Mitochondrial Gene Expression PDF Download

Author:
Publisher:
ISBN: 9781071608340
Category : Gene expression
Languages : en
Pages :

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Author: Michal Minczuk
Publisher: Humana
ISBN: 9781071608333
Category : Medical
Languages : en
Pages : 334

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Book Description
This volume details the most recent advancements in the field of mitochondrial gene expression. Chapters guide readers through methods and protocols on mtDNA replication, transcription, and translation to membrane insertion of the mtDNA-encoded protein products. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mitochondrial Gene Expression: Methods and Protocols aims to provide complementary approaches and practical guidelines. Chapter 7 is available Open Access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author: Michal Minczuk
Publisher: Humana
ISBN: 9781071608364
Category : Medical
Languages : en
Pages : 333

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Book Description
This volume details the most recent advancements in the field of mitochondrial gene expression. Chapters guide readers through methods and protocols on mtDNA replication, transcription, and translation to membrane insertion of the mtDNA-encoded protein products. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mitochondrial Gene Expression: Methods and Protocols aims to provide complementary approaches and practical guidelines. Chapter 7 is available Open Access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author: Giuseppe Attardi
Publisher: Gulf Professional Publishing
ISBN: 9780121821654
Category : Aging
Languages : en
Pages : 658

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The critically acclaimed laboratory standard for forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerlyawaited, frequently consulted, and praised by researchers and reviewers alike. More than 250 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features * Structural and functional analysis of oxidative phosphorylation complexes * Import of proteins and RNA into mitochondria * Ion and metabolite transport systems in mitochondria * Biophysical methods for mitochondrial function analysis * Mitochondrial inheritance and turnover.

Author: Maria Isabel Guadalupe Lopez Sanchez
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Human mitochondrial DNA is a distinct, compact genetic system that encodes proteins crucial for energy metabolism in the cell. Due to its reduced size and relatively simple organisation, all the regulatory factors directing the expression of the mitochondrial genome are encoded by nuclear DNA. It is evident that mitochondrial gene expression is regulated at different levels, which is reflected by the numerous diseases associated with mutations in both nuclear and mitochondrial DNA-encoded mitochondrial proteins. Research focusing on the identification and characterisation of RNA-binding proteins as regulators of mitochondrial function is ongoing. However, the components and mechanisms involved in the post-transcriptional regulation of mitochondrial DNA are not well understood. The aim of this research project was to investigate different aspects of the regulation of human mitochondrial gene expression via the direct action of nuclear-encoded mitochondrial proteins on RNA metabolism. First, I validated the proteins responsible for 5' end processing of mitochondrial precursor transcripts and identified the protein responsible for 3' end processing cleavage, showing that they are important for mitochondrial function. Next, I studied a previously uncharacterised mitochondrial ribosomal subunit protein and found that it is an important factor in the regulation of protein synthesis. Finally, I examined a protein that has multiple and independent functions in the organelle and identified it as a new target for the estrogenic modulation of mitochondrial gene expression via the estrogen receptor alpha. Both the nuclear and the mitochondrial genomes contribute to the mitochondrial proteome and hence to mitochondrial function. Because mitochondria possess a genome that is central to multiple cellular functions, understanding the different levels and mechanisms involved in the regulation of mitochondrial gene expression is essential in elucidating the contribution of mitochondrial dysfunction to human disease.

Author: Terrie Lorraine Ulery
Publisher:
ISBN:
Category :
Languages : en
Pages : 400

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Author:
Publisher: Academic Press
ISBN: 0123944422
Category : Science
Languages : en
Pages : 485

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Book Description
Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume features reviews on Mitochondrial genome evolution. Publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology This thematic volume features reviews on mitochondrial genome evolution

Author: Giuseppe Gasparre
Publisher: Academic Press
ISBN: 0128226420
Category : Science
Languages : en
Pages : 596

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The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

Author: Craig E. Cameron
Publisher:
ISBN:
Category :
Languages : en
Pages : 197

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Author:
Publisher:
ISBN:
Category : Active oxygen
Languages : en
Pages :

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