problems. It introduces mathematicians to the biological sciences and provides enough mathematics for bioscientists to appreciate the utility of the modelling approach. The book presents a number of diverse topics, such as neurophysiology, cell biology, immunology, and human genetics. It examines how research is done,what mathematics is used, what the outstanding questions are, and how to enter the field. Also given is a brief historical survey of each topic, putting current research into perspective. The book is suitable for mathematicians and biologists interested in mathematical methods in biology.

Author: Andreas Deutsch
Publisher: Springer Science & Business Media
ISBN:
Category : Mathematics
Languages : en
Pages : 408

View

Book Description
This edited volume contains a selection of chapters that are an outgrowth of the - ropean Conference on Mathematical and Theoretical Biology (ECMTB05, Dresden, Germany, July 2005). The peer-reviewed contributions show that mathematical and computational approaches are absolutely essential for solving central problems in the life sciences, ranging from the organizational level of individual cells to the dynamics of whole populations. The contributions indicate that theoretical and mathematical biology is a diverse and interdisciplinary ?eld, ranging from experimental research linked to mathema- cal modeling to the development of more abstract mathematical frameworks in which observations about the real world can be interpreted, and with which new hypotheses for testing can be generated. Today, much attention is also paid to the development of ef?cient algorithms for complex computation and visualisation, notably in molecular biology and genetics. The ?eld of theoretical and mathematical biology and medicine has profound connections to many current problems of great relevance to society. The medical, industrial, and social interests in its development are in fact indisputable.

Author: Joseph Henrich
Publisher: Farrar, Straus and Giroux
ISBN: 0374710457
Category : Psychology
Languages : en
Pages : 420

View

Book Description
A New York Times Notable Book of 2020 A Bloomberg Best Non-Fiction Book of 2020 A Behavioral Scientist Notable Book of 2020 A Human Behavior & Evolution Society Must-Read Popular Evolution Book of 2020 A bold, epic account of how the co-evolution of psychology and culture created the peculiar Western mind that has profoundly shaped the modern world. Perhaps you are WEIRD: raised in a society that is Western, Educated, Industrialized, Rich, and Democratic. If so, you’re rather psychologically peculiar. Unlike much of the world today, and most people who have ever lived, WEIRD people are highly individualistic, self-obsessed, control-oriented, nonconformist, and analytical. They focus on themselves—their attributes, accomplishments, and aspirations—over their relationships and social roles. How did WEIRD populations become so psychologically distinct? What role did these psychological differences play in the industrial revolution and the global expansion of Europe during the last few centuries? In The WEIRDest People in the World, Joseph Henrich draws on cutting-edge research in anthropology, psychology, economics, and evolutionary biology to explore these questions and more. He illuminates the origins and evolution of family structures, marriage, and religion, and the profound impact these cultural transformations had on human psychology. Mapping these shifts through ancient history and late antiquity, Henrich reveals that the most fundamental institutions of kinship and marriage changed dramatically under pressure from the Roman Catholic Church. It was these changes that gave rise to the WEIRD psychology that would coevolve with impersonal markets, occupational specialization, and free competition—laying the foundation for the modern world. Provocative and engaging in both its broad scope and its surprising details, The WEIRDest People in the World explores how culture, institutions, and psychology shape one another, and explains what this means for both our most personal sense of who we are as individuals and also the large-scale social, political, and economic forces that drive human history. Includes black-and-white illustrations.

Author: James Sneyd
Publisher:
ISBN: 9780821892749
Category : MEDICAL
Languages : en
Pages : 194

View

Book Description
In many respects, biology is the new frontier for applied mathematicians. This book demonstrates the important role mathematics plays in the study of some biological problems. It introduces mathematicians to the biological sciences and provides enough mathematics for bioscientists to appreciate the utility of the modelling approach. The book presents a number of diverse topics, such as neurophysiology, cell biology, immunology, and human genetics. It examines how research is done, what mathematics is used, what the outstanding questions are, and how to enter the field. Also given is a brief historical survey of each topic, putting current research into perspective. The book is suitable for mathematicians and biologists interested in mathematical methods in biology.