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Author: Sergey Korotkov Publisher: Academic Press ISBN: 0323955320 Category : Science Languages : en Pages : 280
Book Description
Mitochondria as a Key Intracellular Target of Thallium Toxicity presents a new hypothesis that explains the decrease in antioxidant defense of thallium poisoning and proposes a new model for studying the transport of inorganic cations across the inner mitochondrial membrane. Readers will learn about the toxicity of thallium and its compounds, the toxicology of thallium, the toxic thallium effects on cells, and the effects of thallium on mitochondria. In addition, the book lists the pathways and mechanisms of thallium transport into cells and mitochondria, including information on toxicity that has been analyzed at both the cellular and subcellular levels. The increase in human contact with the toxic trace element thallium is associated with industry development, the release of metal into the environment from various rocks, and the use of special isotope techniques for studying the vascular bed. Highlights the differences between the toxic effect of thallium and the action of other heavy metals on cells and mitochondria Explains why the toxicity of thallium in experiments in vivo is higher than that of bivalent heavy metals Discusses the applied in vitro model when searching for new inhibitors of the mitochondrial permeability transition pore
Author: Sergey Korotkov Publisher: Academic Press ISBN: 0323955320 Category : Science Languages : en Pages : 280
Book Description
Mitochondria as a Key Intracellular Target of Thallium Toxicity presents a new hypothesis that explains the decrease in antioxidant defense of thallium poisoning and proposes a new model for studying the transport of inorganic cations across the inner mitochondrial membrane. Readers will learn about the toxicity of thallium and its compounds, the toxicology of thallium, the toxic thallium effects on cells, and the effects of thallium on mitochondria. In addition, the book lists the pathways and mechanisms of thallium transport into cells and mitochondria, including information on toxicity that has been analyzed at both the cellular and subcellular levels. The increase in human contact with the toxic trace element thallium is associated with industry development, the release of metal into the environment from various rocks, and the use of special isotope techniques for studying the vascular bed. Highlights the differences between the toxic effect of thallium and the action of other heavy metals on cells and mitochondria Explains why the toxicity of thallium in experiments in vivo is higher than that of bivalent heavy metals Discusses the applied in vitro model when searching for new inhibitors of the mitochondrial permeability transition pore
Author: Ozgur Karcioglu Publisher: BoD – Books on Demand ISBN: 1838807853 Category : Medical Languages : en Pages : 130
Book Description
Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: "All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy." This is often condensed to: "The dose makes the poison." So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.
Author: Jan Aaseth Publisher: Academic Press ISBN: 0128030739 Category : Medical Languages : en Pages : 388
Book Description
Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds
Author: Publisher: ISBN: Category : Government publications Languages : en Pages : 728
Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: P.L. Chambers Publisher: Springer Science & Business Media ISBN: 3642690831 Category : Medical Languages : en Pages : 407
Book Description
Many chemotherapeutic agents introduced for use in humans are carcinogenic in laboratory animals (Conklin et al. 1965; Shimkin et al. 1966; Griswold et al. 1968; Harris 1976). However, initially their beneficial effect in disseminated cancer was of such short duration that the inevitable death of the patient from his primary disease precluded any clinical manifestation of the carcinogenic potential. During the last decade, chemotherapy has radically changed the outlook for many patients with cancer. Combinations of drugs, administered as the primary treatment, have resulted in high rates of cure in patients with disseminated malignancies, such as stage IV Hodgkin's disease or childhood acute lymphocytic leukemia. In other disseminated forms of neoplasia, induction of a remission, a substantial palliation and a prolongation of survival have been achieved. In many instances of localised disease, where surgery with or without radiotherapy are the primary form of treatment, anticancer drugs have been used with success as adjuvant therapy for distant microscopic disease. With these spectacular achievements, secondary malignancies, in particular acute non-lymphocytic leukemia (ANLL), has become of major concern. Incidence Acute leukemia is the most frequent form of secondary neoplasia in patients treated for cancer (Penn 1981). In one large series, 5. 9% of all ANLL could be attributed to previous chemotherapy (Kapadia et al. 1980).
Author: Ramesh C. Gupta Publisher: Academic Press ISBN: 0128146567 Category : Medical Languages : en Pages : 1246
Book Description
Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more
Author: Jean-Pierre Vernet Publisher: Elsevier Publishing Company ISBN: Category : Nature Languages : en Pages : 480
Book Description
Highlighted in this compilation of papers is the role and importance of heavy metals in the environment. It provides up-to-date information in a field of active research and progress, where the focus is on effects and interactions between the environment and organisms, as well as contaminant dynamics. Several papers address the impact of heavy metals on our health. The influence of metals on plants is described in an exhaustive study on lichens, which have been widely used as biomonitors for environmental contamination by heavy metals. Metals are also accumulated by animals, as seen in a chapter which focusses on sediment/benthic organism interactions and biomonitoring in fish. Soil interactions are discussed, as well as regional studies of freshwater sediments and the marine environment. The final part of the book addresses a crucial problem: the management of stabilized municipal waste sludges. As a result, the most important and significant recent trends are included, emphasizing interactions with and impacts of heavy metals on humans, animals, plants and soils.
Author: Claude Amiard-Triquet Publisher: Academic Press ISBN: 0128011769 Category : Science Languages : en Pages : 519
Book Description
Aquatic Ecotoxicology: Advancing Tools for Dealing with Emerging Risks presents a thorough look at recent advances in aquatic ecotoxicology and their application in assessing the risk of well-known and emerging environmental contaminants. This essential reference, brought together by leading experts in the field, guides users through existing and novel approaches to environmental risk assessment, then presenting recent advances in the field of ecotoxicology, including omics-based technologies, biomarkers, and reference species. The book then demonstrates how these advances can be used to design and perform assays to discover the toxicological endpoints of emerging risks within the aquatic environment, such as nanomaterials, personal care products, PFOS and chemical mixtures. The text is an invaluable reference for any scientist who studies the effects of contaminants on organisms that live within aquatic environments. Provides the latest perspectives on emerging toxic risks to aquatic environments, such as nanomaterials, pharmaceuticals, chemical mixtures, and perfluorooctane sulfonate (PFOS) Offers practical guidance on recent advances to help in choosing the most appropriate toxicological assay Presents case studies and information on a variety of reference species to help put the ecotoxicological theory into practical risk assess
Author: Sergey Korotkov
Author: Sergey Korotkov
Author: Louis J. Casarett
Author: Ozgur Karcioglu
Author: Jan Aaseth
Author: 
Author: P.L. Chambers
Author: Ramesh C. Gupta
Author: Jean-Pierre Vernet
Author: Claude Amiard-Triquet
Author: Peter Walde